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    IGF2BP2 insulin like growth factor 2 mRNA binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 10644, updated on 3-Dec-2024

    Summary

    Official Symbol
    IGF2BP2provided by HGNC
    Official Full Name
    insulin like growth factor 2 mRNA binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:28867
    See related
    Ensembl:ENSG00000073792 MIM:608289; AllianceGenome:HGNC:28867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IMP2; IMP-2; VICKZ2
    Summary
    This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
    Expression
    Broad expression in placenta (RPKM 4.8), colon (RPKM 4.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IGF2BP2 in Genome Data Viewer
    Location:
    3q27.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (185643130..185825042, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (188458961..188640755, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (185360918..185542830, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20926 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185272617-185273292 Neighboring gene lipase H Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:185280735-185281348 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185281349-185281962 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185300277-185301176 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185302322-185302941 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185302942-185303560 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185303561-185304179 Neighboring gene SUMO specific peptidase 2 Neighboring gene ribosomal protein L34 pseudogene 10 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185359885-185360103 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185363553-185364440 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185369908-185370106 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:185406257-185407456 Neighboring gene IGF2BP2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185442702-185443202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185445539-185446390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185446391-185447242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185449611-185450110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14976 Neighboring gene uncharacterized LOC124906313 Neighboring gene Sharpr-MPRA regulatory region 9603 Neighboring gene Sharpr-MPRA regulatory region 5696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185487094-185487594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185487595-185488095 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185491440-185492292 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:185496875-185497772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185497860-185498360 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185501879-185502772 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185504559-185505450 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185507237-185508130 Neighboring gene microRNA 548aq Neighboring gene VISTA enhancer hs1976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185516757-185517258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185517259-185517758 Neighboring gene NANOG hESC enhancer GRCh37_chr3:185520396-185520897 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:185525354-185525896 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:185540833-185541696 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185542636-185542866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14978 Neighboring gene Sharpr-MPRA regulatory region 6530 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:185623478-185623669 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185655136-185655863 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185666824-185667766 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:185667767-185668709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:185670624-185671147 Neighboring gene transformer 2 beta homolog Neighboring gene Sharpr-MPRA regulatory region 2251 Neighboring gene NmrA like redox sensor 2, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Type 2 diabetes mellitus
    MedGen: C0011860 OMIM: 125853 GeneReviews: WFS1 Spectrum Disorder
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    EBI GWAS Catalog
    A genome-wide association study of gestational diabetes mellitus in Korean women.
    EBI GWAS Catalog
    A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
    EBI GWAS Catalog
    Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
    EBI GWAS Catalog
    Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
    EBI GWAS Catalog
    Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
    EBI GWAS Catalog
    Genome-wide association study identifies three novel loci for type 2 diabetes.
    EBI GWAS Catalog
    Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
    EBI GWAS Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
    EBI GWAS Catalog
    SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations.
    EBI GWAS Catalog
    Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
    EBI GWAS Catalog
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    Rev rev Ectopic expression of IMP1 inhibits replication of HIV-1 in SupT1 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686I17155

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N6-methyladenosine-containing RNA reader activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in CRD-mediated mRNA stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in CRD-mediated mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytokine production IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    insulin-like growth factor 2 mRNA-binding protein 2
    Names
    IGF-II mRNA-binding protein 2
    IGF2 mRNA-binding protein 2
    VICKZ family member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011602.1 RefSeqGene

      Range
      4998..186910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007225.3NP_001007226.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform b

      See identical proteins and their annotated locations for NP_001007226.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as p62) is shorter than isoform a.
      Source sequence(s)
      AC016961, AC108670
      Consensus CDS
      CCDS33903.1
      UniProtKB/Swiss-Prot
      Q9Y6M1
      Related
      ENSP00000320204.5, ENST00000346192.7
      Conserved Domains (6) summary
      cd12626
      Location:278
      RRM1_IGF2BP2; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cd12629
      Location:82157
      RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cd22491
      Location:195268
      KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22497
      Location:383459
      KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22500
      Location:466543
      KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cl00098
      Location:276352
      KH-I; K homology (KH) RNA-binding domain, type I
    2. NM_001291869.3NP_001278798.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC016961, AC108670
      Consensus CDS
      CCDS77870.1
      UniProtKB/TrEMBL
      F8W930
      Related
      ENSP00000410242.2, ENST00000457616.6
      Conserved Domains (4) summary
      cd00105
      Location:283348
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:436499
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cd12626
      Location:278
      RRM1_IGF2BP2; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cl17169
      Location:82163
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_001291872.3NP_001278801.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform d

      See identical proteins and their annotated locations for NP_001278801.1

      Status: REVIEWED

      Source sequence(s)
      AC016961, AC108670, AI348863, BC021290, BX106919, EU408701
      UniProtKB/Swiss-Prot
      Q9Y6M1
      Conserved Domains (5) summary
      cd12629
      Location:19100
      RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cd22491
      Location:138211
      KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22494
      Location:219295
      KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22497
      Location:369445
      KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22500
      Location:452529
      KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    4. NM_001291873.3NP_001278802.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform e

      See identical proteins and their annotated locations for NP_001278802.1

      Status: REVIEWED

      Source sequence(s)
      AC016961, AC108670, AI348863, BC021290, BX106919, EU408702
      Consensus CDS
      CCDS77869.1
      UniProtKB/Swiss-Prot
      Q9Y6M1
      Related
      ENSP00000413787.3, ENST00000421047.3
      Conserved Domains (5) summary
      cd12629
      Location:1994
      RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cd22491
      Location:132205
      KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22494
      Location:213289
      KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22497
      Location:363439
      KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22500
      Location:446523
      KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
    5. NM_001291874.3NP_001278803.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform f

      See identical proteins and their annotated locations for NP_001278803.1

      Status: REVIEWED

      Source sequence(s)
      AC016961, AC108670, AI348863, AK296703, BC021290, BX106919, EU408703
      UniProtKB/Swiss-Prot
      Q9Y6M1
      UniProtKB/TrEMBL
      B4DKT5
      Conserved Domains (4) summary
      cd12629
      Location:1994
      RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cd22497
      Location:320396
      KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22500
      Location:403480
      KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cl00098
      Location:213289
      KH-I; K homology (KH) RNA-binding domain, type I
    6. NM_001291875.3NP_001278804.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC016961, AC108670, AI348863, BC021290, BX106919, EU408704
      UniProtKB/Swiss-Prot
      Q9Y6M1
      UniProtKB/TrEMBL
      B3FTN5
      Conserved Domains (3) summary
      cd00105
      Location:141206
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:294357
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cl17169
      Location:121
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. NM_006548.6NP_006539.3  insulin-like growth factor 2 mRNA-binding protein 2 isoform a

      See identical proteins and their annotated locations for NP_006539.3

      Status: REVIEWED

      Source sequence(s)
      AC016961, AI348863, AK290664, BC021290, BX106919, BY795845
      Consensus CDS
      CCDS3273.2
      UniProtKB/Swiss-Prot
      A0A4Z0, B3FTN2, B3FTN3, B3FTN4, Q9Y6M1
      Related
      ENSP00000371634.3, ENST00000382199.7
      Conserved Domains (6) summary
      cd12626
      Location:278
      RRM1_IGF2BP2; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cd12629
      Location:82157
      RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cd22491
      Location:195268
      KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22494
      Location:276352
      KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22497
      Location:426502
      KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22500
      Location:509586
      KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

    RNA

    1. NR_138486.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate segment in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC016961, AC108670

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      185643130..185825042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447325.1XP_047303281.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X16

    2. XM_024453316.2XP_024309084.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X15

      Conserved Domains (3) summary
      cd00105
      Location:141206
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:294357
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cl17169
      Location:121
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. XM_047447317.1XP_047303273.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X5

    4. XM_017005557.3XP_016861046.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X1

    5. XM_047447321.1XP_047303277.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X10

    6. XM_047447316.1XP_047303272.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X4

      Conserved Domains (5) summary
      cd12626
      Location:278
      RRM1_IGF2BP2; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cd12629
      Location:82157
      RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)
      cd22491
      Location:195268
      KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cd22494
      Location:276352
      KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
      cl00098
      Location:426487
      KH-I; K homology (KH) RNA-binding domain, type I
    7. XM_047447319.1XP_047303275.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X8

    8. XM_017005558.3XP_016861047.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X2

    9. XM_017005559.3XP_016861048.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X3

    10. XM_047447322.1XP_047303278.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X12

    11. XM_047447323.1XP_047303279.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X13

    12. XM_047447318.1XP_047303274.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X7

    13. XM_017005560.3XP_016861049.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X6

    14. XM_047447326.1XP_047303282.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X16

    15. XM_047447320.1XP_047303276.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X9

    16. XM_047447328.1XP_047303284.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X15

    17. XM_047447329.1XP_047303285.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X20

      UniProtKB/TrEMBL
      B4DKT5
    18. XM_047447330.1XP_047303286.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X21

    19. XM_047447327.1XP_047303283.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X17

    20. XM_006713477.5XP_006713540.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X19

      See identical proteins and their annotated locations for XP_006713540.1

      UniProtKB/TrEMBL
      B4DKT5
      Conserved Domains (3) summary
      cd00105
      Location:2186
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:174237
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      cl02570
      Location:67112
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    21. XM_047447324.1XP_047303280.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X14

    22. XM_017005561.2XP_016861050.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X11

    23. XM_017005564.2XP_016861053.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X18

    24. XM_017005563.2XP_016861052.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X18

    RNA

    1. XR_007095624.1 RNA Sequence

    2. XR_001739984.3 RNA Sequence

    3. XR_007095628.1 RNA Sequence

    4. XR_007095626.1 RNA Sequence

    5. XR_007095625.1 RNA Sequence

    6. XR_007095627.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      188458961..188640755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344981.1XP_054200956.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X16

    2. XM_054344980.1XP_054200955.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X15

    3. XM_054344970.1XP_054200945.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X5

    4. XM_054344966.1XP_054200941.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X1

    5. XM_054344975.1XP_054200950.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X10

    6. XM_054344969.1XP_054200944.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X4

    7. XM_054344973.1XP_054200948.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X8

    8. XM_054344967.1XP_054200942.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X2

    9. XM_054344968.1XP_054200943.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X3

    10. XM_054344978.1XP_054200953.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X13

    11. XM_054344971.1XP_054200946.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X6

    12. XM_054344972.1XP_054200947.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X7

    13. XM_054344977.1XP_054200952.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X12

    14. XM_054344974.1XP_054200949.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X9

    15. XM_054344986.1XP_054200961.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X15

    16. XM_054344987.1XP_054200962.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X20

      UniProtKB/TrEMBL
      B4DKT5
    17. XM_054344988.1XP_054200963.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X21

    18. XM_054344982.1XP_054200957.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X17

    19. XM_054344985.1XP_054200960.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X19

      UniProtKB/TrEMBL
      B4DKT5
    20. XM_054344979.1XP_054200954.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X14

    21. XM_054344976.1XP_054200951.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X11

    22. XM_054344984.1XP_054200959.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X18

    23. XM_054344983.1XP_054200958.1  insulin-like growth factor 2 mRNA-binding protein 2 isoform X18

    RNA

    1. XR_008486631.1 RNA Sequence

    2. XR_008486630.1 RNA Sequence

    3. XR_008486635.1 RNA Sequence

    4. XR_008486633.1 RNA Sequence

    5. XR_008486632.1 RNA Sequence

    6. XR_008486634.1 RNA Sequence