LNCOC1 lncRNA associated with ovarian cancer 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LNCOC1provided by HGNC
Official Full Name: lncRNA associated with ovarian cancer 1provided by HGNC
Primary source: HGNC:HGNC:53947
See related: Ensembl:ENSG00000253741 AllianceGenome:HGNC:53947
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Lnc-OC1
Expression: Biased expression in testis (RPKM 4.6), brain (RPKM 1.4) and 4 other tissues See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8q24.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (142702252..142726973, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (143845640..143870361, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (143783670..143808391, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Correlation Between Helicobacter pylori Infection and Lnc-OC1 Expression in Gastric Cancer Tissues in an Iranian Population.
Title: The Correlation Between Helicobacter pylori Infection and Lnc-OC1 Expression in Gastric Cancer Tissues in an Iranian Population.
Downregulation of Lnc-OC1 attenuates the pathogenesis of polycystic ovary syndrome.
Title: Downregulation of Lnc-OC1 attenuates the pathogenesis of polycystic ovary syndrome.
rescue experiments demonstrated that the oncogenic function of Lnc-OC1 at least partially depended on suppressing miR-34a and miR-34c. In conclusion, our results suggest that the Lnc-OC1-miR-34a/34c axis may play a pivotal role in ovarian cancer (OC), and may serve as a potential diagnostic biomarker and a powerful therapeutic target for OC
Title: A novel lncRNA, Lnc-OC1, promotes ovarian cancer cell proliferation and migration by sponging miR-34a and miR-34c.

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

Go to the top of the page Help

Markers

RH15611 (e-PCR)
- UniSTS:25354

A009E39 (e-PCR)
- UniSTS:59419

RH98969 (e-PCR)
- UniSTS:84018

RH65649 (e-PCR)
- UniSTS:4661

G32486 (e-PCR)
- UniSTS:117071

LY6K__7345 (e-PCR)
- UniSTS:466287

RH70955 (e-PCR)
- UniSTS:15304

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.