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    KLK5 kallikrein related peptidase 5 [ Homo sapiens (human) ]

    Gene ID: 25818, updated on 3-Dec-2024

    Summary

    Official Symbol
    KLK5provided by HGNC
    Official Full Name
    kallikrein related peptidase 5provided by HGNC
    Primary source
    HGNC:HGNC:6366
    See related
    Ensembl:ENSG00000167754 MIM:605643; AllianceGenome:HGNC:6366
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCTE; KLKL2; KLK-L2
    Summary
    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in skin (RPKM 70.7), lung (RPKM 6.1) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See KLK5 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (50943303..50953038, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54031364..54041157, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51446559..51456294, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 4 Neighboring gene peptidylprolyl isomerase A pseudogene 59 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51442294-51442457 Neighboring gene uncharacterized LOC105372442 Neighboring gene kallikrein related peptidase 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51486908-51487462 Neighboring gene kallikrein related peptidase 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables serine-type peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in amelogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cornification TAS
    Traceable Author Statement
    more info
     
    involved_in epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in extracellular matrix disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of antibacterial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in epidermal lamellar body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    kallikrein-5
    Names
    kallikrein-like protein 2
    stratum corneum tryptic enzyme

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077491.2NP_001070959.1  kallikrein-5 preproprotein

      See identical proteins and their annotated locations for NP_001070959.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AY279381, AY359010
      Consensus CDS
      CCDS12810.1
      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68
      Related
      ENSP00000375685.1, ENST00000391809.6
      Conserved Domains (1) summary
      smart00020
      Location:66285
      Tryp_SPc; Trypsin-like serine protease
    2. NM_001077492.2NP_001070960.1  kallikrein-5 preproprotein

      See identical proteins and their annotated locations for NP_001070960.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      AY359010
      Consensus CDS
      CCDS12810.1
      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68
      Related
      ENSP00000471966.1, ENST00000593428.5
      Conserved Domains (1) summary
      smart00020
      Location:66285
      Tryp_SPc; Trypsin-like serine protease
    3. NM_012427.5NP_036559.1  kallikrein-5 preproprotein

      See identical proteins and their annotated locations for NP_036559.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
      Source sequence(s)
      AY359010
      Consensus CDS
      CCDS12810.1
      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68
      Related
      ENSP00000337733.2, ENST00000336334.8
      Conserved Domains (1) summary
      smart00020
      Location:66285
      Tryp_SPc; Trypsin-like serine protease

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      50943303..50953038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526702.2XP_011525004.1  kallikrein-5 isoform X1

      See identical proteins and their annotated locations for XP_011525004.1

      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68
      Conserved Domains (1) summary
      smart00020
      Location:66285
      Tryp_SPc; Trypsin-like serine protease
    2. XM_011526703.3XP_011525005.1  kallikrein-5 isoform X1

      See identical proteins and their annotated locations for XP_011525005.1

      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68
      Conserved Domains (1) summary
      smart00020
      Location:66285
      Tryp_SPc; Trypsin-like serine protease

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54031364..54041157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320472.1XP_054176447.1  kallikrein-5 isoform X1

      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68
    2. XM_054320473.1XP_054176448.1  kallikrein-5 isoform X1

      UniProtKB/Swiss-Prot
      A0A024R4G4, Q9HBG8, Q9Y337
      UniProtKB/TrEMBL
      Q53F68