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    TSHZ2 teashirt zinc finger homeobox 2 [ Homo sapiens (human) ]

    Gene ID: 128553, updated on 9-Dec-2024

    Summary

    Official Symbol
    TSHZ2provided by HGNC
    Official Full Name
    teashirt zinc finger homeobox 2provided by HGNC
    Primary source
    HGNC:HGNC:13010
    See related
    Ensembl:ENSG00000182463 MIM:614118; AllianceGenome:HGNC:13010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSH2; ZABC2; ZNF218; OVC10-2; C20orf17
    Summary
    This gene is a member of the teashirt C2H2-type zinc-finger protein family of transcription factors. This gene encodes a protein with five C2H2-type zinc fingers, a homeobox DNA-binding domain and a coiled-coil domain. This nuclear protein is predicted to act as a transcriptional repressor. This gene is thought to play a role in the development and progression of breast and other types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
    Expression
    Ubiquitous expression in gall bladder (RPKM 3.9), ovary (RPKM 3.7) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TSHZ2 in Genome Data Viewer
    Location:
    20q13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (52972358..53495330)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (54743639..55267611)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (51588897..52111869)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372668 Neighboring gene ribosomal protein L36 pseudogene 1 Neighboring gene uncharacterized LOC124904932 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:51664301-51665500 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:51681690-51682889 Neighboring gene NANOG hESC enhancer GRCh37_chr20:51683526-51684027 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:51705255-51705481 Neighboring gene RN7SK pseudogene 184 Neighboring gene MPRA-validated peak4263 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13046 Neighboring gene Sharpr-MPRA regulatory region 1604 Neighboring gene Sharpr-MPRA regulatory region 9561 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:51898656-51899211 Neighboring gene NANOG hESC enhancer GRCh37_chr20:51899474-51900080 Neighboring gene Sharpr-MPRA regulatory region 12391 Neighboring gene uncharacterized LOC105372670 Neighboring gene Sharpr-MPRA regulatory region 11508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13047 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52077141-52077719 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52077720-52078297 Neighboring gene TSHZ2 antisense RNA 1 Neighboring gene peptidylprolyl isomerase A pseudogene 10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52089451-52090068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:52120609-52121259 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:52126933-52127434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:52127435-52127934 Neighboring gene uncharacterized LOC105372671 Neighboring gene reporter assay-validated silencer 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:52173455-52173955 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:52175886-52176069 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:52189693-52189843 Neighboring gene ZNF217 antisense RNA 1 Neighboring gene zinc finger protein 217

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
    EBI GWAS Catalog
    Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ33887, DKFZp686K2480

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    teashirt homolog 2
    Names
    cell growth-inhibiting protein 7
    ovarian cancer-related protein 10-2
    serologically defined colon cancer antigen 33 like
    teashirt family zinc finger 2
    zinc finger protein 218

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053184.1 RefSeqGene

      Range
      5050..528022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001193421.2NP_001180350.1  teashirt homolog 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK302570, AL354993, AL391097, BQ574274, BX276189
      Consensus CDS
      CCDS54474.1
      UniProtKB/Swiss-Prot
      Q9NRE2
      Related
      ENSP00000475114.1, ENST00000603338.2
      Conserved Domains (2) summary
      cd00086
      Location:839907
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00020
      Location:214236
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. NM_173485.6NP_775756.3  teashirt homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_775756.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL121902, AL354993, BQ574274, BX276189, BX640770
      Consensus CDS
      CCDS33490.1
      UniProtKB/Swiss-Prot
      B7Z7W1, J3KNQ0, Q4VXM4, Q6N003, Q8N260, Q9NRE2
      Related
      ENSP00000360552.3, ENST00000371497.10
      Conserved Domains (2) summary
      cd00086
      Location:842910
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      sd00020
      Location:217239
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      52972358..53495330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439875.1XP_047295831.1  teashirt homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7W1, J3KNQ0, Q4VXM4, Q6N003, Q8N260, Q9NRE2
    2. XM_047439874.1XP_047295830.1  teashirt homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7W1, J3KNQ0, Q4VXM4, Q6N003, Q8N260, Q9NRE2
    3. XM_047439873.1XP_047295829.1  teashirt homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7W1, J3KNQ0, Q4VXM4, Q6N003, Q8N260, Q9NRE2
    4. XM_047439876.1XP_047295832.1  teashirt homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7W1, J3KNQ0, Q4VXM4, Q6N003, Q8N260, Q9NRE2
    5. XM_047439877.1XP_047295833.1  teashirt homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7W1, J3KNQ0, Q4VXM4, Q6N003, Q8N260, Q9NRE2
    6. XM_017027641.2XP_016883130.1  teashirt homolog 2 isoform X2

    7. XM_047439878.1XP_047295834.1  teashirt homolog 2 isoform X2

    8. XM_047439879.1XP_047295835.1  teashirt homolog 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      54743639..55267611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322946.1XP_054178921.1  teashirt homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7W1, J3KNQ0, Q4VXM4, Q6N003, Q8N260, Q9NRE2
    2. XM_054322945.1XP_054178920.1  teashirt homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7W1, J3KNQ0, Q4VXM4, Q6N003, Q8N260, Q9NRE2
    3. XM_054322944.1XP_054178919.1  teashirt homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7W1, J3KNQ0, Q4VXM4, Q6N003, Q8N260, Q9NRE2
    4. XM_054322947.1XP_054178922.1  teashirt homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7W1, J3KNQ0, Q4VXM4, Q6N003, Q8N260, Q9NRE2
    5. XM_054322948.1XP_054178923.1  teashirt homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7W1, J3KNQ0, Q4VXM4, Q6N003, Q8N260, Q9NRE2
    6. XM_054322949.1XP_054178924.1  teashirt homolog 2 isoform X2

    7. XM_054322950.1XP_054178925.1  teashirt homolog 2 isoform X2

    8. XM_054322951.1XP_054178926.1  teashirt homolog 2 isoform X2