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    PPP6C protein phosphatase 6 catalytic subunit [ Homo sapiens (human) ]

    Gene ID: 5537, updated on 9-Dec-2024

    Summary

    Official Symbol
    PPP6Cprovided by HGNC
    Official Full Name
    protein phosphatase 6 catalytic subunitprovided by HGNC
    Primary source
    HGNC:HGNC:9323
    See related
    Ensembl:ENSG00000119414 MIM:612725; AllianceGenome:HGNC:9323
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP6; PP6C
    Summary
    This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 20.0), fat (RPKM 18.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PPP6C in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (125146573..125189803, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137344915..137388140, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127908852..127952082, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene suppressor of cancer cell invasion Neighboring gene NANOG hESC enhancer GRCh37_chr9:127737373-127737931 Neighboring gene frataxin pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127806191-127806703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127806704-127807217 Neighboring gene uncharacterized LOC124902355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20274 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127951404-127952190 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127952191-127952977 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 2 Neighboring gene uncharacterized LOC105376271 Neighboring gene ribosomal protein SA pseudogene 76

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, protein phosphatase 6, catalytic subunit (PPP6C), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ92648, MGC12249

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in COPII vesicle coating TAS
    Traceable Author Statement
    more info
     
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cGAS/STING signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 6 catalytic subunit
    Names
    serine/threonine protein phosphatase catalytic subunit
    NP_001116827.1
    NP_001116841.1
    NP_002712.1
    XP_011517149.1
    XP_047279522.1
    XP_047279523.1
    XP_047279524.1
    XP_054219214.1
    XP_054219215.1
    XP_054219216.1
    XP_054219217.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123355.2NP_001116827.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform a

      See identical proteins and their annotated locations for NP_001116827.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript; it encodes the longest isoform (a).
      Source sequence(s)
      AA251321, AL445930, BC006990, CB250498, DB037210, DC334216
      Consensus CDS
      CCDS48018.1
      UniProtKB/Swiss-Prot
      O00743
      Related
      ENSP00000392147.1, ENST00000451402.5
      Conserved Domains (1) summary
      cd07415
      Location:5326
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    2. NM_001123369.2NP_001116841.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform c

      See identical proteins and their annotated locations for NP_001116841.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks one coding exon compared to variant 1 and encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AA251321, AL445930, BC006990, CB250498, DC369815
      Consensus CDS
      CCDS48019.1
      UniProtKB/Swiss-Prot
      O00743
      Related
      ENSP00000411744.1, ENST00000415905.5
      Conserved Domains (1) summary
      cd07415
      Location:5267
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    3. NM_002721.5NP_002712.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform b

      See identical proteins and their annotated locations for NP_002712.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site and lacks an exon in the coding region, compared to variant 1; it encodes a shorter isoform (b).
      Source sequence(s)
      AA251321, AL445930, BC006990, CB250498, DB037210
      Consensus CDS
      CCDS6861.1
      UniProtKB/Swiss-Prot
      B2R5V6, B7Z2W9, B7Z5K9, O00743, Q5U0A2, Q9UIC9
      UniProtKB/TrEMBL
      A0A024R861
      Related
      ENSP00000362648.4, ENST00000373547.9
      Conserved Domains (1) summary
      cd07415
      Location:5289
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      125146573..125189803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423566.1XP_047279522.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X1

    2. XM_047423568.1XP_047279524.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X3

    3. XM_011518847.4XP_011517149.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

      Conserved Domains (2) summary
      PTZ00239
      Location:15293
      PTZ00239; serine/threonine protein phosphatase 2A; Provisional
      cd07415
      Location:13277
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain
    4. XM_047423567.1XP_047279523.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      137344915..137388140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363239.1XP_054219214.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X1

    2. XM_054363242.1XP_054219217.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X3

    3. XM_054363240.1XP_054219215.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

    4. XM_054363241.1XP_054219216.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2