RAB11FIP4 RAB11 family interacting protein 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB11FIP4provided by HGNC
Official Full Name: RAB11 family interacting protein 4provided by HGNC
Primary source: HGNC:HGNC:30267
See related: Ensembl:ENSG00000131242 MIM:611999; AllianceGenome:HGNC:30267
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FIP4-Rab11; RAB11-FIP4
Summary: The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]
Expression: Broad expression in brain (RPKM 25.4), testis (RPKM 6.0) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q11.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (31391675..31538211)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (32337033..32483971)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (29718693..29865230)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab11 FIP4 was also discovered through a yeast two-hybrid screen for Arf5 effectors and named Arfophilin-2, as described here. Rab11 FIP4/Arfophilin-2 was shown to localize to a perinuclear compartment, the centrosome, and focal adhesions in HeLa cells. Rab11 FIP4/Arfophilin-2 over-expression was shown to cluster the Rab11-positive endosomal recycling compartment around the centrosome.
Title: Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout.
Rab11-FIP4 expression promotes migration and invasion of colon cancer cells and correlates with poor prognosis.
Title: Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis.
Our findings suggest that overexpression of Rab11-FIP4 predicts poor clinical outcomes for pancreatic cancer and contributes to pancreatic tumor progression.
Title: High Rab11-FIP4 expression predicts poor prognosis and exhibits tumor promotion in pancreatic cancer.
Results show the expression of Rab11-FIP4 upregulated in hepatocellular carcinoma (HCC) and correlated with poor prognosis. Rab11-FIP4 dramatically contributed to HCC metastasis via phosphorylation of PRAS40.
Title: Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinoma.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
FIP3 and FIP4 serve to couple Rab11-positive vesicle traffic from recycling endosomes to the cleavage furrow/midbody where they are tethered prior to fusion events via interactions with Arf6 and the Exocyst.
Title: Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis.
Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells.
Title: Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH18392 (e-PCR)
- UniSTS:44556

D17S1972 (e-PCR)
- UniSTS:31511

IB518 (e-PCR)
- UniSTS:57367

RH91562 (e-PCR)
- UniSTS:90930

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-8060 (e-PCR)
- UniSTS:63550

WI-18876 (e-PCR)
- UniSTS:24898

Cda0zg05 (e-PCR)
- UniSTS:4939

WIAF-1519 (e-PCR)
- UniSTS:74572

STS-M79255 (e-PCR)
- UniSTS:33362

RH78318 (e-PCR)
- UniSTS:9054

SGC30494 (e-PCR)
- UniSTS:58977

D1S1423 (e-PCR)
- UniSTS:149619

SHGC-83604 (e-PCR)
- UniSTS:95894

G60284 (e-PCR)
- UniSTS:137389

SHGC-57602 (e-PCR)
- UniSTS:37042

RH69351 (e-PCR)
- UniSTS:21688

RH78102 (e-PCR)
- UniSTS:55769

D17S1681 (e-PCR)
- UniSTS:29659

D17S145 (e-PCR)
- UniSTS:146911

RAB11-FIP4__5629 (e-PCR)
- UniSTS:463843

D5S1621E (e-PCR)
- UniSTS:151034

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural retina development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G1 to G0 transition	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in recycling endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rab11 family-interacting protein 4

Names: RAB11 family interacting protein 4 (class II); arfophilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051977.1 RefSeqGene

Range

5052..151588

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001303542.3 → NP_001290471.2 rab11 family-interacting protein 4 isoform 2

See identical proteins and their annotated locations for NP_001290471.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AB058724, AJ314646, AK097424, AL831830, BC047674

Consensus CDS

CCDS76985.1

UniProtKB/Swiss-Prot

Q86YS3

Related

ENSP00000378227.2, ENST00000394744.6

Conserved Domains (2) summary

COG1196
Location:238 → 519

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09457
Location:494 → 534

RBD-FIP; FIP domain
NM_001346747.2 → NP_001333676.1 rab11 family-interacting protein 4 isoform 3

Status: REVIEWED

Source sequence(s)

AC003101, KF510421
NM_001346748.2 → NP_001333677.1 rab11 family-interacting protein 4 isoform 4

Status: REVIEWED

Source sequence(s)

AC003101, AJ314646, KF510421

UniProtKB/Swiss-Prot

Q86YS3

Conserved Domains (2) summary

pfam09457
Location:455 → 495

RBD-FIP; FIP domain

cl25732
Location:199 → 480

SMC_N; RecF/RecN/SMC N terminal domain
NM_001346749.2 → NP_001333678.1 rab11 family-interacting protein 4 isoform 5

Status: REVIEWED

Source sequence(s)

AC003101, AJ314646, DA956442, KF510421

UniProtKB/Swiss-Prot

Q86YS3

Conserved Domains (2) summary

pfam09457
Location:336 → 376

RBD-FIP; FIP domain

cl25732
Location:80 → 361

SMC_N; RecF/RecN/SMC N terminal domain
NM_032932.6 → NP_116321.2 rab11 family-interacting protein 4 isoform 1

See identical proteins and their annotated locations for NP_116321.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AJ314646, AY169244, BC047674, BC093914

Consensus CDS

CCDS11267.1

UniProtKB/Swiss-Prot

Q52LI1, Q86YS3, Q8N829, Q8NDT7, Q969D8

Related

ENSP00000482620.1, ENST00000621161.5

Conserved Domains (3) summary

COG1196
Location:340 → 621

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09457
Location:596 → 636

RBD-FIP; FIP domain

pfam13499
Location:20 → 78

EF-hand_7; EF-hand domain pair