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    GPR173 G protein-coupled receptor 173 [ Homo sapiens (human) ]

    Gene ID: 54328, updated on 27-Nov-2024

    Summary

    Official Symbol
    GPR173provided by HGNC
    Official Full Name
    G protein-coupled receptor 173provided by HGNC
    Primary source
    HGNC:HGNC:18186
    See related
    Ensembl:ENSG00000184194 MIM:300253; AllianceGenome:HGNC:18186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SREB3
    Summary
    This gene encodes a member of the G-protein coupled receptor 1 family. This protein contains 7 transmembrane domains and conserved cysteine residues. [provided by RefSeq, Nov 2009]
    Expression
    Broad expression in brain (RPKM 6.2), ovary (RPKM 2.6) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GPR173 in Genome Data Viewer
    Location:
    Xp11.22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (53048789..53080615)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (52333387..52366851)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (53077971..53109797)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29649 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52963212-52964184 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:52964185-52965156 Neighboring gene family with sequence similarity 156 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53018839-53019418 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:53045322-53045423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:53100667-53101168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20854 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:53122416-53123240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20855 Neighboring gene TSPY like 2 Neighboring gene KANTR integral membrane protein Neighboring gene RNA, U7 small nuclear 37 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables gonadotropin-releasing hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to gonadotropin-releasing hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    probable G-protein coupled receptor 173
    Names
    super conserved receptor expressed in brain 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015966.1 RefSeqGene

      Range
      4466..36292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_018969.6NP_061842.1  probable G-protein coupled receptor 173

      See identical proteins and their annotated locations for NP_061842.1

      Status: REVIEWED

      Source sequence(s)
      BX322635
      Consensus CDS
      CCDS14349.1
      UniProtKB/Swiss-Prot
      B1B0A5, Q9NS66
      Related
      ENSP00000331600.5, ENST00000332582.5
      Conserved Domains (1) summary
      cd15217
      Location:23351
      7tmA_SREB3_GPR173; super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      53048789..53080615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442184.1XP_047298140.1  probable G-protein coupled receptor 173 isoform X1

      UniProtKB/Swiss-Prot
      B1B0A5, Q9NS66

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      52333387..52366851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327255.1XP_054183230.1  probable G-protein coupled receptor 173 isoform X1

      UniProtKB/Swiss-Prot
      B1B0A5, Q9NS66