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    DBP D-box binding PAR bZIP transcription factor [ Homo sapiens (human) ]

    Gene ID: 1628, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DBPprovided by HGNC
    Official Full Name
    D-box binding PAR bZIP transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:2697
    See related
    Ensembl:ENSG00000105516 MIM:124097; AllianceGenome:HGNC:2697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DABP; taxREB302
    Summary
    The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in ovary (RPKM 6.3), spleen (RPKM 6.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DBP in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48630030..48637379, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51624512..51631860, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49133287..49140636, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 83 member E Neighboring gene sperm acrosome associated 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:49117268-49117444 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49117749-49118580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49118581-49119412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49119413-49120243 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:49121076-49121906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14903 Neighboring gene ribosomal protein L18 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10889 Neighboring gene Sharpr-MPRA regulatory region 2382 Neighboring gene sphingosine kinase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49130943-49131443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10893 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14904 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr19:49147372-49148073 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49148074-49148774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:49148775-49149475 Neighboring gene secretory blood group 1, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10897 Neighboring gene carbonic anhydrase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49166921-49167422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:49167423-49167922 Neighboring gene netrin 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. N6-methyladenosine-modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2/YAP axis-regulated Hippo pathway. Miao D, et al. Cancer Commun (Lond), 2023 Apr. PMID 36860124, Free PMC Article
    2. Distribution and circadian expression of dbp in SCN and extra-SCN areas in the mouse brain. Yan L, et al. J Neurosci Res, 2000 Jan 15. PMID 10650888
    3. Genomic structure of the human D-site binding protein (DBP) gene. Shutler G, et al. Genomics, 1996 Jun 15. PMID 8786133
    4. Upregulation of D site of albumin promoter binding protein in the brain of patients with intractable epilepsy. Yuan J, et al. Mol Med Rep, 2015 Apr. PMID 25503293, Free PMC Article
    5. Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I. Nyunoya H, et al. Gene, 1993 Apr 30. PMID 8482542

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N6-methyladenosine-modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2/YAP axis-regulated Hippo pathway.
      Title: N6-methyladenosine-modified DBT alleviates lipid accumulation and inhibits tumor progression in clear cell renal cell carcinoma through the ANXA2/YAP axis-regulated Hippo pathway.
    2. Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
      Title: Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
    3. Expression of clock gene Dbp in omental and mesenteric adipose tissue in patients with type 2 diabetes.
      Title: Expression of clock gene Dbp in omental and mesenteric adipose tissue in patients with type 2 diabetes.
    4. The Association Between VDR and GC Polymorphisms and Lung Cancer Risk: A Systematic Review and Meta-Analysis.
      Title: The Association Between VDR and GC Polymorphisms and Lung Cancer Risk: A Systematic Review and Meta-Analysis.
    5. Vitamin D binding protein and risk of renal cell carcinoma in the prostate, lung, colorectal and ovarian cancer screening trial.
      Title: Vitamin D binding protein and risk of renal cell carcinoma in the prostate, lung, colorectal and ovarian cancer screening trial.
    6. the expression of DBP and MAPK in epilepsy patients was upregulated, suggesting a possible pathogenetic role in IE.
      Title: Upregulation of D site of albumin promoter binding protein in the brain of patients with intractable epilepsy.
    7. Lean individuals exhibited significant (P < 0.05) temporal changes of core clock (PER1, PER2, PER3, CRY2, BMAL1, and DBP) and metabolic (REVERBalpha, RIP140, and PGC1alpha) genes.
      Title: Rhythmic diurnal gene expression in human adipose tissue from individuals who are lean, overweight, and type 2 diabetic.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D site-binding protein
    Names
    D site of albumin promoter (albumin D-box) binding protein
    albumin D box-binding protein
    albumin D-element-binding protein
    tax-responsive enhancer element-binding protein 302

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001352.5 → NP_001343.2  D site-binding protein

      See identical proteins and their annotated locations for NP_001343.2

      Status: REVIEWED

      Source sequence(s)
      AC022154, BC011965, CA425431, DA068934
      Consensus CDS
      CCDS12728.1
      UniProtKB/Swiss-Prot
      A2I2P4, Q10586
      Related
      ENSP00000222122.4, ENST00000222122.10
      Conserved Domains (1) summary
      cd14695
      Location:254 → 313
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      48630030..48637379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      51624512..51631860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10586.1 GenPept UniProtKB/Swiss-Prot:Q10586

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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