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    CCDC186 coiled-coil domain containing 186 [ Homo sapiens (human) ]

    Gene ID: 55088, updated on 9-Dec-2024

    Summary

    Official Symbol
    CCDC186provided by HGNC
    Official Full Name
    coiled-coil domain containing 186provided by HGNC
    Primary source
    HGNC:HGNC:24349
    See related
    Ensembl:ENSG00000165813 MIM:619249; AllianceGenome:HGNC:24349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCCP1; CCCP-1; C10orf118; golgin104
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in vesicle cytoskeletal trafficking. Predicted to act upstream of or within insulin secretion involved in cellular response to glucose stimulus and response to bacterium. Predicted to be located in Golgi apparatus. Predicted to be active in trans-Golgi network. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.2), prostate (RPKM 7.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CCDC186 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (114120862..114174220, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (115014500..115067844, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (115880621..115933979, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 709, pseudogene Neighboring gene UBE2V1 pseudogene 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:115933644-115934172 Neighboring gene microRNA 2110 Neighboring gene tudor domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:115998924-115999632 Neighboring gene aurora kinase A pseudogene 2 Neighboring gene von Willebrand factor A domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • FLJ10188, FLJ35301, MGC118918, MGC129699

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle cytoskeletal trafficking IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    coiled-coil domain-containing protein 186
    Names
    CTCL tumor antigen HD-CL-01/L14-2
    CTCL tumor antigen L14-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321829.1NP_001308758.1  coiled-coil domain-containing protein 186 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AI672382, AK024739, AK094498, BC030557, BC100670, BX537964
      Consensus CDS
      CCDS7587.1
      UniProtKB/Swiss-Prot
      Q2M2V6, Q3ZB81, Q6NS91, Q7RTP1, Q7Z3E2, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3
      UniProtKB/TrEMBL
      E7ENY5, Q496Y1
      Related
      ENSP00000498136.1, ENST00000648613.1
      Conserved Domains (1) summary
      cl25732
      Location:208594
      SMC_N; RecF/RecN/SMC N terminal domain
    2. NM_018017.4NP_060487.2  coiled-coil domain-containing protein 186 isoform 1

      See identical proteins and their annotated locations for NP_060487.2

      Status: VALIDATED

      Source sequence(s)
      AI672382, AK024739, AK094498, AL834368, BC030557, BX537964, BX643041
      Consensus CDS
      CCDS7587.1
      UniProtKB/Swiss-Prot
      Q2M2V6, Q3ZB81, Q6NS91, Q7RTP1, Q7Z3E2, Q8N117, Q8N3G3, Q8N6C2, Q9NWA3
      UniProtKB/TrEMBL
      E7ENY5, Q496Y1
      Related
      ENSP00000358293.3, ENST00000369287.8
      Conserved Domains (1) summary
      cl25732
      Location:208594
      SMC_N; RecF/RecN/SMC N terminal domain
    3. NM_153249.1NP_694981.1  coiled-coil domain-containing protein 186 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK092620, BC030557
      Consensus CDS
      CCDS81506.1
      UniProtKB/TrEMBL
      A0A0C4DFU7
      Related
      ENSP00000358291.3, ENST00000369285.7

    RNA

    1. NR_135815.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC022023, AI672382, AK024739, AK094498, BC030557, BC103504, BX537964

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      114120862..114174220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539915.4XP_011538217.1  coiled-coil domain-containing protein 186 isoform X1

      Conserved Domains (1) summary
      cl19219
      Location:247332
      DUF342; Protein of unknown function (DUF342)
    2. XM_011539916.4XP_011538218.1  coiled-coil domain-containing protein 186 isoform X2

      Conserved Domains (1) summary
      cl19219
      Location:323409
      DUF342; Protein of unknown function (DUF342)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      115014500..115067844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366166.1XP_054222141.1  coiled-coil domain-containing protein 186 isoform X1

    2. XM_054366167.1XP_054222142.1  coiled-coil domain-containing protein 186 isoform X2