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    SCAI suppressor of cancer cell invasion [ Homo sapiens (human) ]

    Gene ID: 286205, updated on 9-Dec-2024

    Summary

    Official Symbol
    SCAIprovided by HGNC
    Official Full Name
    suppressor of cancer cell invasionprovided by HGNC
    Primary source
    HGNC:HGNC:26709
    See related
    Ensembl:ENSG00000173611 MIM:619222; AllianceGenome:HGNC:26709
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NET40; C9orf126
    Summary
    This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in brain (RPKM 4.6), lung (RPKM 2.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SCAI in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (124942608..125143528, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (137140969..137341870, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (127704887..127905807, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127623737-127624360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28994 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127634813-127635313 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127643063-127643616 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127646402-127646543 Neighboring gene actin related protein 2/3 complex subunit 5 like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127662503-127663016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127665639-127666139 Neighboring gene RNA, U4 small nuclear 82, pseudogene Neighboring gene golgin A1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:127681363-127681624 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127702954-127703454 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:127703455-127703955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28998 Neighboring gene NANOG hESC enhancer GRCh37_chr9:127737373-127737931 Neighboring gene frataxin pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:127806191-127806703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:127806704-127807217 Neighboring gene uncharacterized LOC124902355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20274 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 pseudogene 2 Neighboring gene protein phosphatase 6 catalytic subunit Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11758, FLJ36664, MGC120525, MGC120526, MGC120528

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein SCAI
    Names
    suppressor of cancer cell invasion protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016620.1 RefSeqGene

      Range
      5032..205952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144877.3NP_001138349.1  protein SCAI isoform 2

      See identical proteins and their annotated locations for NP_001138349.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AL451125, BC104031, BM873972, DB048788
      Consensus CDS
      CCDS48017.1
      UniProtKB/Swiss-Prot
      Q3SXZ1, Q3SXZ2, Q5T163, Q8N1I4, Q8N9R8
      Related
      ENSP00000336756.6, ENST00000336505.11
      Conserved Domains (1) summary
      pfam12070
      Location:64557
      SCAI; Protein SCAI
    2. NM_173690.5NP_775961.2  protein SCAI isoform 1

      See identical proteins and their annotated locations for NP_775961.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL451125, BC104030, BM873972, DB048788
      Consensus CDS
      CCDS43877.1
      UniProtKB/Swiss-Prot
      Q8N9R8
      Related
      ENSP00000362650.4, ENST00000373549.8
      Conserved Domains (1) summary
      pfam12070
      Location:87580
      SCAI; Protein SCAI

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      124942608..125143528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007061282.1 RNA Sequence

    2. XR_007061281.1 RNA Sequence

    3. XR_007061283.1 RNA Sequence

    4. XR_929768.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      137140969..137341870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008487985.1 RNA Sequence

    2. XR_008487984.1 RNA Sequence

    3. XR_008487987.1 RNA Sequence

    4. XR_008487986.1 RNA Sequence