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    NYNRIN NYN domain and retroviral integrase containing [ Homo sapiens (human) ]

    Gene ID: 57523, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NYNRINprovided by HGNC
    Official Full Name
    NYN domain and retroviral integrase containingprovided by HGNC
    Primary source
    HGNC:HGNC:20165
    See related
    Ensembl:ENSG00000205978 MIM:620129; AllianceGenome:HGNC:20165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGIN1; KIAA1305
    Summary
    Predicted to enable RNA endonuclease activity and mRNA binding activity. Predicted to be involved in DNA integration; DNA synthesis involved in DNA repair; and DNA-templated DNA replication. Predicted to be located in membrane. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 19.4), endometrium (RPKM 6.6) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NYNRIN in Genome Data Viewer
    Location:
    14q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24399003..24419283)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18597752..18618021)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24868209..24888489)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903291 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5641 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24839191-24840034 Neighboring gene nuclear factor of activated T cells 4 Neighboring gene uncharacterized LOC124903292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8217 Neighboring gene KH and NYN domain containing Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24899891-24900454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24900455-24901016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24901017-24901578 Neighboring gene cerebellin 3 precursor Neighboring gene short chain dehydrogenase/reductase family 39U member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CGIN1: a retroviral contribution to mammalian genomes. Marco A, et al. Mol Biol Evol, 2009 Oct. PMID 19561090
    2. Biological, clinical and population relevance of 95 loci for blood lipids. Teslovich TM, et al. Nature, 2010 Aug 5. PMID 20686565, Free PMC Article
    3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Feb 28. PMID 10718198
    4. Discovery and refinement of loci associated with lipid levels. Willer CJ, et al. Nat Genet, 2013 Nov. PMID 24097068, Free PMC Article
    5. Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets. Mihalič F, et al. Nat Commun, 2023 Sep 13. PMID 37704626, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological, clinical and population relevance of 95 loci for blood lipids.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11811, KIAA1305

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA-DNA hybrid ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA integration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA synthesis involved in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein NYNRIN
    Names
    Cousin of GIN1
    NYN domain and retroviral integrase catalytic domain-containing protein
    protein cousin of GIN1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025081.3 → NP_079357.2  protein NYNRIN

      See identical proteins and their annotated locations for NP_079357.2

      Status: VALIDATED

      Source sequence(s)
      AB037726, AL132800, BC065283
      Consensus CDS
      CCDS45090.1
      UniProtKB/Swiss-Prot
      Q6P153, Q86TR3, Q9HAC4, Q9P2P1
      Related
      ENSP00000371994.3, ENST00000382554.4
      Conserved Domains (2) summary
      pfam11977
      Location:791 → 942
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
      cl14782
      Location:1161 → 1264
      RNase_H_like; Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      24399003..24419283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537016.2 → XP_011535318.1  protein NYNRIN isoform X1

      Conserved Domains (2) summary
      cl14782
      Location:281 → 384
      RNase_H_like; Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8
      cl20439
      Location:2 → 62
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      18597752..18618021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376460.1 → XP_054232435.1  protein NYNRIN isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9P2P1.3 GenPept UniProtKB/Swiss-Prot:Q9P2P1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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