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    NCOR1 nuclear receptor corepressor 1 [ Homo sapiens (human) ]

    Gene ID: 9611, updated on 10-Dec-2024

    Summary

    Official Symbol
    NCOR1provided by HGNC
    Official Full Name
    nuclear receptor corepressor 1provided by HGNC
    Primary source
    HGNC:HGNC:7672
    See related
    Ensembl:ENSG00000141027 MIM:600849; AllianceGenome:HGNC:7672
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    N-CoR; TRAC1; N-CoR1; hN-CoR; PPP1R109
    Summary
    This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.9), colon (RPKM 10.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NCOR1 in Genome Data Viewer
    Location:
    17p12-p11.2
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (16029157..16215534, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (15931369..16117845, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (15932471..16118848, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15760104-15761059 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:15761456-15762052 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:15762053-15762649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15785055-15785554 Neighboring gene adenosine A2b receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15831280-15831780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15831781-15832281 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15848447-15849261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:15854153-15854950 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15869033-15869619 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15870206-15870792 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15869620-15870205 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15870793-15871377 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15871628-15872376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15872377-15873123 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:15881867-15882452 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:15882453-15883039 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:15885417-15886106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11746 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8214 Neighboring gene zinc finger SWIM-type containing 7 Neighboring gene MPRA-validated peak2750 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8215 Neighboring gene Sharpr-MPRA regulatory region 10193 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:15947413-15947923 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:15947924-15948433 Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 11 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:15998016-15998870 Neighboring gene ribosomal protein L22 pseudogene 21 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:16016940-16017137 Neighboring gene RNA, U6 small nuclear 314, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16048157-16048665 Neighboring gene RNA, U6 small nuclear 862, pseudogene Neighboring gene small nucleolar RNA, C/D box 163 Neighboring gene RNA, 7SL, cytoplasmic 442, pseudogene Neighboring gene hESC enhancers GRCh37_chr17:16117644-16118560 and GRCh37_chr17:16118561-16119476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11749 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11750 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class L Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:16189057-16190046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:16208527-16209028 Neighboring gene microRNA 1288 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8217 Neighboring gene centromere protein V

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif is identified to have a physical interaction with nuclear receptor corepressor 1 (NCOR1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA1047, MGC104216

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromatin PubMed 
    located_in cytosol  
    part_of histone deacetylase complex PubMed 
    located_in membrane PubMed 
    located_in mitotic spindle PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    part_of transcription repressor complex PubMed 

    General protein information

    Preferred Names
    nuclear receptor corepressor 1
    Names
    protein phosphatase 1, regulatory subunit 109
    thyroid hormone- and retinoic acid receptor-associated corepressor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047111.1 RefSeqGene

      Range
      6213..192590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190438.1 → NP_001177367.1  nuclear receptor corepressor 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AF303586, BC056862
      Consensus CDS
      CCDS54094.1
      UniProtKB/Swiss-Prot
      O75376
      UniProtKB/TrEMBL
      Q6PGR4
      Related
      ENSP00000379189.1, ENST00000395848.5
      Conserved Domains (4) summary
      pfam05887
      Location:596 → 677
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      smart00717
      Location:518 → 563
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:518 → 561
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:41 → 128
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    2. NM_001190440.1 → NP_001177369.1  nuclear receptor corepressor 1 isoform 3

      See identical proteins and their annotated locations for NP_001177369.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AB028970, AC002553, AW015698, BC056862
      Consensus CDS
      CCDS54095.1
      UniProtKB/TrEMBL
      Q7Z516
      Related
      ENSP00000379192.1, ENST00000395851.5
      Conserved Domains (4) summary
      cd00167
      Location:440 → 482
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:627 → 670
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:149 → 238
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      NF033845
      Location:723 → 919
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    3. NM_006311.4 → NP_006302.2  nuclear receptor corepressor 1 isoform 1

      See identical proteins and their annotated locations for NP_006302.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC002553, AF044209, AW015698, BJ995810
      Consensus CDS
      CCDS11175.1
      UniProtKB/Swiss-Prot
      B3DLF8, E9PGV6, O75376, Q86YY0, Q9UPV5, Q9UQ18
      UniProtKB/TrEMBL
      Q7Z516
      Related
      ENSP00000268712.2, ENST00000268712.8
      Conserved Domains (4) summary
      cd00167
      Location:440 → 482
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:627 → 670
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:149 → 238
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      NF033845
      Location:704 → 914
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      16029157..16215534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524086.4 → XP_011522388.1  nuclear receptor corepressor 1 isoform X36

      See identical proteins and their annotated locations for XP_011522388.1

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (4) summary
      cd00167
      Location:440 → 482
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:627 → 670
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:149 → 238
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      NF033845
      Location:723 → 919
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    2. XM_006721604.5 → XP_006721667.1  nuclear receptor corepressor 1 isoform X16

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (4) summary
      cd00167
      Location:440 → 482
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:627 → 670
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:149 → 238
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      NF033845
      Location:723 → 919
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    3. XM_005256872.6 → XP_005256929.1  nuclear receptor corepressor 1 isoform X6

      UniProtKB/TrEMBL
      H0Y459, Q7Z516
      Related
      ENSP00000389839.2, ENST00000436068.2
      Conserved Domains (3) summary
      cd00167
      Location:627 → 670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:683 → 857
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    4. XM_047437141.1 → XP_047293097.1  nuclear receptor corepressor 1 isoform X33

      UniProtKB/TrEMBL
      Q7Z516
    5. XM_047437133.1 → XP_047293089.1  nuclear receptor corepressor 1 isoform X23

      UniProtKB/TrEMBL
      Q7Z516
    6. XM_047437128.1 → XP_047293084.1  nuclear receptor corepressor 1 isoform X15

      UniProtKB/TrEMBL
      Q7Z516
    7. XM_047437122.1 → XP_047293078.1  nuclear receptor corepressor 1 isoform X5

      UniProtKB/TrEMBL
      Q7Z516
    8. XM_005256871.6 → XP_005256928.1  nuclear receptor corepressor 1 isoform X4

      UniProtKB/TrEMBL
      Q7Z516
      Related
      ENST00000704743.1
      Conserved Domains (3) summary
      cd00167
      Location:628 → 671
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:684 → 858
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    9. XM_047437140.1 → XP_047293096.1  nuclear receptor corepressor 1 isoform X32

      UniProtKB/TrEMBL
      Q7Z516
    10. XM_047437134.1 → XP_047293090.1  nuclear receptor corepressor 1 isoform X24

      UniProtKB/TrEMBL
      Q7Z516
    11. XM_047437132.1 → XP_047293088.1  nuclear receptor corepressor 1 isoform X21

      UniProtKB/TrEMBL
      Q7Z516
    12. XM_047437125.1 → XP_047293081.1  nuclear receptor corepressor 1 isoform X10

      UniProtKB/TrEMBL
      Q7Z516
    13. XM_047437144.1 → XP_047293100.1  nuclear receptor corepressor 1 isoform X39

      UniProtKB/TrEMBL
      Q7Z516
    14. XM_047437138.1 → XP_047293094.1  nuclear receptor corepressor 1 isoform X30

      UniProtKB/TrEMBL
      Q7Z516
    15. XM_047437142.1 → XP_047293098.1  nuclear receptor corepressor 1 isoform X35

      UniProtKB/TrEMBL
      Q7Z516
    16. XM_047437127.1 → XP_047293083.1  nuclear receptor corepressor 1 isoform X14

      UniProtKB/TrEMBL
      Q7Z516
    17. XM_047437130.1 → XP_047293086.1  nuclear receptor corepressor 1 isoform X18

      UniProtKB/TrEMBL
      Q7Z516
    18. XM_047437126.1 → XP_047293082.1  nuclear receptor corepressor 1 isoform X12

      UniProtKB/TrEMBL
      Q7Z516
    19. XM_005256868.6 → XP_005256925.1  nuclear receptor corepressor 1 isoform X2

      See identical proteins and their annotated locations for XP_005256925.1

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (3) summary
      cd00167
      Location:636 → 679
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:692 → 866
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    20. XM_017025420.3 → XP_016880909.1  nuclear receptor corepressor 1 isoform X38

      UniProtKB/TrEMBL
      Q7Z516
    21. XM_017025417.3 → XP_016880906.1  nuclear receptor corepressor 1 isoform X20

      UniProtKB/TrEMBL
      Q7Z516
    22. XM_005256873.6 → XP_005256930.1  nuclear receptor corepressor 1 isoform X9

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (3) summary
      smart00717
      Location:637 → 682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637 → 680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    23. XM_047437139.1 → XP_047293095.1  nuclear receptor corepressor 1 isoform X31

      UniProtKB/TrEMBL
      Q7Z516
    24. XM_047437137.1 → XP_047293093.1  nuclear receptor corepressor 1 isoform X29

      UniProtKB/TrEMBL
      Q7Z516
    25. XM_047437143.1 → XP_047293099.1  nuclear receptor corepressor 1 isoform X37

      UniProtKB/TrEMBL
      Q7Z516
    26. XM_017025419.3 → XP_016880908.1  nuclear receptor corepressor 1 isoform X34

      UniProtKB/TrEMBL
      Q7Z516
    27. XM_047437131.1 → XP_047293087.1  nuclear receptor corepressor 1 isoform X19

      UniProtKB/TrEMBL
      Q7Z516
    28. XM_017025415.3 → XP_016880904.1  nuclear receptor corepressor 1 isoform X13

      UniProtKB/TrEMBL
      Q7Z516
    29. XM_047437129.1 → XP_047293085.1  nuclear receptor corepressor 1 isoform X17

      UniProtKB/TrEMBL
      Q7Z516
    30. XM_005256874.6 → XP_005256931.1  nuclear receptor corepressor 1 isoform X11

      UniProtKB/TrEMBL
      A0A994J5B8, Q7Z516
      Related
      ENSP00000516022.1, ENST00000704745.1
      Conserved Domains (4) summary
      smart00717
      Location:637 → 682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637 → 680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688 → 770
      SDA1; SDA1
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    31. XM_047437135.1 → XP_047293091.1  nuclear receptor corepressor 1 isoform X25

      UniProtKB/TrEMBL
      Q7Z516
    32. XM_005256875.5 → XP_005256932.1  nuclear receptor corepressor 1 isoform X22

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (4) summary
      smart00717
      Location:637 → 682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637 → 680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688 → 770
      SDA1; SDA1
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    33. XM_017025418.3 → XP_016880907.1  nuclear receptor corepressor 1 isoform X27

      UniProtKB/TrEMBL
      Q7Z516
    34. XM_047437136.1 → XP_047293092.1  nuclear receptor corepressor 1 isoform X28

      UniProtKB/TrEMBL
      Q7Z516
    35. XM_011524085.4 → XP_011522387.1  nuclear receptor corepressor 1 isoform X26

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (4) summary
      smart00717
      Location:637 → 682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637 → 680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688 → 770
      SDA1; SDA1
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    36. XM_047437124.1 → XP_047293080.1  nuclear receptor corepressor 1 isoform X8

      UniProtKB/TrEMBL
      Q7Z516
    37. XM_011524084.4 → XP_011522386.1  nuclear receptor corepressor 1 isoform X3

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (4) summary
      smart00717
      Location:637 → 682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637 → 680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688 → 770
      SDA1; SDA1
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    38. XM_006721603.5 → XP_006721666.1  nuclear receptor corepressor 1 isoform X7

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (4) summary
      smart00717
      Location:637 → 682
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:637 → 680
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam05285
      Location:688 → 770
      SDA1; SDA1
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
    39. XM_005256866.6 → XP_005256923.1  nuclear receptor corepressor 1 isoform X1

      See identical proteins and their annotated locations for XP_005256923.1

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (4) summary
      cd00167
      Location:449 → 491
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:637 → 680
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:149 → 238
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      NF033845
      Location:733 → 929
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    40. XM_017025409.3 → XP_016880898.1  nuclear receptor corepressor 1 isoform X6

      UniProtKB/TrEMBL
      H0Y459, Q7Z516
      Conserved Domains (3) summary
      cd00167
      Location:627 → 670
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:683 → 857
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    41. XM_017025403.3 → XP_016880892.1  nuclear receptor corepressor 1 isoform X4

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (3) summary
      cd00167
      Location:628 → 671
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:684 → 858
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    42. XM_006721602.5 → XP_006721665.1  nuclear receptor corepressor 1 isoform X2

      See identical proteins and their annotated locations for XP_006721665.1

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (3) summary
      cd00167
      Location:636 → 679
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:692 → 866
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    43. XM_006721601.5 → XP_006721664.1  nuclear receptor corepressor 1 isoform X1

      See identical proteins and their annotated locations for XP_006721664.1

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (4) summary
      cd00167
      Location:449 → 491
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:637 → 680
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:149 → 238
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      NF033845
      Location:733 → 929
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    44. XM_017025401.3 → XP_016880890.1  nuclear receptor corepressor 1 isoform X2

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (3) summary
      cd00167
      Location:636 → 679
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:692 → 866
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    45. XM_017025397.3 → XP_016880886.1  nuclear receptor corepressor 1 isoform X1

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (4) summary
      cd00167
      Location:449 → 491
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:637 → 680
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:149 → 238
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      NF033845
      Location:733 → 929
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    46. XM_047437123.1 → XP_047293079.1  nuclear receptor corepressor 1 isoform X6

      UniProtKB/TrEMBL
      H0Y459, Q7Z516
    47. XM_047437121.1 → XP_047293077.1  nuclear receptor corepressor 1 isoform X4

      UniProtKB/TrEMBL
      Q7Z516
    48. XM_017025400.3 → XP_016880889.1  nuclear receptor corepressor 1 isoform X2

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (3) summary
      cd00167
      Location:636 → 679
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam15784
      Location:150 → 237
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      cl26247
      Location:692 → 866
      DNA_pol3_delta2; DNA polymerase III, delta subunit
    49. XM_017025396.3 → XP_016880885.1  nuclear receptor corepressor 1 isoform X1

      UniProtKB/TrEMBL
      Q7Z516
      Conserved Domains (4) summary
      cd00167
      Location:449 → 491
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:637 → 680
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam15784
      Location:149 → 238
      GPS2_interact; G-protein pathway suppressor 2-interacting domain
      NF033845
      Location:733 → 929
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      15931369..16117845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317954.1 → XP_054173929.1  nuclear receptor corepressor 1 isoform X36

      UniProtKB/TrEMBL
      Q7Z516
    2. XM_054317934.1 → XP_054173909.1  nuclear receptor corepressor 1 isoform X16

      UniProtKB/TrEMBL
      Q7Z516
    3. XM_054317922.1 → XP_054173897.1  nuclear receptor corepressor 1 isoform X6

      UniProtKB/TrEMBL
      H0Y459, Q7Z516
    4. XM_054317951.1 → XP_054173926.1  nuclear receptor corepressor 1 isoform X33

      UniProtKB/TrEMBL
      Q7Z516
    5. XM_054317941.1 → XP_054173916.1  nuclear receptor corepressor 1 isoform X23

      UniProtKB/TrEMBL
      Q7Z516
    6. XM_054317933.1 → XP_054173908.1  nuclear receptor corepressor 1 isoform X15

      UniProtKB/TrEMBL
      Q7Z516
    7. XM_054317921.1 → XP_054173896.1  nuclear receptor corepressor 1 isoform X5

      UniProtKB/TrEMBL
      Q7Z516
    8. XM_054317918.1 → XP_054173893.1  nuclear receptor corepressor 1 isoform X4

      UniProtKB/TrEMBL
      Q7Z516
    9. XM_054317950.1 → XP_054173925.1  nuclear receptor corepressor 1 isoform X32

      UniProtKB/TrEMBL
      Q7Z516
    10. XM_054317942.1 → XP_054173917.1  nuclear receptor corepressor 1 isoform X24

      UniProtKB/TrEMBL
      Q7Z516
    11. XM_054317939.1 → XP_054173914.1  nuclear receptor corepressor 1 isoform X21

      UniProtKB/TrEMBL
      Q7Z516
    12. XM_054317928.1 → XP_054173903.1  nuclear receptor corepressor 1 isoform X10

      UniProtKB/TrEMBL
      Q7Z516
    13. XM_054317957.1 → XP_054173932.1  nuclear receptor corepressor 1 isoform X39

      UniProtKB/TrEMBL
      Q7Z516
    14. XM_054317948.1 → XP_054173923.1  nuclear receptor corepressor 1 isoform X30

      UniProtKB/TrEMBL
      Q7Z516
    15. XM_054317953.1 → XP_054173928.1  nuclear receptor corepressor 1 isoform X35

      UniProtKB/TrEMBL
      Q7Z516
    16. XM_054317932.1 → XP_054173907.1  nuclear receptor corepressor 1 isoform X14

      UniProtKB/TrEMBL
      Q7Z516
    17. XM_054317936.1 → XP_054173911.1  nuclear receptor corepressor 1 isoform X18

      UniProtKB/TrEMBL
      Q7Z516
    18. XM_054317930.1 → XP_054173905.1  nuclear receptor corepressor 1 isoform X12

      UniProtKB/TrEMBL
      Q7Z516
    19. XM_054317913.1 → XP_054173888.1  nuclear receptor corepressor 1 isoform X2

      UniProtKB/TrEMBL
      Q7Z516
    20. XM_054317956.1 → XP_054173931.1  nuclear receptor corepressor 1 isoform X38

      UniProtKB/TrEMBL
      Q7Z516
    21. XM_054317938.1 → XP_054173913.1  nuclear receptor corepressor 1 isoform X20

      UniProtKB/TrEMBL
      Q7Z516
    22. XM_054317927.1 → XP_054173902.1  nuclear receptor corepressor 1 isoform X9

      UniProtKB/TrEMBL
      Q7Z516
    23. XM_054317949.1 → XP_054173924.1  nuclear receptor corepressor 1 isoform X31

      UniProtKB/TrEMBL
      Q7Z516
    24. XM_054317947.1 → XP_054173922.1  nuclear receptor corepressor 1 isoform X29

      UniProtKB/TrEMBL
      Q7Z516
    25. XM_054317955.1 → XP_054173930.1  nuclear receptor corepressor 1 isoform X37

      UniProtKB/TrEMBL
      Q7Z516
    26. XM_054317952.1 → XP_054173927.1  nuclear receptor corepressor 1 isoform X34

      UniProtKB/TrEMBL
      Q7Z516
    27. XM_054317937.1 → XP_054173912.1  nuclear receptor corepressor 1 isoform X19

      UniProtKB/TrEMBL
      Q7Z516
    28. XM_054317931.1 → XP_054173906.1  nuclear receptor corepressor 1 isoform X13

      UniProtKB/TrEMBL
      Q7Z516
    29. XM_054317935.1 → XP_054173910.1  nuclear receptor corepressor 1 isoform X17

      UniProtKB/TrEMBL
      Q7Z516
    30. XM_054317929.1 → XP_054173904.1  nuclear receptor corepressor 1 isoform X11

      UniProtKB/TrEMBL
      A0A994J5B8, Q7Z516
    31. XM_054317943.1 → XP_054173918.1  nuclear receptor corepressor 1 isoform X25

      UniProtKB/TrEMBL
      Q7Z516
    32. XM_054317940.1 → XP_054173915.1  nuclear receptor corepressor 1 isoform X22

      UniProtKB/TrEMBL
      Q7Z516
    33. XM_054317945.1 → XP_054173920.1  nuclear receptor corepressor 1 isoform X27

      UniProtKB/TrEMBL
      Q7Z516
    34. XM_054317946.1 → XP_054173921.1  nuclear receptor corepressor 1 isoform X28

      UniProtKB/TrEMBL
      Q7Z516
    35. XM_054317944.1 → XP_054173919.1  nuclear receptor corepressor 1 isoform X26

      UniProtKB/TrEMBL
      Q7Z516
    36. XM_054317926.1 → XP_054173901.1  nuclear receptor corepressor 1 isoform X8

      UniProtKB/TrEMBL
      Q7Z516
    37. XM_054317914.1 → XP_054173889.1  nuclear receptor corepressor 1 isoform X3

      UniProtKB/TrEMBL
      Q7Z516
    38. XM_054317925.1 → XP_054173900.1  nuclear receptor corepressor 1 isoform X7

      UniProtKB/TrEMBL
      Q7Z516
    39. XM_054317909.1 → XP_054173884.1  nuclear receptor corepressor 1 isoform X1

      UniProtKB/TrEMBL
      Q7Z516
    40. XM_054317923.1 → XP_054173898.1  nuclear receptor corepressor 1 isoform X6

      UniProtKB/TrEMBL
      H0Y459, Q7Z516
    41. XM_054317919.1 → XP_054173894.1  nuclear receptor corepressor 1 isoform X4

      UniProtKB/TrEMBL
      Q7Z516
    42. XM_054317915.1 → XP_054173890.1  nuclear receptor corepressor 1 isoform X2

      UniProtKB/TrEMBL
      Q7Z516
    43. XM_054317910.1 → XP_054173885.1  nuclear receptor corepressor 1 isoform X1

      UniProtKB/TrEMBL
      Q7Z516
    44. XM_054317917.1 → XP_054173892.1  nuclear receptor corepressor 1 isoform X2

      UniProtKB/TrEMBL
      Q7Z516
    45. XM_054317912.1 → XP_054173887.1  nuclear receptor corepressor 1 isoform X1

      UniProtKB/TrEMBL
      Q7Z516
    46. XM_054317924.1 → XP_054173899.1  nuclear receptor corepressor 1 isoform X6

      UniProtKB/TrEMBL
      H0Y459, Q7Z516
    47. XM_054317920.1 → XP_054173895.1  nuclear receptor corepressor 1 isoform X4

      UniProtKB/TrEMBL
      Q7Z516
    48. XM_054317916.1 → XP_054173891.1  nuclear receptor corepressor 1 isoform X2

      UniProtKB/TrEMBL
      Q7Z516
    49. XM_054317911.1 → XP_054173886.1  nuclear receptor corepressor 1 isoform X1

      UniProtKB/TrEMBL
      Q7Z516
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