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    SARAF store-operated calcium entry associated regulatory factor [ Homo sapiens (human) ]

    Gene ID: 51669, updated on 9-Dec-2024

    Summary

    Official Symbol
    SARAFprovided by HGNC
    Official Full Name
    store-operated calcium entry associated regulatory factorprovided by HGNC
    Primary source
    HGNC:HGNC:28789
    See related
    Ensembl:ENSG00000133872 MIM:614768; AllianceGenome:HGNC:28789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    XTP3; FOAP-7; TMEM66; HSPC035
    Summary
    Involved in regulation of store-operated calcium entry. Located in endoplasmic reticulum membrane and endoplasmic reticulum-plasma membrane contact site. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 148.3), adrenal (RPKM 121.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SARAF in Genome Data Viewer
    Location:
    8p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (30063003..30083208, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (30341918..30362124, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (29920519..29940724, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:29890859-29891680 Neighboring gene mitogen-activated protein kinase kinase 1 pseudogene 1 Neighboring gene RNA, U6 small nuclear 1218, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:29914456-29915655 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19075 Neighboring gene leptin receptor overlapping transcript like 1 Neighboring gene ribosomal protein S15a pseudogene 24 Neighboring gene membrane bound O-acyltransferase domain containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of transmembrane protein 66 (TMEM66) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC8721, FLJ22274

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of store-operated calcium entry IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum-plasma membrane contact site IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    store-operated calcium entry-associated regulatory factor
    Names
    HBV X-transactivated gene 3 protein
    HBV XAg-transactivated protein 3
    SOCE-associated regulatory factor
    testicular secretory protein Li 59
    transmembrane protein 66

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284239.1NP_001271168.1  store-operated calcium entry-associated regulatory factor isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC044849, AK315956, BM280420, DC359554
      Consensus CDS
      CCDS64866.1
      UniProtKB/TrEMBL
      B3KSV1
      Related
      ENSP00000441351.1, ENST00000545648.2
      Conserved Domains (1) summary
      pfam06682
      Location:2167
      SARAF; SOCE-associated regulatory factor of calcium homoeostasis
    2. NM_016127.6NP_057211.4  store-operated calcium entry-associated regulatory factor isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC044849
      Consensus CDS
      CCDS6074.1
      UniProtKB/Swiss-Prot
      B3KQQ4, B7Z9J1, D3DSU7, H9MHJ8, H9MHJ9, Q53HE8, Q96BY9, Q9UNZ3, Q9Y683
      UniProtKB/TrEMBL
      A0A140VK59, B7Z307
      Related
      ENSP00000256255.6, ENST00000256255.11
      Conserved Domains (1) summary
      pfam06682
      Location:24339
      SARAF; SOCE-associated regulatory factor of calcium homoeostasis

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      30063003..30083208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      30341918..30362124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)