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    SLC4A1AP solute carrier family 4 member 1 adaptor protein [ Homo sapiens (human) ]

    Gene ID: 22950, updated on 10-Dec-2024

    Summary

    Official Symbol
    SLC4A1APprovided by HGNC
    Official Full Name
    solute carrier family 4 member 1 adaptor proteinprovided by HGNC
    Primary source
    HGNC:HGNC:13813
    See related
    Ensembl:ENSG00000163798 MIM:602655; AllianceGenome:HGNC:13813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HLC3
    Summary
    Predicted to enable mRNA binding activity. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 21.2), brain (RPKM 14.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SLC4A1AP in Genome Data Viewer
    Location:
    2p23.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27663889..27694969)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27706977..27738031)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27886756..27917836)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene GPN-loop GTPase 1 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene SPT7 like, STAGA complex subunit gamma Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27875474-27876673 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27904532-27905731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11303 Neighboring gene long intergenic non-protein coding RNA 1460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27938889-27939403 Neighboring gene uncharacterized LOC105374378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27939404-27939917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11305

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    A comprehensive genetic association study of Alzheimer disease in African Americans.
    EBI GWAS Catalog
    Genetic variants associated with breast size also influence breast cancer risk.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10624, FLJ41004, MGC120646, MGC120648

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    kanadaptin
    Names
    HLC-3
    human lung cancer oncogene 3 protein
    kidney anion exchanger adapter protein
    kidney anion exchanger adaptor protein
    lung cancer oncogene 3
    solute carrier family 4 (anion exchanger), member 1, adapter protein
    solute carrier family 4 (anion exchanger), member 1, adaptor protein
    solute carrier family 4 anion exchanger member 1 adapter protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018158.3NP_060628.3  kanadaptin

      Status: VALIDATED

      Source sequence(s)
      AC074091
      Consensus CDS
      CCDS33166.2
      UniProtKB/Swiss-Prot
      A0A087X0M4, A6NJ39, Q4KMT1, Q4KMX0, Q7Z5Q9, Q9BWU0, Q9NVN2
      UniProtKB/TrEMBL
      A0A8Q3WLG9
      Related
      ENSP00000323837.7, ENST00000326019.11
      Conserved Domains (4) summary
      PLN02939
      Location:423536
      PLN02939; transferase, transferring glycosyl groups
      PHA03247
      Location:9112
      PHA03247; large tegument protein UL36; Provisional
      cd00060
      Location:113221
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd19856
      Location:309391
      DSRM_Kanadaptin; double-stranded RNA binding motif of Kanadaptin and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      27663889..27694969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      27706977..27738031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)