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    ZNF131 zinc finger protein 131 [ Homo sapiens (human) ]

    Gene ID: 7690, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF131provided by HGNC
    Official Full Name
    zinc finger protein 131provided by HGNC
    Primary source
    HGNC:HGNC:12915
    See related
    Ensembl:ENSG00000172262 MIM:604073; AllianceGenome:HGNC:12915
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZBTB35; pHZ-10
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 10.2), bone marrow (RPKM 5.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF131 in Genome Data Viewer
    Location:
    5p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (43120914..43176324)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (43373818..43429219)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43121016..43176426)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ANXA2R overlapping transcript 1 Neighboring gene uncharacterized LOC100132356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22532 Neighboring gene uncharacterized LOC100506639 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43073915-43074416 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43074417-43074916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:43078210-43078763 Neighboring gene uncharacterized LOC124900972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15990 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43121535-43122103 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:43122104-43122671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15992 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43192643-43193352 Neighboring gene spermine synthase pseudogene Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene tubulin alpha pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. Han X, et al. BMC Genomics, 2008 Oct 11. PMID 18847501, Free PMC Article
    2. The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus. Trappe R, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163020
    3. Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor α homo-dimerization. Oh Y, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23159625
    4. ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5. Ding Y, et al. Oncotarget, 2017 Jul 25. PMID 28596487, Free PMC Article
    5. Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling. Oh Y, et al. J Biol Chem, 2012 May 18. PMID 22467880, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
      Title: YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
    2. Knockdown circZNF131 Inhibits Cell Progression and Glycolysis in Gastric Cancer Through miR-186-5p/PFKFB2 Axis.
      Title: Knockdown circZNF131 Inhibits Cell Progression and Glycolysis in Gastric Cancer Through miR-186-5p/PFKFB2 Axis.
    3. The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
      Title: The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
    4. Our results suggest that GSCs differentially rely on ZNF131-dependent expression of HAUS5 as well as the Augmin/HAUS complex activity to maintain the integrity of centrosome function and viability.
      Title: ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5.
    5. identify a novel substoichiometric interactor of the complex, transcription factor ZNF131, which recruits EMSY to a large number of active, H3K4me3 marked promoters.
      Title: Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.
    6. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131
      Title: UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131.
    7. these data suggest that ZNF131 inhibits estrogen signaling by acting as an ERalpha-co-repressor.
      Title: Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor α homo-dimerization.
    8. SUMOylation is a novel regulator of ZNF131 action in estrogen signaling and breast cancer cell proliferation.
      Title: Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling.
    9. Interaction between ZNF131 and ERalpha interrupts or prevents ERalpha binding to the estrogen response element. ZNF131 also suppresses the expression of TFF1.
      Title: High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling.
    10. The mechanism of Znf131 nuclear localization, is reported.
      Title: Nuclear trafficking of the POZ-ZF protein Znf131.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 131
    Names
    zinc finger and BTB domain containing 35
    zinc finger protein 131 (clone pHZ-10)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297548.3 → NP_001284477.1  zinc finger protein 131 isoform 1

      See identical proteins and their annotated locations for NP_001284477.1

      Status: VALIDATED

      Source sequence(s)
      AC106800
      Consensus CDS
      CCDS78005.1
      UniProtKB/Swiss-Prot
      B4DRL3, P52739, Q6PIF0
      UniProtKB/TrEMBL
      B3KQ42
      Related
      ENSP00000426504.1, ENST00000509156.5
      Conserved Domains (6) summary
      smart00225
      Location:35 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001330704.2 → NP_001317633.1  zinc finger protein 131 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC106800

    3. NM_001330705.1 → NP_001317634.1  zinc finger protein 131 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC106800

    4. NM_001330706.2 → NP_001317635.1  zinc finger protein 131 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC106800
      Consensus CDS
      CCDS43313.1
      UniProtKB/TrEMBL
      B3KQ42
      Conserved Domains (4) summary
      sd00017
      Location:256 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:388 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:308 → 333
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001330707.2 → NP_001317636.1  zinc finger protein 131 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC106800
      Consensus CDS
      CCDS78005.1
      UniProtKB/Swiss-Prot
      B4DRL3, P52739, Q6PIF0
      UniProtKB/TrEMBL
      B3KQ42
      Related
      ENSP00000507111.1, ENST00000682664.1
      Conserved Domains (6) summary
      smart00225
      Location:35 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    6. NM_001330708.2 → NP_001317637.1  zinc finger protein 131 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC106800
      Consensus CDS
      CCDS78005.1
      UniProtKB/Swiss-Prot
      B4DRL3, P52739, Q6PIF0
      UniProtKB/TrEMBL
      B3KQ42
      Conserved Domains (6) summary
      smart00225
      Location:35 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    7. NM_001330709.2 → NP_001317638.1  zinc finger protein 131 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC106800

    8. NM_001330710.2 → NP_001317639.1  zinc finger protein 131 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC106800

    9. NM_001330711.2 → NP_001317640.1  zinc finger protein 131 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC106800
      Consensus CDS
      CCDS43313.1
      UniProtKB/TrEMBL
      B3KQ42
      Conserved Domains (4) summary
      sd00017
      Location:256 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:388 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:308 → 333
      zf-H2C2_2; Zinc-finger double domain

    10. NM_001330712.2 → NP_001317641.1  zinc finger protein 131 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC106800
      Consensus CDS
      CCDS78005.1
      UniProtKB/Swiss-Prot
      B4DRL3, P52739, Q6PIF0
      UniProtKB/TrEMBL
      B3KQ42
      Conserved Domains (6) summary
      smart00225
      Location:35 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    11. NM_001330713.2 → NP_001317642.1  zinc finger protein 131 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC106800
      Consensus CDS
      CCDS43313.1
      UniProtKB/TrEMBL
      B3KQ42
      Related
      ENSP00000423945.1, ENST00000505606.6
      Conserved Domains (4) summary
      sd00017
      Location:256 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:388 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:308 → 333
      zf-H2C2_2; Zinc-finger double domain

    12. NM_001330714.2 → NP_001317643.1  zinc finger protein 131 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC106800
      Consensus CDS
      CCDS78005.1
      UniProtKB/Swiss-Prot
      B4DRL3, P52739, Q6PIF0
      UniProtKB/TrEMBL
      B3KQ42
      Conserved Domains (6) summary
      smart00225
      Location:35 → 122
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:262 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 311
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:422 → 439
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:24 → 122
      BTB; BTB/POZ domain
      pfam13465
      Location:342 → 367
      zf-H2C2_2; Zinc-finger double domain

    13. NM_001330715.2 → NP_001317644.1  zinc finger protein 131 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC106800
      Consensus CDS
      CCDS43313.1
      UniProtKB/TrEMBL
      B3KQ42
      Conserved Domains (4) summary
      sd00017
      Location:256 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:388 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:308 → 333
      zf-H2C2_2; Zinc-finger double domain

    14. NM_001330716.2 → NP_001317645.1  zinc finger protein 131 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC106800
      UniProtKB/TrEMBL
      B3KQ42

    15. NM_001330717.2 → NP_001317646.1  zinc finger protein 131 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC106800
      UniProtKB/TrEMBL
      B3KQ42
      Conserved Domains (4) summary
      COG5048
      Location:167 → 331
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:177 → 198
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:309 → 326
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:229 → 254
      zf-H2C2_2; Zinc-finger double domain

    16. NM_001388319.1 → NP_001375248.1  zinc finger protein 131 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC106800
      Consensus CDS
      CCDS43313.1
      UniProtKB/TrEMBL
      B3KQ42
      Related
      ENSP00000421246.1, ENST00000509634.5
      Conserved Domains (4) summary
      sd00017
      Location:256 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:388 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:308 → 333
      zf-H2C2_2; Zinc-finger double domain

    17. NM_003432.4 → NP_003423.1  zinc finger protein 131 isoform 2

      See identical proteins and their annotated locations for NP_003423.1

      Status: VALIDATED

      Source sequence(s)
      AC106800
      Consensus CDS
      CCDS43313.1
      UniProtKB/TrEMBL
      B3KQ42
      Related
      ENSP00000305804.4, ENST00000306938.8
      Conserved Domains (4) summary
      sd00017
      Location:256 → 277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:388 → 405
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18221
      Location:16 → 128
      BTB_POZ_ZBTB35_ZNF131; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131)
      pfam13465
      Location:308 → 333
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      43120914..43176324
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      43373818..43429219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52739.2 GenPept UniProtKB/Swiss-Prot:P52739

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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