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    KLK15 kallikrein related peptidase 15 [ Homo sapiens (human) ]

    Gene ID: 55554, updated on 3-Dec-2024

    Summary

    Official Symbol
    KLK15provided by HGNC
    Official Full Name
    kallikrein related peptidase 15provided by HGNC
    Primary source
    HGNC:HGNC:20453
    See related
    Ensembl:ENSG00000174562 MIM:610601; AllianceGenome:HGNC:20453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACO; HSRNASPH
    Summary
    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in colon (RPKM 1.2), testis (RPKM 1.0) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KLK15 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (50825289..50833574, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (53914924..53923210, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51328545..51336830, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10979 Neighboring gene transmembrane protein 277, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15001 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15002 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10980 Neighboring gene kallikrein 1 Neighboring gene uncharacterized LOC105372441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10981 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10982 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51343676-51343863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51347149-51347671 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51347672-51348193 Neighboring gene KLK3 upstream enhancer/promoter region Neighboring gene kallikrein related peptidase 3 Neighboring gene KLK2 upstream enhancer/promoter region Neighboring gene origin of replication 20mer2 Neighboring gene kallikrein related peptidase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.
    EBI GWAS Catalog
    Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables serine-type peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    kallikrein-15
    Names
    ACO protease
    kallikrein-like serine protease
    prostinogen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029894.1 RefSeqGene

      Range
      2950..11235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001277081.2NP_001264010.1  kallikrein-15 isoform 5 preproprotein

      See identical proteins and their annotated locations for NP_001264010.1

      Status: REVIEWED

      Source sequence(s)
      AC010325
      Consensus CDS
      CCDS62766.1
      UniProtKB/TrEMBL
      Q96RQ0
      Related
      ENSP00000512319.1, ENST00000695998.1
      Conserved Domains (2) summary
      smart00020
      Location:24248
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:24251
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_001277082.2NP_001264011.1  kallikrein-15 isoform 6 preproprotein

      See identical proteins and their annotated locations for NP_001264011.1

      Status: REVIEWED

      Source sequence(s)
      AC010325
      Consensus CDS
      CCDS12806.2
      UniProtKB/TrEMBL
      M0R0D7, Q6UBM2
      Related
      ENSP00000471164.1, ENST00000596931.5
      Conserved Domains (2) summary
      smart00020
      Location:24150
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:24150
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. NM_017509.4NP_059979.2  kallikrein-15 isoform 4 preproprotein

      See identical proteins and their annotated locations for NP_059979.2

      Status: REVIEWED

      Source sequence(s)
      AC010325
      Consensus CDS
      CCDS12805.1
      UniProtKB/Swiss-Prot
      A0AUY8, Q15358, Q6ISI0, Q9H2R3, Q9H2R4, Q9H2R5, Q9H2R6, Q9HBG9
      UniProtKB/TrEMBL
      Q96RQ0
      Related
      ENSP00000469315.1, ENST00000598239.6
      Conserved Domains (1) summary
      smart00020
      Location:25249
      Tryp_SPc; Trypsin-like serine protease

    RNA

    1. NR_102274.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site in two internal exons, compared to variant 4. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 4, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AW205420, AY373373, BC069518, BC144045
      Related
      ENST00000695963.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      50825289..50833574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439064.1XP_047295020.1  kallikrein-15 isoform X2

      UniProtKB/TrEMBL
      A0A6B7HEB8
      Conserved Domains (1) summary
      cd00190
      Location:24166
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. XM_011527087.3XP_011525389.1  kallikrein-15 isoform X1

      See identical proteins and their annotated locations for XP_011525389.1

      UniProtKB/TrEMBL
      A0A6B7HBY5
      Related
      ENSP00000512291.1, ENST00000695965.1
      Conserved Domains (1) summary
      cd00190
      Location:25167
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    3. XM_011527088.3XP_011525390.1  kallikrein-15 isoform X3

      See identical proteins and their annotated locations for XP_011525390.1

      UniProtKB/TrEMBL
      Q6UBM2
      Conserved Domains (2) summary
      smart00020
      Location:25151
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:25151
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    4. XM_017026943.2XP_016882432.1  kallikrein-15 isoform X4

      UniProtKB/TrEMBL
      M0QX22
      Related
      ENSP00000468856.1, ENST00000602114.1
      Conserved Domains (2) summary
      smart00020
      Location:25120
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:25120
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      53914924..53923210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321400.1XP_054177375.1  kallikrein-15 isoform X2

      UniProtKB/TrEMBL
      A0A6B7HEB8
    2. XM_054321399.1XP_054177374.1  kallikrein-15 isoform X1

      UniProtKB/TrEMBL
      A0A6B7HBY5
    3. XM_054321401.1XP_054177376.1  kallikrein-15 isoform X3

      UniProtKB/TrEMBL
      Q6UBM2
    4. XM_054321402.1XP_054177377.1  kallikrein-15 isoform X4

      UniProtKB/TrEMBL
      M0QX22

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_023006.1: Suppressed sequence

      Description
      NM_023006.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    2. NM_138563.1: Suppressed sequence

      Description
      NM_138563.1: This RefSeq was permanently suppressed because currently there is insufficient support for the exon combination represented in this variant.
    3. NM_138564.1: Suppressed sequence

      Description
      NM_138564.1: This RefSeq was permanently suppressed because currently there is insufficient support for the exon combination represented in this variant.