Brinp1 bone morphogenic protein/retinoic acid inducible neural specific 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brinp1provided by MGI
Official Full Name: bone morphogenic protein/retinoic acid inducible neural specific 1provided by MGI
Primary source: MGI:MGI:1928478
See related: Ensembl:ENSMUSG00000028351 AllianceGenome:MGI:1928478
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dbc1; BRINP; Fam5a; Dbccr1
Summary: Involved in cellular response to retinoic acid; central nervous system development; and negative regulation of mitotic cell cycle. Acts upstream of or within several processes, including behavioral fear response; maternal behavior; and protein stabilization. Is active in glutamatergic synapse. Is expressed in central nervous system; dorsal root ganglion; submandibular gland primordium; and urogenital sinus. Used to study attention deficit hyperactivity disorder and autism spectrum disorder. Orthologous to human BRINP1 (BMP/retinoic acid inducible neural specific 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 28.4), frontal lobe adult (RPKM 23.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C1; 4 35.03 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (68679609..68872634, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (68761372..68954397, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The numbers of parvalbumin and somatostatin expressing neurons in the medial prefrontal cortex of BRINP1-knockout mice, were fewer compared to neurons in medial prefrontal cortex of wild-type mice.
Title: Decreased parvalbumin and somatostatin neurons in medial prefrontal cortex in BRINP1-KO mice.
Brinp1 plays an important role in normal brain development and function by influencing neuronal distribution within the cortex.
Title: Brinp1(-/-) mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density.
DBC1 loss results in less p53 protein in vitro and in vivo.
Title: DBC1 functions as a tumor suppressor by regulating p53 stability.
inhibits B cell function by selectively suppressing the transcriptional activity of alternative NF-kappaB pathway upon CD40 stimulation
Title: DBC1 is a suppressor of B cell activation by negatively regulating alternative NF-κB transcriptional activity.
Absence of BRINP1 causes deregulation of neurogenesis and impairments of neuronal differentiation in adult hippocampal circuitry.
Title: Absence of BRINP1 in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders.
Based on these results, the physiological roles of induced BRINP genes in the cell-cycle suppression of terminally differentiated post-mitotic neurons are discussed.
Title: Analysis of the expression and function of BRINP family genes during neuronal differentiation in mouse embryonic stem cell-derived neural stem cells.
The authors show that retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) in cooperation with Toll-like receptor (TLR) 9 is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV).
Title: Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production.
From these results, the physiological roles of the activity-dependent induction of BRINP1-mRNA are discussed.
Title: Activity-dependent regulation of BRINP family genes.
Data show that neuron-restrictive silencing factor (NRSF) plays a role in the neural-selective expression of BMP/RA-inducible neural-specific protein 1.
Title: Molecular mechanisms regulating cell type specific expression of BMP/RA Inducible Neural-specific Protein-1 that suppresses cell cycle progression: roles of NRSF/REST and DNA methylation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Mit346 (e-PCR), detects polymorphism
- UniSTS:130140

D5Got124 (e-PCR)
- UniSTS:112313

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to retinoic acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system neuron development	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maternal behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteasomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vocalization behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: BMP/retinoic acid-inducible neural-specific protein 1

Names: BMP/retinoic acid-inducible neural-specific protein (BRINP); deleted in bladder cancer chromosome region candidate 1; deleted in bladder cancer protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.