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    FDX1 ferredoxin 1 [ Homo sapiens (human) ]

    Gene ID: 2230, updated on 9-Dec-2024

    Summary

    Official Symbol
    FDX1provided by HGNC
    Official Full Name
    ferredoxin 1provided by HGNC
    Primary source
    HGNC:HGNC:3638
    See related
    Ensembl:ENSG00000137714 MIM:103260; AllianceGenome:HGNC:3638
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADX; FDX; LOH11CR1D
    Summary
    This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011]
    Expression
    Biased expression in adrenal (RPKM 178.6), kidney (RPKM 13.5) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FDX1 in Genome Data Viewer
    Location:
    11q22.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (110429331..110464884)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (110439522..110475104)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (110300672..110335608)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5502 Neighboring gene Sharpr-MPRA regulatory region 14338 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:110233983-110234504 Neighboring gene long intergenic non-protein coding RNA 2732 Neighboring gene uncharacterized LOC107984385 Neighboring gene MPRA-validated peak1468 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5503 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:110435314-110436165 Neighboring gene uncharacterized LOC124902753 Neighboring gene Rho GTPase activating protein 20 Neighboring gene uncharacterized LOC124902754

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables iron ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in P450-containing electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to forskolin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hormone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    adrenodoxin, mitochondrial
    Names
    adrenal ferredoxin
    hepatoredoxin
    mitochondrial adrenodoxin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004109.5NP_004100.1  adrenodoxin, mitochondrial precursor

      See identical proteins and their annotated locations for NP_004100.1

      Status: REVIEWED

      Source sequence(s)
      AA505582, BC010284, CN333249, DB459133
      Consensus CDS
      CCDS8344.1
      UniProtKB/Swiss-Prot
      B0YJ14, P10109, Q53YD6
      Related
      ENSP00000260270.2, ENST00000260270.3
      Conserved Domains (1) summary
      cl00159
      Location:67168
      fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      110429331..110464884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426566.1XP_047282522.1  adrenodoxin, mitochondrial isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      110439522..110475104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368047.1XP_054224022.1  adrenodoxin, mitochondrial isoform X1