Srgap2 SLIT-ROBO Rho GTPase activating protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srgap2provided by MGI
Official Full Name: SLIT-ROBO Rho GTPase activating protein 2provided by MGI
Primary source: MGI:MGI:109605
See related: Ensembl:ENSMUSG00000026425 AllianceGenome:MGI:109605
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FBP2; Fnbp2; srGAP3; 9930124L22Rik
Summary: Enables GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Involved in several processes, including filopodium assembly; nervous system development; and positive regulation of GTPase activity. Located in cytosol; phagocytic vesicle; and postsynaptic membrane. Is active in dendritic spine; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; and sensory organ. Orthologous to several human genes including SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 9.6), CNS E18 (RPKM 8.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 56.93 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (131212989..131455269, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (131285251..131527531, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rac1 Inhibition Via Srgap2 Restrains Inflammatory Osteoclastogenesis and Limits the Clastokine, SLIT3.
Title: Rac1 Inhibition Via Srgap2 Restrains Inflammatory Osteoclastogenesis and Limits the Clastokine, SLIT3.
Results show that the effects of Srgap2 expression modulation in the murine OS cell lines support the hypothesis that SRGAP2 may have a role as a suppressor of metastases in osteosarcoma.
Title: Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma.
SRGAP2a protects podocytes in diabetic nephropathy by suppressing podocyte migration.
Title: Dissection of Glomerular Transcriptional Profile in Patients With Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function.
The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.
Title: The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.
Study reports that srGAP2 negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains.
Title: The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis.
Data show that srGAP2 is expressed in zones of neuronal differentiation in many different tissues of the central nervous system.
Title: Dynamic expression of the Slit-Robo GTPase activating protein genes during development of the murine nervous system.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130018 (e-PCR)
- UniSTS:213306

AI448945 (e-PCR)
- UniSTS:165098

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament severing	ISS Inferred from Sequence or Structural Similarity more info
involved_in dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in inhibitory synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine head	ISO Inferred from Sequence Orthology more info
located_in dendritic spine head	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SLIT-ROBO Rho GTPase-activating protein 2

Names: FBP-27; formin binding protein 2; formin-binding protein 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081011.2 → NP_001074480.2 SLIT-ROBO Rho GTPase-activating protein 2

See identical proteins and their annotated locations for NP_001074480.2

Status: VALIDATED

Source sequence(s)

AC165436, AK084412, BC030457, BY779945, CF164437

Consensus CDS

CCDS48355.1

UniProtKB/Swiss-Prot

B2RY13, Q3V1V8, Q61054, Q91Z67

UniProtKB/TrEMBL

A0A2X0SZ45

Related

ENSMUSP00000095195.3, ENSMUST00000097588.9

Conserved Domains (3) summary

cd07682
Location:26 → 289

F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2

cd11955
Location:732 → 784

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:487 → 674

RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

131212989..131455269 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160225.1 → XP_036016118.1 SLIT-ROBO Rho GTPase-activating protein 2 isoform X1

UniProtKB/TrEMBL

A0A087WNM1

Related

ENSMUSP00000139405.2, ENSMUST00000186543.7

Conserved Domains (3) summary

cd11955
Location:732 → 784

SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3

cd04383
Location:487 → 674

RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

cl12013
Location:26 → 289

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

XR_001781100.2 RNA Sequence
XR_004939453.1 RNA Sequence
XR_001781103.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_019520.1: Suppressed sequence

Description

NM_019520.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.