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    MRPS23 mitochondrial ribosomal protein S23 [ Homo sapiens (human) ]

    Gene ID: 51649, updated on 9-Dec-2024

    Summary

    Official Symbol
    MRPS23provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein S23provided by HGNC
    Primary source
    HGNC:HGNC:14509
    See related
    Ensembl:ENSG00000181610 MIM:611985; AllianceGenome:HGNC:14509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    mS23; CGI-138; COXPD46; HSPC329; MRP-S23
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart (RPKM 19.2), prostate (RPKM 17.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MRPS23 in Genome Data Viewer
    Location:
    17q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (57834781..57850044, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (58708009..58723292, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55912142..55927405, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55828159-55828658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55838959-55839579 Neighboring gene coiled-coil domain containing 182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55839580-55840199 Neighboring gene MPRA-validated peak2914 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8751 Neighboring gene RN7SK pseudogene 94 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55887988-55888874 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:55910113-55910624 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:55910625-55911135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55911304-55911804 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55923593-55924200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55927391-55927900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55937722-55938572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55938573-55939422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55939423-55940272 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:55945275-55946474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55951125-55951765 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55951766-55952407 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55953049-55953690 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55953691-55954331 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:55956376-55956928 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55958036-55958588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55958589-55959141 Neighboring gene CUE domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55962626-55963126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55969929-55970670 Neighboring gene Sharpr-MPRA regulatory region 2303 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:55977227-55977897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12452 Neighboring gene uncharacterized LOC107985065 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:55991179-55991679 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:56004573-56005088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12454 Neighboring gene Sharpr-MPRA regulatory region 4150 Neighboring gene Sharpr-MPRA regulatory region 6256 Neighboring gene NANOG hESC enhancer GRCh37_chr17:56029838-56030339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8753 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56043109-56043617 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:56046907-56047067 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8755 Neighboring gene uncharacterized LOC101929185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8756 Neighboring gene vascular endothelial zinc finger 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    small ribosomal subunit protein mS23
    Names
    28S ribosomal protein S23, mitochondrial
    S23mt
    mitochondrial small ribosomal subunit protein mS23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016070.4NP_057154.2  small ribosomal subunit protein mS23

      See identical proteins and their annotated locations for NP_057154.2

      Status: REVIEWED

      Source sequence(s)
      AC015845, AF151896, AW299554, BC000242, BI962985, BX479815
      Consensus CDS
      CCDS11598.1
      UniProtKB/Swiss-Prot
      B2R6V3, Q96Q24, Q9BWH8, Q9P053, Q9Y3D9
      Related
      ENSP00000320184.8, ENST00000313608.13
      Conserved Domains (1) summary
      pfam10484
      Location:2128
      MRP-S23; Mitochondrial ribosomal protein S23

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      57834781..57850044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      58708009..58723292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)