PLA2G2A phospholipase A2 group IIA [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLA2G2Aprovided by HGNC
Official Full Name: phospholipase A2 group IIAprovided by HGNC
Primary source: HGNC:HGNC:9031
See related: Ensembl:ENSG00000188257 MIM:172411; AllianceGenome:HGNC:9031
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
Summary: The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Expression: Biased expression in colon (RPKM 828.3), small intestine (RPKM 526.6) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (19975431..19980434, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (19799116..19804113, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (20301924..20306927, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High expression of PLA2G2A in fibroblasts plays a crucial role in the early progression of carotid atherosclerosis.
Title: High expression of PLA2G2A in fibroblasts plays a crucial role in the early progression of carotid atherosclerosis.
Identification and immunological characterization of PLA2G2A and cell death-associated molecular clusters in idiopathic pulmonary fibrosis.
Title: Identification and immunological characterization of PLA2G2A and cell death-associated molecular clusters in idiopathic pulmonary fibrosis.
[Diagnostic value of lipoprotein-associated phospholipase A2 in OPBR combined with gallbladder cholesterol deposition].
Title: [Diagnostic value of lipoprotein-associated phospholipase A2 in OPBR combined with gallbladder cholesterol deposition].
Secretory Phospholipase A2 and Interleukin-6 Levels as Predictive Markers of the Severity and Outcome of Patients with COVID-19 Infections.
Title: Secretory Phospholipase A2 and Interleukin-6 Levels as Predictive Markers of the Severity and Outcome of Patients with COVID-19 Infections.
Interplay between C1-inhibitor and group IIA secreted phospholipase A2 impairs their respective function.
Title: Interplay between C1-inhibitor and group IIA secreted phospholipase A(2) impairs their respective function.
PLA2G2A Phospholipase Promotes Fatty Acid Synthesis and Energy Metabolism in Pancreatic Cancer Cells with K-ras Mutation.
Title: PLA2G2A Phospholipase Promotes Fatty Acid Synthesis and Energy Metabolism in Pancreatic Cancer Cells with K-ras Mutation.
Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A2s.
Title: Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A(2)s.
Elevated lipoprotein(a) and lipoprotein-associated phospholipase A2 are associated with unfavorable functional outcomes in patients with ischemic stroke.
Title: Elevated lipoprotein(a) and lipoprotein-associated phospholipase A(2) are associated with unfavorable functional outcomes in patients with ischemic stroke.
Secretory Phospholipase A2 Digital Expression Analysis in Colon Adenocarcinoma.
Title: Secretory Phospholipase A2 Digital Expression Analysis in Colon Adenocarcinoma.
A novel prognosis prediction model, including cytotoxic T lymphocyte-associated antigen-4, ischemia-modified albumin, lipoprotein-associated phospholipase A2, glial fibrillary acidic protein, and homocysteine, for ischemic stroke in the Chinese hypertensive population.
Title: A novel prognosis prediction model, including cytotoxic T lymphocyte-associated antigen-4, ischemia-modified albumin, lipoprotein-associated phospholipase A2, glial fibrillary acidic protein, and homocysteine, for ischemic stroke in the Chinese hypertensive population.

Submit: New GeneRIF Correction See all GeneRIFs (175)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Colorectal cancer MedGen: C0346629 OMIM: 114500 GeneReviews: Lynch Syndrome	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor	PubMed
	env	HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipase A2 activity	TAS Traceable Author Statement more info	PubMed
enables calcium-independent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in intestinal stem cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle remodeling	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylcholine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylethanolamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of macrophage derived foam cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of neutrophil activation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in secretory granule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipase A2, membrane associated

Names: GIIC sPLA2; NPS-PLA2; group IIA phospholipase A2; non-pancreatic secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; phospholipase A2, group IIA (platelets, synovial fluid)

NP_000291.1

EC 3.1.1.4

NP_001155199.1

EC 3.1.1.4

NP_001155200.1

EC 3.1.1.4

NP_001155201.1

EC 3.1.1.4

NP_001382392.1

EC 3.1.1.4

XP_047278549.1

EC 3.1.1.4

XP_047278550.1

EC 3.1.1.4

XP_047278551.1

EC 3.1.1.4

XP_054193052.1

EC 3.1.1.4

XP_054193053.1

EC 3.1.1.4

XP_054193054.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012928.1 RefSeqGene

Range

5822..10005

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000300.4 → NP_000291.1 phospholipase A2, membrane associated precursor

See identical proteins and their annotated locations for NP_000291.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant and longest transcript. Variants 1-4 encode the same protein.

Source sequence(s)

BC005919, BU626291, BX641714

Consensus CDS

CCDS201.1

UniProtKB/Swiss-Prot

A8K5I7, P14555, Q6DN24, Q6IBD9, Q9UCD2

UniProtKB/TrEMBL

Q6DN23

Related

ENSP00000364252.3, ENST00000375111.7

Conserved Domains (1) summary

cd00125
Location:21 → 137

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
NM_001161727.2 → NP_001155199.1 phospholipase A2, membrane associated precursor

See identical proteins and their annotated locations for NP_001155199.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate acceptor splice site at one of the 5' non-coding exons compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

BU626291, BX641714, CB132375

Consensus CDS

CCDS201.1

UniProtKB/Swiss-Prot

A8K5I7, P14555, Q6DN24, Q6IBD9, Q9UCD2

UniProtKB/TrEMBL

Q6DN23

Conserved Domains (1) summary

cd00125
Location:21 → 137

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
NM_001161728.2 → NP_001155200.1 phospholipase A2, membrane associated precursor

See identical proteins and their annotated locations for NP_001155200.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) is missing one of the 5' non-coding exons compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

BC005919, BU626291, BX641714

Consensus CDS

CCDS201.1

UniProtKB/Swiss-Prot

A8K5I7, P14555, Q6DN24, Q6IBD9, Q9UCD2

UniProtKB/TrEMBL

Q6DN23

Conserved Domains (1) summary

cd00125
Location:21 → 137

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
NM_001161729.1 → NP_001155201.1 phospholipase A2, membrane associated precursor

See identical proteins and their annotated locations for NP_001155201.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate acceptor splice site in the 5' non-coding region compared to variant 1. Variants 1-4 encode the same protein.

Source sequence(s)

BC005919, BM708748, BU626291

Consensus CDS

CCDS201.1

UniProtKB/Swiss-Prot

A8K5I7, P14555, Q6DN24, Q6IBD9, Q9UCD2

UniProtKB/TrEMBL

Q6DN23

Related

ENSP00000383364.3, ENST00000400520.8

Conserved Domains (1) summary

cd00125
Location:21 → 137

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
NM_001395463.1 → NP_001382392.1 phospholipase A2, membrane associated precursor

Status: REVIEWED

Source sequence(s)

AL358253

Consensus CDS

CCDS201.1

UniProtKB/Swiss-Prot

A8K5I7, P14555, Q6DN24, Q6IBD9, Q9UCD2

UniProtKB/TrEMBL

Q6DN23

Related

ENSP00000504762.1, ENST00000482011.3

Conserved Domains (1) summary

cd00125
Location:21 → 137

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

19975431..19980434 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047422595.1 → XP_047278551.1 phospholipase A2, membrane associated isoform X1

UniProtKB/Swiss-Prot

A8K5I7, P14555, Q6DN24, Q6IBD9, Q9UCD2

UniProtKB/TrEMBL

Q6DN23
XM_047422593.1 → XP_047278549.1 phospholipase A2, membrane associated isoform X1

UniProtKB/Swiss-Prot

A8K5I7, P14555, Q6DN24, Q6IBD9, Q9UCD2

UniProtKB/TrEMBL

Q6DN23
XM_047422594.1 → XP_047278550.1 phospholipase A2, membrane associated isoform X1

UniProtKB/Swiss-Prot

A8K5I7, P14555, Q6DN24, Q6IBD9, Q9UCD2

UniProtKB/TrEMBL

Q6DN23

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

19799116..19804113 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054337079.1 → XP_054193054.1 phospholipase A2, membrane associated isoform X1

UniProtKB/Swiss-Prot

A8K5I7, P14555, Q6DN24, Q6IBD9, Q9UCD2

UniProtKB/TrEMBL

Q6DN23
XM_054337077.1 → XP_054193052.1 phospholipase A2, membrane associated isoform X1

UniProtKB/Swiss-Prot

A8K5I7, P14555, Q6DN24, Q6IBD9, Q9UCD2

UniProtKB/TrEMBL

Q6DN23
XM_054337078.1 → XP_054193053.1 phospholipase A2, membrane associated isoform X1

UniProtKB/Swiss-Prot

A8K5I7, P14555, Q6DN24, Q6IBD9, Q9UCD2

UniProtKB/TrEMBL

Q6DN23