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    TRMT1L tRNA methyltransferase 1 like [ Homo sapiens (human) ]

    Gene ID: 81627, updated on 3-Dec-2024

    Summary

    Official Symbol
    TRMT1Lprovided by HGNC
    Official Full Name
    tRNA methyltransferase 1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:16782
    See related
    Ensembl:ENSG00000121486 MIM:611673; AllianceGenome:HGNC:16782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRM1L; MST070; C1orf25; MSTP070; bG120K12.3
    Summary
    This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. [provided by RefSeq, Jan 2011]
    Expression
    Broad expression in testis (RPKM 9.7), kidney (RPKM 3.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRMT1L in Genome Data Viewer
    Location:
    1q25.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (185118101..185157537, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (184475011..184514447, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (185087233..185126230, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:184985922-184987121 Neighboring gene RNA, 5S ribosomal pseudogene 72 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1643 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:185034115-185035314 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:185041955-185042087 Neighboring gene ring finger protein 2 Neighboring gene ferritin heavy chain 1 pseudogene 25 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:185125173-185126078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1645 Neighboring gene ribosomal protein L22 pseudogene 24 Neighboring gene SWT1 RNA endoribonuclease homolog Neighboring gene ribosomal protein L5 pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Interaction of HIV-1 Gag with tRNA methyltransferase 1 homolog (S. cerevisiae)-like (TRMT1L) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    Rev rev HIV-1 Rev interacting protein, TRMT1-like protein, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC25112, MGC57134

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tRNA (guanine) methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in tRNA N2-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    TRMT1-like protein
    Names
    TRM1 tRNA methyltransferase 1-like
    TRM1-like protein
    tRNA methyltransferase 1 homolog-like
    NP_001189352.1
    NP_112196.3
    XP_047287247.1
    XP_047287248.1
    XP_054194899.1
    XP_054194900.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202423.2NP_001189352.1  TRMT1-like protein isoform 2

      See identical proteins and their annotated locations for NP_001189352.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AF163261, AK074993, AK226103, AK302166, BU198525, DC398320
      UniProtKB/TrEMBL
      B4DXX1
      Conserved Domains (1) summary
      cl17173
      Location:95536
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    2. NM_030934.5NP_112196.3  TRMT1-like protein isoform 1

      See identical proteins and their annotated locations for NP_112196.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF288399, AK226103, BC045535, DB093548
      Consensus CDS
      CCDS1366.1
      UniProtKB/Swiss-Prot
      Q5TEN0, Q6ZMX0, Q7Z2T5, Q8IWH5, Q8NC68, Q9BZQ1
      UniProtKB/TrEMBL
      B2R713
      Related
      ENSP00000356476.5, ENST00000367506.10
      Conserved Domains (1) summary
      cl17173
      Location:251692
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      185118101..185157537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431291.1XP_047287247.1  TRMT1-like protein isoform X1

      UniProtKB/TrEMBL
      B4DXX1
    2. XM_047431292.1XP_047287248.1  TRMT1-like protein isoform X1

      UniProtKB/TrEMBL
      B4DXX1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      184475011..184514447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338924.1XP_054194899.1  TRMT1-like protein isoform X1

      UniProtKB/TrEMBL
      B4DXX1
    2. XM_054338925.1XP_054194900.1  TRMT1-like protein isoform X1

      UniProtKB/TrEMBL
      B4DXX1