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    ZCCHC14 zinc finger CCHC-type containing 14 [ Homo sapiens (human) ]

    Gene ID: 23174, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZCCHC14provided by HGNC
    Official Full Name
    zinc finger CCHC-type containing 14provided by HGNC
    Primary source
    HGNC:HGNC:24134
    See related
    Ensembl:ENSG00000140948 MIM:620697; AllianceGenome:HGNC:24134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BDG29; BDG-29
    Summary
    Predicted to enable nucleic acid binding activity; phosphatidylinositol binding activity; and zinc ion binding activity. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 26.9), ovary (RPKM 7.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZCCHC14 in Genome Data Viewer
    Location:
    16q24.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (87406248..87493024, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (93477129..93563941, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87439854..87526630, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene F-box protein 31 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87417185-87417838 Neighboring gene uncharacterized LOC124903747 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87417839-87418490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11321 Neighboring gene tRNA-Met (anticodon CAT) 6-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:87424900-87425858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11322 Neighboring gene microtubule associated protein 1 light chain 3 beta Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:87440788-87441987 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87456781-87457290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87457291-87457798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87458817-87459326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87460343-87460850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87468667-87469584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87486642-87487142 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:87490779-87491978 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87502852-87503437 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:87503438-87504022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87504708-87505665 Neighboring gene nuclear receptor subfamily 3 group C member 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7838 Neighboring gene ZCCHC14 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87552465-87553062 Neighboring gene uncharacterized LOC124903748 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:87573595-87573826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:87575434-87575934

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Plasma concentration of ZCCHC14 contributes to prognostic efficacy in intracerebral hemorrhage patients. Li DL, et al. Eur Rev Med Pharmacol Sci, 2019 Oct. PMID 31646585
    2. Biochemical analysis of the host factor activity of ZCCHC14 in hepatitis A virus replication. Li Y, et al. J Virol, 2024 Apr 16. PMID 38501662, Free PMC Article
    3. Genetic variation at 16q24.2 is associated with small vessel stroke. Traylor M, et al. Ann Neurol, 2017 Mar. PMID 27997041, Free PMC Article
    4. ZCCHC14 regulates proliferation and invasion of non-small cell lung cancer through the MAPK-P38 signalling pathway. Shi X, et al. J Cell Mol Med, 2021 Feb. PMID 33345444, Free PMC Article
    5. A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production. Hyrina A, et al. Cell Rep, 2019 Dec 3. PMID 31801065

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biochemical analysis of the host factor activity of ZCCHC14 in hepatitis A virus replication.
      Title: Biochemical analysis of the host factor activity of ZCCHC14 in hepatitis A virus replication.
    2. circRNA-ZCCHC14 affects the chondrogenic differentiation ability of peripheral blood-derived mesenchymal stem cells by regulating GREM1 through miR-181a.
      Title: circRNA-ZCCHC14 affects the chondrogenic differentiation ability of peripheral blood-derived mesenchymal stem cells by regulating GREM1 through miR-181a.
    3. The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis.
      Title: The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis.
    4. ZCCHC14 regulates proliferation and invasion of non-small cell lung cancer through the MAPK-P38 signalling pathway.
      Title: ZCCHC14 regulates proliferation and invasion of non-small cell lung cancer through the MAPK-P38 signalling pathway.
    5. Plasma concentration of ZCCHC14 contributes to prognostic efficacy in intracerebral hemorrhage patients.
      Title: Plasma concentration of ZCCHC14 contributes to prognostic efficacy in intracerebral hemorrhage patients.
    6. Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing.
      Title: Viral hijacking of the TENT4-ZCCHC14 complex protects viral RNAs via mixed tailing.
    7. A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production.
      Title: A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production.
    8. ZCCHC14 expression is associated with small vessel disease.
      Title: Genetic variation at 16q24.2 is associated with small vessel stroke.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A mega-analysis of genome-wide association studies for major depressive disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger, CCHC domain containing 14 (ZCCHC14) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC14139, MGC126527

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCHC domain-containing protein 14
    Names
    zinc finger, CCHC domain containing 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015144.3 → NP_055959.2  zinc finger CCHC domain-containing protein 14

      Status: VALIDATED

      Source sequence(s)
      AC010531, AC092720, AC105429
      Consensus CDS
      CCDS10961.2
      UniProtKB/TrEMBL
      A0A590UJW6, A0A5F9XIK1
      Related
      ENSP00000499622.1, ENST00000671377.2
      Conserved Domains (3) summary
      cd09558
      Location:431 → 495
      SAM_ZCCH14; SAM domain of ZCCH14 subfamily
      pfam00098
      Location:1045 → 1060
      zf-CCHC; Zinc knuckle
      cl02563
      Location:256 → 339
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      87406248..87493024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005255858.4 → XP_005255915.3  zinc finger CCHC domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A5F9XIK1

    2. XM_017023082.3 → XP_016878571.1  zinc finger CCHC domain-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      H3BS18
      Related
      ENSP00000456499.1, ENST00000561928.1

    RNA

    1. XR_243401.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      93477129..93563941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379872.1 → XP_054235847.1  zinc finger CCHC domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A5F9XIK1

    2. XM_054379873.1 → XP_054235848.1  zinc finger CCHC domain-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      H3BS18

    RNA

    1. XR_008489065.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WYQ9.1 GenPept UniProtKB/Swiss-Prot:Q8WYQ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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