Nxf2 nuclear RNA export factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nxf2provided by MGI
Official Full Name: nuclear RNA export factor 2provided by MGI
Primary source: MGI:MGI:1933192
See related: Ensembl:ENSMUSG00000009941 AllianceGenome:MGI:1933192
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nxf-b; 4930455N06Rik
Summary: Enables mRNA binding activity. Acts upstream of or within poly(A)+ mRNA export from nucleus. Located in nuclear envelope. Is expressed in central nervous system; sensory organ; and testis. Orthologous to several human genes including NXF2 (nuclear RNA export factor 2) and NXF2B (nuclear RNA export factor 2B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 2.2), CNS E11.5 (RPKM 0.2) and 1 other tissue See more
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Genomic context

Location:: X F1; X 56.31 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (133845275..133865503, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (134944526..134964754, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These studies demonstrate that Nxf2 plays a dual function in spermatogenesis: regulation of meiosis and maintenance of spermatogonial stem cells.
Title: Inactivation of Nxf2 causes defects in male meiosis and age-dependent depletion of spermatogonia.
Results suggest that NXF2, a nucleo-cytoplasmic mRNA transporter, plays additional roles in the cytoplasmic localization of mRNAs through interactions with cytoplasmic motor proteins.
Title: NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins.
FMRP and Nxf2 associate with and destabilize Nxf1 mRNA in neuronal cells.
Title: Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells.
Exhibits mRNA export activity similar to that of Tip-associated protein/NXF1.
Title: Nuclear export factor family protein participates in cytoplasmic mRNA trafficking.
The NXF2 protein is found in the nucleus, the nuclear envelope and cytoplasm, and is an active mRNA export receptor.
Title: Identification and characterization of the mouse nuclear export factor (Nxf) family members.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nxf2 (e-PCR), detects polymorphism
- UniSTS:479015

px-31c10 (e-PCR)
- UniSTS:258371

G65204 (e-PCR)
- UniSTS:225866

G65780 (e-PCR)
- UniSTS:225903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within RNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within poly(A)+ mRNA export from nucleus	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of nuclear RNA export factor complex	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear RNA export factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289735.1 → NP_001276664.1 nuclear RNA export factor 5 isoform 1

See identical proteins and their annotated locations for NP_001276664.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AB178900, AK015471

Consensus CDS

CCDS72433.1

UniProtKB/TrEMBL

Q4ZGD8, Q99NI0

Related

ENSMUSP00000010085.4, ENSMUST00000010085.4

Conserved Domains (5) summary

smart00804
Location:630 → 691

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:230 → 272

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:123 → 204

Tap-RNA_bind; Tap, RNA-binding

pfam12799
Location:271 → 317

LRR_4; Leucine Rich repeats (2 copies)

cl09109
Location:451 → 606

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
NM_001289736.1 → NP_001276665.1 nuclear RNA export factor 5 isoform 3

See identical proteins and their annotated locations for NP_001276665.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 3) is shorter, compared to isoform 1.

Source sequence(s)

AF285575, AK015471, AL672063

Consensus CDS

CCDS81173.1

UniProtKB/TrEMBL

Q8R499, Q99NI0

Related

ENSMUSP00000108812.2, ENSMUST00000113187.8

Conserved Domains (5) summary

smart00804
Location:610 → 671

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:216 → 258

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:109 → 190

Tap-RNA_bind; Tap, RNA-binding

pfam12799
Location:257 → 303

LRR_4; Leucine Rich repeats (2 copies)

cl09109
Location:437 → 586

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
NM_031259.2 → NP_112549.1 nuclear RNA export factor 5 isoform 2

See identical proteins and their annotated locations for NP_112549.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AF285575, AK015471

Consensus CDS

CCDS41125.1

UniProtKB/TrEMBL

Q99MW6, Q99NI0

Related

ENSMUSP00000108814.2, ENSMUST00000113189.8

Conserved Domains (5) summary

smart00804
Location:624 → 685

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:230 → 272

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:123 → 204

Tap-RNA_bind; Tap, RNA-binding

pfam12799
Location:271 → 317

LRR_4; Leucine Rich repeats (2 copies)

cl09109
Location:451 → 600

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

133845275..133865503 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247765.3 → XP_011246067.1 nuclear RNA export factor 5 isoform X1

Related

ENSMUST00000143059.2

Conserved Domains (3) summary

smart00804
Location:416 → 477

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:16 → 58

LRR_NTF; leucine-rich repeat [structural motif]

cl09109
Location:237 → 392

NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...