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    TRAPPC6B trafficking protein particle complex subunit 6B [ Homo sapiens (human) ]

    Gene ID: 122553, updated on 10-Dec-2024

    Summary

    Official Symbol
    TRAPPC6Bprovided by HGNC
    Official Full Name
    trafficking protein particle complex subunit 6Bprovided by HGNC
    Primary source
    HGNC:HGNC:23066
    See related
    Ensembl:ENSG00000182400 MIM:610397; AllianceGenome:HGNC:23066
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TPC6; NEDMEBA
    Summary
    TRAPPC6B is a component of TRAPP complexes, which are tethering complexes involved in vesicle transport (Kummel et al., 2005 [PubMed 16025134]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in brain (RPKM 16.1), thyroid (RPKM 9.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TRAPPC6B in Genome Data Viewer
    Location:
    14q21.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (39147814..39170333, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (33336495..33359014, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (39617018..39639537, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:39579989-39580506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8285 Neighboring gene peptidylprolyl isomerase A pseudogene 4 Neighboring gene gem nuclear organelle associated protein 2 Neighboring gene ribosomal protein L7a pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:39638995-39639584 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:39640175-39640764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8287 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:39644148-39645347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:39646527-39647027 Neighboring gene PNN antisense RNA 1 Neighboring gene pinin, desmosome associated protein Neighboring gene transmembrane protein 92 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:39672946-39674145

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ17772, FLJ79549

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of TRAPP complex  
    part_of TRAPPII protein complex PubMed 
    is_active_in cis-Golgi network  
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in endoplasmic reticulum  
    is_active_in trans-Golgi network  

    General protein information

    Preferred Names
    trafficking protein particle complex subunit 6B
    Names
    TRAPP complex subunit 6B
    trafficking protein particle complex 6B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079537.2NP_001073005.1  trafficking protein particle complex subunit 6B isoform 1

      See identical proteins and their annotated locations for NP_001073005.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK025437, AL132639, BX161510
      Consensus CDS
      CCDS41947.1
      UniProtKB/Swiss-Prot
      B3KPS2, Q5JPD6, Q86SZ2, Q86U35, Q86X35
      Related
      ENSP00000330289.5, ENST00000330149.10
      Conserved Domains (1) summary
      cd14944
      Location:3156
      TRAPPC6A_Trs33; Trs33 subunit of the TRAPP complex
    2. NM_177452.4NP_803235.1  trafficking protein particle complex subunit 6B isoform 2

      See identical proteins and their annotated locations for NP_803235.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid-coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL132639, BC047328
      Consensus CDS
      CCDS9670.1
      UniProtKB/Swiss-Prot
      Q86SZ2
      Related
      ENSP00000335171.6, ENST00000347691.9
      Conserved Domains (1) summary
      cd14944
      Location:3128
      TRAPPC6A_Trs33; Trs33 subunit of the TRAPP complex

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      39147814..39170333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      33336495..33359014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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