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    CREM cAMP responsive element modulator [ Homo sapiens (human) ]

    Gene ID: 1390, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CREMprovided by HGNC
    Official Full Name
    cAMP responsive element modulatorprovided by HGNC
    Primary source
    HGNC:HGNC:2352
    See related
    Ensembl:ENSG00000095794 MIM:123812; AllianceGenome:HGNC:2352
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ICER; CREM-2; hCREM-2
    Summary
    This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 19.2), adrenal (RPKM 15.7) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CREM in Genome Data Viewer
    Location:
    10p11.21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (35126846..35212958)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (35155414..35241554)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35415774..35501886)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902409 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:35301624-35302194 Neighboring gene cullin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2298 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35379443-35379631 Neighboring gene microRNA 3611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2299 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3263 Neighboring gene RNA, U7 small nuclear 77 pseudogene Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 4 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:35500215-35500774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:35503415-35503916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:35517588-35518088 Neighboring gene long intergenic non-protein coding RNA 2634 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:35536556-35536734 Neighboring gene RNA, U6 small nuclear 794, pseudogene Neighboring gene RNA, U6 small nuclear 1167, pseudogene Neighboring gene cyclin Y

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Variable expression of the transcription factors cAMP response element-binding protein and inducible cAMP early repressor in the normal adrenal cortex and in adrenocortical adenomas and carcinomas. Peri A, et al. J Clin Endocrinol Metab, 2001 Nov. PMID 11701720
    2. The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis. Ohl K, et al. Pediatr Rheumatol Online J, 2018 Jun 20. PMID 29925386, Free PMC Article
    3. CREM activator and repressor isoform expression in human male germ cells. Blöcher S, et al. Int J Androl, 2005 Aug. PMID 16048633
    4. Deoxyribonucleic acid-protein interactions and expression of the human testis-specific lactate dehydrogenase promoter: transcription factor Sp1 plays a major role. Bonny C, et al. Biol Reprod, 1998 Mar. PMID 9510963
    5. Identification and expression of a novel isoform of cAMP response element modulator in the human heart. Müller FU, et al. FASEB J, 1998 Sep. PMID 9737722

    See all (147) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cAMP responsive element modulator (CREM) is a regulator of CD4[+] T cell function.
      Title: The cAMP responsive element modulator (CREM) is a regulator of CD4(+) T cell function.
    2. Methylation Status of cAMP-responsive Element Modulator (CREM) Gene in Infertile Men and Its Association with Sperm Parameters.
      Title: Methylation Status of cAMP-responsive Element Modulator (CREM) Gene in Infertile Men and Its Association with Sperm Parameters.
    3. Cardiac-specific overexpression of CREM-IbDeltaC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation.
      Title: Cardiac-specific overexpression of CREM-IbΔC-X via CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy with spontaneous atrial fibrillation.
    4. Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility.
      Title: Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility.
    5. Differential Expression of CREM/ICER Isoforms Is Associated with the Spontaneous Control of HIV Infection.
      Title: Differential Expression of CREM/ICER Isoforms Is Associated with the Spontaneous Control of HIV Infection.
    6. Decreased SUV39H1 at the promoter region leads to increased CREMalpha and accelerates autoimmune response in CD4[+] T cells from patients with systemic lupus erythematosus.
      Title: Decreased SUV39H1 at the promoter region leads to increased CREMα and accelerates autoimmune response in CD4(+) T cells from patients with systemic lupus erythematosus.
    7. Determining the expression levels of CSF-1 and OCT4, CREM-1, and protamine in testicular biopsies of adult Klinefelter patients: Their possible correlation with spermatogenesis.
      Title: Determining the expression levels of CSF-1 and OCT4, CREM-1, and protamine in testicular biopsies of adult Klinefelter patients: Their possible correlation with spermatogenesis.
    8. Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.
      Title: Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.
    9. Cytokeratin-positive Malignant Tumor in the Abdomen With EWSR1/FUS-CREB Fusion: A Clinicopathologic Study of 8 Cases.
      Title: Cytokeratin-positive Malignant Tumor in the Abdomen With EWSR1/FUS-CREB Fusion: A Clinicopathologic Study of 8 Cases.
    10. Expression of Transcription Factor CREM in Human Tissues.
      Title: Expression of Transcription Factor CREM in Human Tissues.
    Submit: New GeneRIF Correction See all GeneRIFs (83)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Treatment of dopaminergic rat PC12 cells with HIV-1 Tat downregulates the expression of tyrosine hydroxylase (TH) by upregulating the expression of the inducible cAMP early repressor which in turn abrogates the transcription activity of the TH promoter PubMed
    tat Extracellular HIV-1 Tat protein activates the inducible cAMP early repressor (ICER) in both the Jurkat cell line and primary peripheral blood mononuclear cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC17881, MGC41893, MGC111110

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cAMP response element binding protein binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATF4-CREB1 transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-responsive element modulator
    Names
    CREM 2alpha-b protein
    CREM 2beta-a protein
    cAMP response element modulator
    inducible cAMP early repressor ICER

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029065.1 RefSeqGene

      Range
      4974..91081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267562.2 → NP_001254491.1  cAMP-responsive element modulator isoform 23

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23) has an alternate first exon, lacks the exon containing the translation start codon, and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (23) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG573680, BI459432
      UniProtKB/Swiss-Prot
      Q03060
      Conserved Domains (1) summary
      cd14690
      Location:122 → 176
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    2. NM_001267563.2 → NP_001254492.1  cAMP-responsive element modulator isoform 24

      See identical proteins and their annotated locations for NP_001254492.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24) has an alternate first exon and lacks three other exons compared to variant 1. The resulting isoform (24) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL117336, AL157783, BC041810, CB996061
      Conserved Domains (1) summary
      cd14690
      Location:59 → 113
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    3. NM_001267564.2 → NP_001254493.1  cAMP-responsive element modulator isoform 25

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25) uses an alternate first exon in place of the first three exons and contains an alternate in-frame exon compared to variant 1. The resulting isoform (25) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BU193626, CD358637
      Consensus CDS
      CCDS58074.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000379225.3, ENST00000395887.8
      Conserved Domains (1) summary
      cd14690
      Location:225 → 279
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    4. NM_001267565.2 → NP_001254494.1  cAMP-responsive element modulator isoform 26

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (26) has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      BU193626, BU570307, CK300763
      Conserved Domains (2) summary
      pfam02173
      Location:66 → 83
      pKID; pKID domain
      pfam13900
      Location:32 → 67
      GVQW; Putative domain of unknown function

    5. NM_001267566.2 → NP_001254495.1  cAMP-responsive element modulator isoform 27

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (27) has distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      BP370901, BU570307, CK300763
      Conserved Domains (1) summary
      pfam02173
      Location:13 → 50
      pKID; pKID domain

    6. NM_001267567.2 → NP_001254496.1  cAMP-responsive element modulator isoform 28

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28) has an alternate first exon in place of the first five exons compared to variant 1. The resulting isoform (28) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL117336, BC041810, BG720999
      Consensus CDS
      CCDS58075.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000418336.1, ENST00000463314.5
      Conserved Domains (1) summary
      cd14690
      Location:81 → 135
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    7. NM_001267568.2 → NP_001254497.1  cAMP-responsive element modulator isoform 29

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29) has an alternate exon in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (29) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL117336, AW439476, CD639591, CD640977

    8. NM_001267569.2 → NP_001254498.1  cAMP-responsive element modulator isoform 30

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30) has two alternate exons in place of the first six exons and has an alternate last exon compared to variant 1. The resulting isoform (30) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AL117336, AW439476, CD640977

    9. NM_001267570.2 → NP_001254499.1  cAMP-responsive element modulator isoform 31

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31) has two alternate exons in place of the first six exons compared to variant 1. The resulting isoform (31) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK289379, AL117336, BC041810, CD640465
      Consensus CDS
      CCDS58076.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000419810.1, ENST00000468236.5
      Conserved Domains (1) summary
      cd14690
      Location:68 → 122
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    10. NM_001352445.1 → NP_001339374.1  cAMP-responsive element modulator isoform 32

      Status: REVIEWED

      Source sequence(s)
      AK289379, AL117336, AL157783, BC041810, DA823429, HY169431
      Consensus CDS
      CCDS53522.1
      UniProtKB/TrEMBL
      E9PAR2
      Related
      ENSP00000344365.5, ENST00000344351.5
      Conserved Domains (1) summary
      cd14690
      Location:39 → 93
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    11. NM_001352446.1 → NP_001339375.1  cAMP-responsive element modulator isoform 33

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783, BC041810, CD686814, D79104, DA823429, DT220562
      Consensus CDS
      CCDS53523.1
      UniProtKB/TrEMBL
      E9PB41
      Conserved Domains (1) summary
      cd14690
      Location:39 → 93
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    12. NM_001352465.2 → NP_001339394.1  cAMP-responsive element modulator isoform 33

      Status: REVIEWED

      Source sequence(s)
      AA453346, AL117336, AL157783, BC041810
      Consensus CDS
      CCDS53523.1
      UniProtKB/TrEMBL
      E9PB41
      Related
      ENSP00000419018.1, ENST00000474362.5
      Conserved Domains (1) summary
      cd14690
      Location:39 → 93
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    13. NM_001352466.2 → NP_001339395.1  cAMP-responsive element modulator isoform 32

      Status: REVIEWED

      Source sequence(s)
      AL117336, BC041810, CN367927
      Consensus CDS
      CCDS53522.1
      UniProtKB/TrEMBL
      E9PAR2
      Related
      ENSP00000420437.1, ENST00000460270.5
      Conserved Domains (1) summary
      cd14690
      Location:39 → 93
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    14. NM_001352467.2 → NP_001339396.1  cAMP-responsive element modulator isoform 32

      Status: REVIEWED

      Source sequence(s)
      AL117336, BC041810, DR760671
      Consensus CDS
      CCDS53522.1
      UniProtKB/TrEMBL
      E9PAR2
      Conserved Domains (1) summary
      cd14690
      Location:39 → 93
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    15. NM_001394595.1 → NP_001381524.1  cAMP-responsive element modulator isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Consensus CDS
      CCDS7180.1
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Related
      ENSP00000510546.1, ENST00000686585.1
      Conserved Domains (2) summary
      cd14690
      Location:243 → 297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69 → 105
      pKID; pKID domain

    16. NM_001394598.1 → NP_001381527.1  cAMP-responsive element modulator isoform 34

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:239 → 293
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:53 → 89
      pKID; pKID domain

    17. NM_001394600.1 → NP_001381529.1  cAMP-responsive element modulator isoform 35

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:227 → 281
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:53 → 89
      pKID; pKID domain

    18. NM_001394602.1 → NP_001381531.1  cAMP-responsive element modulator isoform 36

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:227 → 281
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:53 → 89
      pKID; pKID domain

    19. NM_001394603.1 → NP_001381532.1  cAMP-responsive element modulator isoform 37

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      pfam02173
      Location:53 → 89
      pKID; pKID domain

    20. NM_001394605.1 → NP_001381534.1  cAMP-responsive element modulator isoform 38

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (2) summary
      cd14690
      Location:188 → 242
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:14 → 50
      pKID; pKID domain

    21. NM_001394608.1 → NP_001381537.1  cAMP-responsive element modulator isoform 39

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Related
      ENSP00000419684.2, ENST00000463960.5
      Conserved Domains (2) summary
      cd14690
      Location:176 → 230
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:53 → 89
      pKID; pKID domain

    22. NM_001394610.1 → NP_001381539.1  cAMP-responsive element modulator isoform 40

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      G5E998
      Conserved Domains (2) summary
      cd14690
      Location:176 → 230
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:53 → 89
      pKID; pKID domain

    23. NM_001394613.1 → NP_001381542.1  cAMP-responsive element modulator isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Consensus CDS
      CCDS7183.1
      UniProtKB/TrEMBL
      G5E998
      Conserved Domains (2) summary
      cd14690
      Location:164 → 218
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:53 → 89
      pKID; pKID domain

    24. NM_001394614.1 → NP_001381543.1  cAMP-responsive element modulator isoform 42

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      C9IYM9
      Conserved Domains (2) summary
      cd14690
      Location:164 → 218
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:53 → 89
      pKID; pKID domain

    25. NM_001394615.1 → NP_001381544.1  cAMP-responsive element modulator isoform 43

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:134 → 188
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    26. NM_001394616.1 → NP_001381545.1  cAMP-responsive element modulator isoform 44

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      C9IYM9
      Conserved Domains (1) summary
      pfam02173
      Location:53 → 89
      pKID; pKID domain

    27. NM_001394617.1 → NP_001381546.1  cAMP-responsive element modulator isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:122 → 176
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    28. NM_001394618.1 → NP_001381547.1  cAMP-responsive element modulator isoform 46

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      Q59FC7
      Conserved Domains (1) summary
      cd14690
      Location:122 → 176
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    29. NM_001394619.1 → NP_001381548.1  cAMP-responsive element modulator isoform 46

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      Q59FC7
      Conserved Domains (1) summary
      cd14690
      Location:122 → 176
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    30. NM_001394620.1 → NP_001381549.1  cAMP-responsive element modulator isoform 47

      Status: REVIEWED

      Source sequence(s)
      AL157783
      UniProtKB/TrEMBL
      A0A0A0MSU8
      Conserved Domains (1) summary
      pfam02173
      Location:69 → 105
      pKID; pKID domain

    31. NM_001394621.1 → NP_001381550.1  cAMP-responsive element modulator isoform 53

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      Q59FC7
      Conserved Domains (1) summary
      cd14690
      Location:93 → 147
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    32. NM_001394622.1 → NP_001381551.1  cAMP-responsive element modulator isoform 48

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783

    33. NM_001394623.1 → NP_001381552.1  cAMP-responsive element modulator isoform 45

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      UniProtKB/TrEMBL
      Q59FC7
      Conserved Domains (1) summary
      cd14690
      Location:81 → 135
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    34. NM_001394625.1 → NP_001381554.1  cAMP-responsive element modulator isoform 49

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:71 → 125
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    35. NM_001394626.1 → NP_001381555.1  cAMP-responsive element modulator isoform 50

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:71 → 125
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    36. NM_001394627.1 → NP_001381556.1  cAMP-responsive element modulator isoform 50

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:71 → 125
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    37. NM_001394628.1 → NP_001381557.1  cAMP-responsive element modulator isoform 51

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:59 → 113
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    38. NM_001394629.1 → NP_001381558.1  cAMP-responsive element modulator isoform 51

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783
      Conserved Domains (1) summary
      cd14690
      Location:59 → 113
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    39. NM_001394630.1 → NP_001381559.1  cAMP-responsive element modulator isoform 52

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783

    40. NM_001394631.1 → NP_001381560.1  cAMP-responsive element modulator isoform 54

      Status: REVIEWED

      Source sequence(s)
      AL157783

    41. NM_001881.4 → NP_001872.3  cAMP-responsive element modulator isoform 2

      See identical proteins and their annotated locations for NP_001872.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. These differences cause translation initiation at a downstream ATG, and result in a shorter isoform (2, also known as b) with a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC017117, BC066342
      Consensus CDS
      CCDS7184.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000363858.3, ENST00000374726.7
      Conserved Domains (1) summary
      pfam02173
      Location:52 → 89
      pKID; pKID domain

    42. NM_181571.3 → NP_853549.1  cAMP-responsive element modulator isoform 1

      See identical proteins and their annotated locations for NP_853549.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). This isoform represents an activator tau2 isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, BI561543
      Consensus CDS
      CCDS7180.1
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Related
      ENSP00000265372.5, ENST00000345491.7
      Conserved Domains (2) summary
      cd14690
      Location:243 → 297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:69 → 105
      pKID; pKID domain

    43. NM_182717.2 → NP_874386.1  cAMP-responsive element modulator isoform 4

      See identical proteins and their annotated locations for NP_874386.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as ICER1 and hCREM 2alpha-a, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (4, also known as d) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, D14826
      Consensus CDS
      CCDS7187.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000420681.1, ENST00000473940.5
      Conserved Domains (1) summary
      cd14690
      Location:64 → 118
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    44. NM_182718.2 → NP_874387.1  cAMP-responsive element modulator isoform 5

      See identical proteins and their annotated locations for NP_874387.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as ICER11 gamma and hCREM 2beta-b, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (5, also known as e) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CN367927, D14826
      Consensus CDS
      CCDS53519.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417460.1, ENST00000488328.5
      Conserved Domains (1) summary
      cd14690
      Location:52 → 106
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    45. NM_182719.2 → NP_874388.1  cAMP-responsive element modulator isoform 6

      See identical proteins and their annotated locations for NP_874388.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as ICER11 and hCREM 2beta-a, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (6, also known as f) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, D14826
      Consensus CDS
      CCDS53517.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417807.1, ENST00000487763.5
      Conserved Domains (1) summary
      cd14690
      Location:64 → 118
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    46. NM_182720.2 → NP_874389.1  cAMP-responsive element modulator isoform 7

      See identical proteins and their annotated locations for NP_874389.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), also known as ICER1 gamma and hCREM 2alpha-b, uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (7, also known as g) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CN367927, D14826
      Consensus CDS
      CCDS53518.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000349387.5, ENST00000356917.9
      Conserved Domains (1) summary
      cd14690
      Location:52 → 106
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    47. NM_182721.2 → NP_874390.1  cAMP-responsive element modulator isoform 8

      See identical proteins and their annotated locations for NP_874390.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (8, also known as h) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AK289379, AL117336, BC041810
      Consensus CDS
      CCDS7188.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417562.1, ENST00000474931.5
      Conserved Domains (1) summary
      cd14690
      Location:56 → 110
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    48. NM_182723.2 → NP_874392.1  cAMP-responsive element modulator isoform 10

      See identical proteins and their annotated locations for NP_874392.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternative downstream promoter, and differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (10, also known as j) with distinct N- and C-termini, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AL117336, BC041810, CD686814
      Consensus CDS
      CCDS53521.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000419075.1, ENST00000488741.5
      Conserved Domains (1) summary
      cd14690
      Location:46 → 100
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    49. NM_182724.2 → NP_874393.1  cAMP-responsive element modulator isoform 11

      See identical proteins and their annotated locations for NP_874393.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (11, also known as k) with a distinct N-terminus, compared to isoform 1. This isoform represents one of the early repressor ICER isoforms.
      Source sequence(s)
      AK289379, AL117336, BC041810
      Consensus CDS
      CCDS53520.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000417327.1, ENST00000490511.1
      Conserved Domains (1) summary
      cd14690
      Location:56 → 110
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    50. NM_182769.3 → NP_877570.1  cAMP-responsive element modulator isoform 13

      See identical proteins and their annotated locations for NP_877570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), also known as CREM theta2-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (13, also known as m) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 2.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264, BP370901
      Consensus CDS
      CCDS7186.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000341875.3, ENST00000342105.7
      Conserved Domains (2) summary
      cd14690
      Location:188 → 242
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:13 → 50
      pKID; pKID domain

    51. NM_182770.3 → NP_877571.1  cAMP-responsive element modulator isoform 14

      See identical proteins and their annotated locations for NP_877571.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), also known as CREM theta2-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (14, also known as n) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 2.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264, BP370901
      UniProtKB/TrEMBL
      C9K092
      Conserved Domains (2) summary
      cd14690
      Location:125 → 179
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:13 → 50
      pKID; pKID domain

    52. NM_182771.2 → NP_877572.1  cAMP-responsive element modulator isoform 15

      See identical proteins and their annotated locations for NP_877572.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), also known as CREM theta1-tau2-beta, uses an alternative downstream promoter, and differs in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter isoform (15, also known as o) with a distinct N-terminus, compared to isoform 1. This isoform represents an activator isoform theta 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264
      Consensus CDS
      CCDS7185.1
      UniProtKB/Swiss-Prot
      Q03060
      Related
      ENSP00000354593.4, ENST00000361599.8
      Conserved Domains (2) summary
      cd14690
      Location:213 → 267
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:38 → 75
      pKID; pKID domain

    53. NM_182772.2 → NP_877573.1  cAMP-responsive element modulator isoform 16

      See identical proteins and their annotated locations for NP_877573.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), also known as CREM theta1-beta, uses an alternative downstream promoter, differs in the 5' UTR and has multiple coding region differences, compared to variant 1. This results in a shorter isoform (16, also known as p) with a distinct N-terminus, compared to isoform 1. This isoform represents a repressor isoform theta 1.
      Source sequence(s)
      AL117336, AY292864, BC041810, BG719264
      UniProtKB/TrEMBL
      J3KR46
      Related
      ENSP00000417165.1, ENST00000484283.5
      Conserved Domains (2) summary
      cd14690
      Location:150 → 204
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:38 → 75
      pKID; pKID domain

    54. NM_183011.2 → NP_898829.1  cAMP-responsive element modulator isoform 21

      See identical proteins and their annotated locations for NP_898829.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), also known as CREM 10, differs in the 5' UTR, 3' UTR, and contains an additional segment in the coding region, compared to variant 1. This results in a shorter isoform (21, also known as u) with a distinct C-terminus, compared to isoform 1. This isoform represents the tau2 activator isoform.
      Source sequence(s)
      AL117336, AL157783
      Consensus CDS
      CCDS7181.1
      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Related
      ENSP00000509489.1, ENST00000685392.1
      Conserved Domains (2) summary
      cd14690
      Location:243 → 297
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68 → 105
      pKID; pKID domain

    55. NM_183012.2 → NP_898830.1  cAMP-responsive element modulator isoform 20

      See identical proteins and their annotated locations for NP_898830.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), also known as CREM 22, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (20, also known as t) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783
      Consensus CDS
      CCDS31181.1
      UniProtKB/TrEMBL
      G5E998
      Related
      ENSP00000363866.3, ENST00000374734.7
      Conserved Domains (2) summary
      cd14690
      Location:180 → 234
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68 → 105
      pKID; pKID domain

    56. NM_183013.3 → NP_898831.1  cAMP-responsive element modulator isoform 19

      See identical proteins and their annotated locations for NP_898831.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), also known as hCREM type1 alpha, differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. This results in a shorter isoform (19, also known as s) with a distinct C-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, BC041810, D14825, DA756152
      Consensus CDS
      CCDS7182.1
      UniProtKB/TrEMBL
      G5E998
      Related
      ENSP00000346804.3, ENST00000354759.7
      Conserved Domains (2) summary
      cd14690
      Location:192 → 246
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68 → 105
      pKID; pKID domain

    57. NM_183060.3 → NP_898883.1  cAMP-responsive element modulator isoform 22

      See identical proteins and their annotated locations for NP_898883.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) differs in the 5' UTR and lacks an in-frame segment of the coding region, compared to variant 1. This variant uses a downstream start codon, compared to variant 1. The resulting isoform (22, also known as v) is shorter and has a shorter N-terminus, compared to isoform 1. This isoform represents the type alpha repressor isoform.
      Source sequence(s)
      AL117336, AL157783, AV707433, BC041810, BI561543
      Consensus CDS
      CCDS7183.1
      UniProtKB/TrEMBL
      G5E998
      Related
      ENSP00000418798.2, ENST00000487132.6
      Conserved Domains (2) summary
      cd14690
      Location:164 → 218
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:53 → 89
      pKID; pKID domain

    RNA

    1. NR_172138.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL157783

    2. NR_172139.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL117336, AL157783

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      35126846..35212958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447824.2 → XP_024303592.1  cAMP-responsive element modulator isoform X2

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:304 → 358
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:117 → 154
      pKID; pKID domain

    2. XM_047424625.1 → XP_047280581.1  cAMP-responsive element modulator isoform X1

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Related
      ENSP00000393538.2, ENST00000429130.7

    3. XM_047424628.1 → XP_047280584.1  cAMP-responsive element modulator isoform X4

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0

    4. XM_047424627.1 → XP_047280583.1  cAMP-responsive element modulator isoform X3

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0

    5. XM_047424630.1 → XP_047280586.1  cAMP-responsive element modulator isoform X8

      UniProtKB/TrEMBL
      G5E998
      Related
      ENSP00000363853.3, ENST00000374721.7

    6. XM_047424629.1 → XP_047280585.1  cAMP-responsive element modulator isoform X7

      UniProtKB/TrEMBL
      G5E998

    7. XM_006717387.4 → XP_006717450.1  cAMP-responsive element modulator isoform X6

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:255 → 309
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68 → 105
      pKID; pKID domain

    8. XM_011519324.3 → XP_011517626.1  cAMP-responsive element modulator isoform X5

      See identical proteins and their annotated locations for XP_011517626.1

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Conserved Domains (2) summary
      cd14690
      Location:255 → 309
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68 → 105
      pKID; pKID domain

    9. XM_006717382.4 → XP_006717445.1  cAMP-responsive element modulator isoform X11

      See identical proteins and their annotated locations for XP_006717445.1

      UniProtKB/TrEMBL
      G5E998
      Conserved Domains (2) summary
      cd14690
      Location:180 → 234
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68 → 105
      pKID; pKID domain

    10. XM_017015731.2 → XP_016871220.1  cAMP-responsive element modulator isoform X14

      Conserved Domains (1) summary
      cd14690
      Location:93 → 147
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    11. XM_047424626.1 → XP_047280582.1  cAMP-responsive element modulator isoform X1

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0

    12. XM_011519325.4 → XP_011517627.1  cAMP-responsive element modulator isoform X5

      See identical proteins and their annotated locations for XP_011517627.1

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0
      Related
      ENSP00000420511.1, ENST00000479070.5
      Conserved Domains (2) summary
      cd14690
      Location:255 → 309
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:68 → 105
      pKID; pKID domain

    13. XM_047424632.1 → XP_047280588.1  cAMP-responsive element modulator isoform X14

    14. XM_047424636.1 → XP_047280592.1  cAMP-responsive element modulator isoform X17

      UniProtKB/TrEMBL
      E9PB41

    15. XM_047424631.1 → XP_047280587.1  cAMP-responsive element modulator isoform X13

    16. XM_011519333.2 → XP_011517635.1  cAMP-responsive element modulator isoform X13

      Conserved Domains (1) summary
      cd14690
      Location:134 → 188
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    17. XM_011519330.3 → XP_011517632.1  cAMP-responsive element modulator isoform X9

      Conserved Domains (2) summary
      cd14690
      Location:200 → 254
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:13 → 50
      pKID; pKID domain

    18. XM_011519331.3 → XP_011517633.1  cAMP-responsive element modulator isoform X10

      Conserved Domains (1) summary
      cd14690
      Location:188 → 242
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    19. XM_011519332.3 → XP_011517634.1  cAMP-responsive element modulator isoform X12

      Conserved Domains (1) summary
      cd14690
      Location:176 → 230
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    20. XM_011519335.3 → XP_011517637.1  cAMP-responsive element modulator isoform X14

      See identical proteins and their annotated locations for XP_011517637.1

      Conserved Domains (1) summary
      cd14690
      Location:93 → 147
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

    21. XM_047424634.1 → XP_047280590.1  cAMP-responsive element modulator isoform X16

    22. XM_047424635.1 → XP_047280591.1  cAMP-responsive element modulator isoform X16

    23. XM_047424637.1 → XP_047280593.1  cAMP-responsive element modulator isoform X17

      UniProtKB/TrEMBL
      E9PB41

    24. XM_047424633.1 → XP_047280589.1  cAMP-responsive element modulator isoform X15

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      35155414..35241554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364838.1 → XP_054220813.1  cAMP-responsive element modulator isoform X2

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0

    2. XM_054364836.1 → XP_054220811.1  cAMP-responsive element modulator isoform X1

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0

    3. XM_054364840.1 → XP_054220815.1  cAMP-responsive element modulator isoform X4

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0

    4. XM_054364839.1 → XP_054220814.1  cAMP-responsive element modulator isoform X3

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0

    5. XM_054364845.1 → XP_054220820.1  cAMP-responsive element modulator isoform X8

      UniProtKB/TrEMBL
      G5E998

    6. XM_054364844.1 → XP_054220819.1  cAMP-responsive element modulator isoform X7

      UniProtKB/TrEMBL
      G5E998

    7. XM_054364843.1 → XP_054220818.1  cAMP-responsive element modulator isoform X6

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0

    8. XM_054364841.1 → XP_054220816.1  cAMP-responsive element modulator isoform X5

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0

    9. XM_054364848.1 → XP_054220823.1  cAMP-responsive element modulator isoform X11

      UniProtKB/TrEMBL
      G5E998

    10. XM_054364854.1 → XP_054220829.1  cAMP-responsive element modulator isoform X14

    11. XM_054364837.1 → XP_054220812.1  cAMP-responsive element modulator isoform X1

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0

    12. XM_054364842.1 → XP_054220817.1  cAMP-responsive element modulator isoform X5

      UniProtKB/Swiss-Prot
      A8K014, A8K3J7, A8K6A1, A8MPQ2, B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, O75519, Q03060, Q14501, Q14503, Q14504, Q14505, Q14506, Q15731, Q16114, Q16116, Q5T9H7, Q5W1A6, Q5W1A7, Q5W1A8, Q5W1A9, Q5W1B0

    13. XM_054364853.1 → XP_054220828.1  cAMP-responsive element modulator isoform X14

    14. XM_054364858.1 → XP_054220833.1  cAMP-responsive element modulator isoform X17

      UniProtKB/TrEMBL
      E9PB41

    15. XM_054364850.1 → XP_054220825.1  cAMP-responsive element modulator isoform X13

    16. XM_054364851.1 → XP_054220826.1  cAMP-responsive element modulator isoform X13

    17. XM_054364846.1 → XP_054220821.1  cAMP-responsive element modulator isoform X9

    18. XM_054364847.1 → XP_054220822.1  cAMP-responsive element modulator isoform X10

    19. XM_054364849.1 → XP_054220824.1  cAMP-responsive element modulator isoform X12

    20. XM_054364852.1 → XP_054220827.1  cAMP-responsive element modulator isoform X14

    21. XM_054364856.1 → XP_054220831.1  cAMP-responsive element modulator isoform X16

    22. XM_054364857.1 → XP_054220832.1  cAMP-responsive element modulator isoform X16

    23. XM_054364859.1 → XP_054220834.1  cAMP-responsive element modulator isoform X17

      UniProtKB/TrEMBL
      E9PB41

    24. XM_054364855.1 → XP_054220830.1  cAMP-responsive element modulator isoform X15

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_182722.1: Suppressed sequence

      Description
      NM_182722.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    2. NM_182725.1: Suppressed sequence

      Description
      NM_182725.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    3. NM_182850.2: Suppressed sequence

      Description
      NM_182850.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    4. NM_182853.2: Suppressed sequence

      Description
      NM_182853.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03060.6 GenPept UniProtKB/Swiss-Prot:Q03060

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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