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    SLC5A10 solute carrier family 5 member 10 [ Homo sapiens (human) ]

    Gene ID: 125206, updated on 10-Dec-2024

    Summary

    Official Symbol
    SLC5A10provided by HGNC
    Official Full Name
    solute carrier family 5 member 10provided by HGNC
    Primary source
    HGNC:HGNC:23155
    See related
    Ensembl:ENSG00000154025 MIM:618636; AllianceGenome:HGNC:23155
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGLT5; SGLT-5
    Summary
    This gene is a member of the sodium/glucose transporter family. Members of this family are sodium-dependent transporters and can be divided into two subfamilies based on sequence homology, one that co-transports sugars and the second that transports molecules such as ascorbate, choline, iodide, lipoate, monocaroboxylates, and pantothenate. The protein encoded by this gene has the highest affinity for mannose and has been reported to be most highly expressed in the kidney. This protein may function as a kidney-specific, sodium-dependent mannose and fructose co-transporter. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in kidney (RPKM 27.8), skin (RPKM 6.0) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLC5A10 in Genome Data Viewer
    Location:
    17p11.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (18950676..19022565)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (18897202..18970458)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (18853989..18925878)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11846 Neighboring gene small nucleolar RNA MBII-202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18850561-18851174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18851175-18851788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18864393-18865390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18866439-18866973 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18866974-18867507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18871247-18872190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18874077-18875018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18883844-18884799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18884800-18885754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18885755-18886709 Neighboring gene family with sequence similarity 83 member G Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8282 Neighboring gene Sharpr-MPRA regulatory region 2479 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18917397-18918386 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18934086-18934883 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18935718-18936468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18936469-18937218 Neighboring gene GRB2 related adaptor protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18954567-18955068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18955069-18955568 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:18966649-18967243 Neighboring gene small nucleolar RNA, C/D box 3B-1 Neighboring gene small nucleolar RNA, C/D box 3B-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ25217

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in apical plasma membrane  
    located_in extracellular exosome PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    sodium/mannose cotransporter SLC5A10
    Names
    Na(+)/glucose cotransporter 5
    sodium/glucose cotransporter 5
    solute carrier family 5 (sodium/glucose cotransporter), member 10
    solute carrier family 5 (sodium/sugar cotransporter), member 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042450.4 → NP_001035915.1  sodium/mannose cotransporter SLC5A10 isoform 2

      See identical proteins and their annotated locations for NP_001035915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AA745934, AC003957, BC034380, BP332461, DR003789
      Consensus CDS
      CCDS42275.1
      UniProtKB/Swiss-Prot
      A0PJK1, A8MUC9, B4DPI0, B7WPR4, Q6P5X0, Q8IXM4, Q96LQ1
      Related
      ENSP00000379007.3, ENST00000395645.4
      Conserved Domains (1) summary
      cd11489
      Location:17 → 596
      SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain
    2. NM_001270648.3 → NP_001257577.1  sodium/mannose cotransporter SLC5A10 isoform 3

      See identical proteins and their annotated locations for NP_001257577.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AA745934, AC003957, BC062617, BP332461
      Consensus CDS
      CCDS59278.1
      UniProtKB/Swiss-Prot
      A0PJK1
      Related
      ENSP00000379005.2, ENST00000395643.6
      Conserved Domains (1) summary
      cl00456
      Location:17 → 569
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. NM_001270649.2 → NP_001257578.1  sodium/mannose cotransporter SLC5A10 isoform 4

      See identical proteins and their annotated locations for NP_001257578.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AA745934, AC003957, AK298345, BC062617, BP332461, DR003789
      Consensus CDS
      CCDS59277.1
      UniProtKB/Swiss-Prot
      A0PJK1
      Related
      ENSP00000401875.2, ENST00000417251.6
      Conserved Domains (1) summary
      cl00456
      Location:17 → 560
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. NM_001282417.1 → NP_001269346.1  sodium/mannose cotransporter SLC5A10 isoform 5

      See identical proteins and their annotated locations for NP_001269346.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has many differences in the coding region but maintains the reading frame compared to variant 1. This variant encodes isoform 5, which has a shorter N-terminus and is shorter compared to isoform 1.
      Source sequence(s)
      AA745934, BC034380, BC039868
      Consensus CDS
      CCDS74008.1
      UniProtKB/Swiss-Prot
      A0PJK1
      Related
      ENSP00000324346.6, ENST00000317977.10
      Conserved Domains (1) summary
      cl00456
      Location:1 → 566
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    5. NM_152351.6 → NP_689564.3  sodium/mannose cotransporter SLC5A10 isoform 1

      See identical proteins and their annotated locations for NP_689564.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA745934, AC003957, AK057946, BC034380
      Consensus CDS
      CCDS11201.2
      UniProtKB/Swiss-Prot
      A0PJK1
      Related
      ENSP00000379008.2, ENST00000395647.6
      Conserved Domains (1) summary
      cd11489
      Location:17 → 612
      SLC5sbd_SGLT5; Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      18950676..19022565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024191.3 → XP_016879680.2  sodium/mannose cotransporter SLC5A10 isoform X1

      Conserved Domains (1) summary
      cl00456
      Location:17 → 649
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      18897202..18970458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315079.1 → XP_054171054.1  sodium/mannose cotransporter SLC5A10 isoform X2

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