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    SLC16A7 solute carrier family 16 member 7 [ Homo sapiens (human) ]

    Gene ID: 9194, updated on 10-Dec-2024

    Summary

    Official Symbol
    SLC16A7provided by HGNC
    Official Full Name
    solute carrier family 16 member 7provided by HGNC
    Primary source
    HGNC:HGNC:10928
    See related
    Ensembl:ENSG00000118596 MIM:603654; AllianceGenome:HGNC:10928
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCT2
    Summary
    This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
    Expression
    Broad expression in fat (RPKM 11.7), heart (RPKM 9.2) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLC16A7 in Genome Data Viewer
    Location:
    12q14.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (59596029..59789841)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (59572554..59766418)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (59989810..60183622)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6575 Neighboring gene RNA, U4 small nuclear 20, pseudogene Neighboring gene polyadenylate-binding protein 4-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:60265054-60265568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:60265569-60266081 Neighboring gene uncharacterized LOC124903070

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse  
    is_active_in basolateral plasma membrane  
    located_in basolateral plasma membrane  
    located_in cytosol  
    located_in glutamatergic synapse  
    located_in hippocampal mossy fiber to CA3 synapse  
    located_in nucleoplasm  
    located_in parallel fiber to Purkinje cell synapse  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in postsynaptic density membrane  

    General protein information

    Preferred Names
    monocarboxylate transporter 2
    Names
    solute carrier family 16 (monocarboxylate transporter), member 7
    solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270622.2 → NP_001257551.1  monocarboxylate transporter 2

      See identical proteins and their annotated locations for NP_001257551.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC079905, AC119793, AF058056, BC007463, BC030693, DR000391
      Consensus CDS
      CCDS8961.1
      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
      Related
      ENSP00000449547.1, ENST00000552432.5
      Conserved Domains (1) summary
      TIGR00892
      Location:15 → 458
      2A0113; monocarboxylate transporter 1
    2. NM_001270623.2 → NP_001257552.1  monocarboxylate transporter 2

      See identical proteins and their annotated locations for NP_001257552.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC079905, AC119793, AF049608, AF058056, BC007463, BC030693, DR000391
      Consensus CDS
      CCDS8961.1
      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
      Related
      ENSP00000448071.1, ENST00000547379.6
      Conserved Domains (1) summary
      TIGR00892
      Location:15 → 458
      2A0113; monocarboxylate transporter 1
    3. NM_004731.5 → NP_004722.2  monocarboxylate transporter 2

      See identical proteins and their annotated locations for NP_004722.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC079905, AF058056, BC030693
      Consensus CDS
      CCDS8961.1
      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
      Related
      ENSP00000261187.4, ENST00000261187.8
      Conserved Domains (1) summary
      TIGR00892
      Location:15 → 458
      2A0113; monocarboxylate transporter 1

    RNA

    1. NR_073055.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' end and uses two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC079905, AF058056, AK301725, BC030693
    2. NR_073056.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' end and uses two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC079905, AF058056, AK310281, BC030693

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      59596029..59789841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538989.3 → XP_011537291.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_011537291.1

      UniProtKB/TrEMBL
      F8W0N3
      Conserved Domains (2) summary
      cd06174
      Location:20 → 449
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:15 → 484
      2A0113; monocarboxylate transporter 1
    2. XM_011538992.3 → XP_011537294.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_011537294.1

      UniProtKB/TrEMBL
      F8W0N3
      Conserved Domains (2) summary
      cd06174
      Location:20 → 449
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:15 → 484
      2A0113; monocarboxylate transporter 1
    3. XM_024449276.2 → XP_024305044.1  monocarboxylate transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
      Conserved Domains (1) summary
      TIGR00892
      Location:15 → 458
      2A0113; monocarboxylate transporter 1
    4. XM_011538991.3 → XP_011537293.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_011537293.1

      UniProtKB/TrEMBL
      F8W0N3
      Conserved Domains (2) summary
      cd06174
      Location:20 → 449
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:15 → 484
      2A0113; monocarboxylate transporter 1
    5. XM_005269231.4 → XP_005269288.1  monocarboxylate transporter 2 isoform X2

      See identical proteins and their annotated locations for XP_005269288.1

      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
      Related
      ENSP00000446722.1, ENST00000548610.5
      Conserved Domains (1) summary
      TIGR00892
      Location:15 → 458
      2A0113; monocarboxylate transporter 1
    6. XM_011538990.4 → XP_011537292.1  monocarboxylate transporter 2 isoform X1

      See identical proteins and their annotated locations for XP_011537292.1

      UniProtKB/TrEMBL
      F8W0N3
      Conserved Domains (2) summary
      cd06174
      Location:20 → 449
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:15 → 484
      2A0113; monocarboxylate transporter 1
    7. XM_017020226.3 → XP_016875715.1  monocarboxylate transporter 2 isoform X3

      UniProtKB/TrEMBL
      B4DWX9
      Conserved Domains (1) summary
      cd06174
      Location:1 → 324
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    8. XM_011538995.3 → XP_011537297.1  monocarboxylate transporter 2 isoform X3

      See identical proteins and their annotated locations for XP_011537297.1

      UniProtKB/TrEMBL
      B4DWX9
      Conserved Domains (1) summary
      cd06174
      Location:1 → 324
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    9. XM_047429885.1 → XP_047285841.1  monocarboxylate transporter 2 isoform X3

      UniProtKB/TrEMBL
      B4DWX9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      59572554..59766418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373834.1 → XP_054229809.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/TrEMBL
      F8W0N3
    2. XM_054373837.1 → XP_054229812.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/TrEMBL
      F8W0N3
    3. XM_054373838.1 → XP_054229813.1  monocarboxylate transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
    4. XM_054373839.1 → XP_054229814.1  monocarboxylate transporter 2 isoform X2

      UniProtKB/Swiss-Prot
      O60669, Q8NEM3, Q9UPB3
      UniProtKB/TrEMBL
      F8W0N3
    5. XM_054373836.1 → XP_054229811.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/TrEMBL
      F8W0N3
    6. XM_054373835.1 → XP_054229810.1  monocarboxylate transporter 2 isoform X1

      UniProtKB/TrEMBL
      F8W0N3
    7. XM_054373840.1 → XP_054229815.1  monocarboxylate transporter 2 isoform X3

      UniProtKB/TrEMBL
      B4DWX9
    8. XM_054373841.1 → XP_054229816.1  monocarboxylate transporter 2 isoform X3

      UniProtKB/TrEMBL
      B4DWX9
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