U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    EVI2B ecotropic viral integration site 2B [ Homo sapiens (human) ]

    Gene ID: 2124, updated on 9-Dec-2024

    Summary

    Official Symbol
    EVI2Bprovided by HGNC
    Official Full Name
    ecotropic viral integration site 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:3500
    See related
    Ensembl:ENSG00000185862 MIM:158381; AllianceGenome:HGNC:3500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EVDB; CD361; D17S376
    Summary
    Involved in positive regulation of granulocyte differentiation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lymph node (RPKM 78.2), spleen (RPKM 77.3) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EVI2B in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (31303770..31314054, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (32249455..32259731, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29630788..29641072, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene uncharacterized LOC101927057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12010 Neighboring gene oligodendrocyte myelin glycoprotein Neighboring gene ecotropic viral integration site 2A Neighboring gene adenylate kinase 4 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ecotropic viral integration site 2B (EVI2B) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in myeloid cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of granulocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neutrophil differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neutrophil differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of stem cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of stem cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    protein EVI2B
    Names
    EVI-2B
    ecotropic viral integration site 2B protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006495.4NP_006486.3  protein EVI2B precursor

      See identical proteins and their annotated locations for NP_006486.3

      Status: VALIDATED

      Source sequence(s)
      AA251185, AW576194, BC005926
      Consensus CDS
      CCDS11266.1
      UniProtKB/Swiss-Prot
      B7Z4A7, P34910
      UniProtKB/TrEMBL
      Q9BRW1
      Related
      ENSP00000333779.4, ENST00000330927.5
      Conserved Domains (1) summary
      cl10080
      Location:122208
      RPE65; Retinal pigment epithelial membrane protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      31303770..31314054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791803.1 Reference GRCh38.p14 PATCHES

      Range
      382932..393208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      32249455..32259731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)