U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    DCTN6 dynactin subunit 6 [ Homo sapiens (human) ]

    Gene ID: 10671, updated on 27-Nov-2024

    Summary

    Official Symbol
    DCTN6provided by HGNC
    Official Full Name
    dynactin subunit 6provided by HGNC
    Primary source
    HGNC:HGNC:16964
    See related
    Ensembl:ENSG00000104671 MIM:612963; AllianceGenome:HGNC:16964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WS3; p27; WS-3
    Summary
    The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 33.5), fat (RPKM 26.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DCTN6 in Genome Data Viewer
    Location:
    8p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (30156369..30183639)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (30435240..30462514)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (30013885..30041155)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene leptin receptor overlapping transcript like 1 Neighboring gene ribosomal protein S15a pseudogene 24 Neighboring gene membrane bound O-acyltransferase domain containing 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:30013010-30013992 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19076 Neighboring gene uncharacterized LOC124901927 Neighboring gene DCTN6 divergent transcript Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:30061632-30062299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:30068419-30068920 Neighboring gene uncharacterized LOC124901928 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 11 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:30106253-30107452 Neighboring gene transgelin 2 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dynactin subunit 6
    Names
    dynactin 6
    dynactin subunit p27
    novel RGD-containing protein
    protein WS-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006571.4NP_006562.1  dynactin subunit 6

      See identical proteins and their annotated locations for NP_006562.1

      Status: REVIEWED

      Source sequence(s)
      BC013175, D79389
      Consensus CDS
      CCDS6076.1
      UniProtKB/Swiss-Prot
      B2RAC1, O00399
      UniProtKB/TrEMBL
      E5RK00
      Related
      ENSP00000221114.3, ENST00000221114.8
      Conserved Domains (1) summary
      cd04646
      Location:10179
      LbH_Dynactin_6; Dynactin 6 (or subunit p27): Dynactin is a major component of the activator complex that stimulates dynein-mediated vesicle transport. Dynactin is a heterocomplex of at least eight subunits, including a 150,000-MW protein called Glued, the actin-capping ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      30156369..30183639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      30435240..30462514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)