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    NUDT11 nudix hydrolase 11 [ Homo sapiens (human) ]

    Gene ID: 55190, updated on 9-Dec-2024

    Summary

    Official Symbol
    NUDT11provided by HGNC
    Official Full Name
    nudix hydrolase 11provided by HGNC
    Primary source
    HGNC:HGNC:18011
    See related
    Ensembl:ENSG00000196368 MIM:300528; AllianceGenome:HGNC:18011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APS1; ASP1; DIPP3b; DIPP3beta; hDIPP3beta
    Summary
    NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in testis (RPKM 29.1), brain (RPKM 16.8) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NUDT11 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (51490011..51496592, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (50761304..50767871, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (51232863..51239444, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373204 Neighboring gene centromere protein V pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:51176173-51176672 Neighboring gene EZH inhibitory protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20851 Neighboring gene long intergenic non-protein coding RNA 1496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:51260667-51261167 Neighboring gene tRNA-Glu (CTC) 18-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
    EBI GWAS Catalog
    Multiple newly identified loci associated with prostate cancer susceptibility.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nudix (nucleoside diphosphate linked moiety X)-type motif 11 (NUDT11) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10628

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bis(5'-adenosyl)-hexaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables bis(5'-adenosyl)-pentaphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables diphosphoinositol-polyphosphate diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables diphosphoinositol-polyphosphate diphosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables endopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diadenosine hexaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diadenosine pentaphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in diphosphoinositol polyphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    diphosphoinositol polyphosphate phosphohydrolase 3-beta
    Names
    DIPP-3-beta
    DIPP3-beta
    diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta
    diadenosine hexaphosphate hydrolase (AMP-forming)
    diphosphoinositol polyphosphate phosphohydrolase 3, beta
    hAps1
    nucleoside diphosphate-linked moiety X motif 11
    nudix (nucleoside diphosphate linked moiety X)-type motif 11
    nudix motif 11
    NP_060629.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018159.4NP_060629.2  diphosphoinositol polyphosphate phosphohydrolase 3-beta

      Status: VALIDATED

      Source sequence(s)
      AL158055, BC009942, BX419815
      Consensus CDS
      CCDS43952.1
      UniProtKB/Swiss-Prot
      Q96G61, Q9NVN0
      UniProtKB/TrEMBL
      B2RE29
      Related
      ENSP00000365160.3, ENST00000375992.4
      Conserved Domains (1) summary
      cd04666
      Location:18137
      Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      51490011..51496592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      50761304..50767871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)