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    ICAM5 intercellular adhesion molecule 5 [ Homo sapiens (human) ]

    Gene ID: 7087, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ICAM5provided by HGNC
    Official Full Name
    intercellular adhesion molecule 5provided by HGNC
    Primary source
    HGNC:HGNC:5348
    See related
    Ensembl:ENSG00000105376 MIM:601852; AllianceGenome:HGNC:5348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TLN; TLCN
    Summary
    The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 11.7), lung (RPKM 3.3) and 1 other tissue See more
    Orthologs
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    Genomic context

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    See ICAM5 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10289952..10296778)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10415547..10422890)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10400628..10407454)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene lncRNA inflammatory and mucous response associated, antisense to ICAM1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13953 Neighboring gene intercellular adhesion molecule 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10397303-10398272 Neighboring gene ICAM4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:10402483-10403475 Neighboring gene intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) Neighboring gene CRISPRi-validated cis-regulatory element chr19.1775 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:10415538-10416737 Neighboring gene FDX2-ZGLP1 readthrough Neighboring gene zinc finger GATA like protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10064 Neighboring gene ferredoxin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Telencephalin: a neuronal area code molecule? Yoshihara Y, et al. Neurosci Res, 1994 Dec. PMID 7724062
    2. The genetic polymorphisms of intercellular cell adhesion molecules and breast cancer susceptibility: a meta-analysis. Liu L, et al. Mol Biol Rep, 2013 Feb. PMID 23079714
    3. Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion. Tian L, et al. J Cell Biol, 2000 Jul 10. PMID 10893271, Free PMC Article
    4. Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18. Tian L, et al. Eur J Immunol, 2000 Mar. PMID 10741396
    5. ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68. Wei W, et al. Cell Host Microbe, 2016 Nov 9. PMID 27923705

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here the authors identify neuron-specific intercellular adhesion molecule 5 (ICAM-5/telencephalin) as a cellular receptor for sialic acid-dependent and -independent entry of enterovirus D68.
      Title: ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68.
    2. ICAM5 V301I and rs281439 variants may contribute to the susceptibility of breast cancer. [Meta-analysis]
      Title: The genetic polymorphisms of intercellular cell adhesion molecules and breast cancer susceptibility: a meta-analysis.
    3. A specific microenvironment facilitating ARF6-mediated mobilization of TLN that contributes to promotion of dendritic spine development.
      Title: ARF6-mediated endosomal transport of Telencephalin affects dendritic filopodia-to-spine maturation.
    4. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.
    5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
    6. ICAM-5 is involved in immune privilege of the brain and acts as an anti-inflammatory agent.
      Title: Shedded neuronal ICAM-5 suppresses T-cell activation.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
    8. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: ICAM gene cluster SNPs and prostate cancer risk in African Americans.
    9. study does not confirm association between ICAM 5 V3001 polymorphism and breast cancer risk
      Title: Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    intercellular adhesion molecule 5
    Names
    ICAM-5
    intercellular adhesion molecule 5, telencephalin
    telencephalin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003259.4 → NP_003250.3  intercellular adhesion molecule 5 precursor

      See identical proteins and their annotated locations for NP_003250.3

      Status: REVIEWED

      Source sequence(s)
      AC011511, AI199660, AI568610, BC030132, U72671
      Consensus CDS
      CCDS12233.1
      UniProtKB/Swiss-Prot
      Q9UMF0, Q9Y6F3
      UniProtKB/TrEMBL
      Q8TAM9
      Related
      ENSP00000221980.3, ENST00000221980.5
      Conserved Domains (6) summary
      cd05755
      Location:120 → 219
      Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
      smart00408
      Location:761 → 821
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:759 → 831
      IG_like; Immunoglobulin like
      pfam03921
      Location:31 → 103
      ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
      pfam13895
      Location:325 → 404
      Ig_2; Immunoglobulin domain
      cl11960
      Location:512 → 570
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10289952..10296778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10415547..10422890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321900.1 → XP_054177875.1  intercellular adhesion molecule 5 isoform X1

      UniProtKB/Swiss-Prot
      Q9UMF0, Q9Y6F3
      UniProtKB/TrEMBL
      Q8TAM9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UMF0.3 GenPept UniProtKB/Swiss-Prot:Q9UMF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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