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    EPCIP exosomal polycystin 1 interacting protein [ Homo sapiens (human) ]

    Gene ID: 56245, updated on 9-Dec-2024

    Summary

    Official Symbol
    EPCIPprovided by HGNC
    Official Full Name
    exosomal polycystin 1 interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:1305
    See related
    Ensembl:ENSG00000205929 AllianceGenome:HGNC:1305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B37; CU062; PRED81; C21orf62; C21orf120
    Summary
    Involved in mitocytosis. Located in extracellular exosome and migrasome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary (RPKM 6.0), kidney (RPKM 3.0) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EPCIP in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (32790673..32813703, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (31156897..31179935, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34162984..34186013, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene synaptojanin 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:34100031-34100531 Neighboring gene PAXBP1 antisense RNA 1 Neighboring gene uncharacterized LOC124905010 Neighboring gene PAX3 and PAX7 binding protein 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:34143733-34144722 Neighboring gene EPCIP antisense RNA 1 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC124905012 Neighboring gene VISTA enhancer hs1548

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in migrasome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in migrasome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    exosomal polycystin-1-interacting protein
    Names
    polycystin-1-interacting protein 1
    uncharacterized protein C21orf62

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162495.3NP_001155967.2  exosomal polycystin-1-interacting protein precursor

      See identical proteins and their annotated locations for NP_001155967.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP000280, BC069689, BC069779, BE466137, DQ656042
      Consensus CDS
      CCDS42919.2
      UniProtKB/Swiss-Prot
      A8K4L8, Q9NYP8
      Related
      ENSP00000418653.1, ENST00000479548.2
      Conserved Domains (1) summary
      pfam15137
      Location:6219
      DUF4571; Domain of unknown function (DUF4571)
    2. NM_001162496.3NP_001155968.2  exosomal polycystin-1-interacting protein precursor

      See identical proteins and their annotated locations for NP_001155968.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP000280, BC069689, BC069709, BE466137, DQ656042
      Consensus CDS
      CCDS42919.2
      UniProtKB/Swiss-Prot
      A8K4L8, Q9NYP8
      Related
      ENSP00000418511.1, ENST00000487113.1
      Conserved Domains (1) summary
      pfam15137
      Location:6219
      DUF4571; Domain of unknown function (DUF4571)
    3. NM_019596.6NP_062542.5  exosomal polycystin-1-interacting protein precursor

      See identical proteins and their annotated locations for NP_062542.5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AP000280, BC069689, BE466137, DQ656042
      Consensus CDS
      CCDS42919.2
      UniProtKB/Swiss-Prot
      A8K4L8, Q9NYP8
      Related
      ENSP00000418830.1, ENST00000490358.5
      Conserved Domains (1) summary
      pfam15137
      Location:6219
      DUF4571; Domain of unknown function (DUF4571)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      32790673..32813703 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315969.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      21595..44610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      31156897..31179935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)