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    Trem3 triggering receptor expressed on myeloid cells 3 [ Mus musculus (house mouse) ]

    Gene ID: 58218, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trem3provided by MGI
    Official Full Name
    triggering receptor expressed on myeloid cells 3provided by MGI
    Primary source
    MGI:MGI:1930003
    See related
    Ensembl:ENSMUSG00000041754 AllianceGenome:MGI:1930003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TREM-3
    Summary
    The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and is thought to function as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein has been reported to associate with the adaptor protein Dap-12 to form a receptor signaling complex that activates myeloid cells. [provided by RefSeq, Jan 2013]
    Expression
    Biased expression in liver E18 (RPKM 5.6), liver E14 (RPKM 1.2) and 3 other tissues See more
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    Genomic context

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    See Trem3 in Genome Data Viewer
    Location:
    17 C; 17 23.99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48554707..48565876)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48247677..48258848)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530064D06 gene Neighboring gene STARR-seq mESC enhancer starr_42746 Neighboring gene STARR-seq mESC enhancer starr_42747 Neighboring gene predicted gene, 52308 Neighboring gene triggering receptor expressed on myeloid cells 1 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E9957 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48439578-48439845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48440299-48440452 Neighboring gene triggering receptor expressed on myeloid cells-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Periodontal inflammation and bone loss in aged mice. Liang S, et al. J Periodontal Res, 2010 Aug. PMID 20337897, Free PMC Article
    2. Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia. Chen LC, et al. Exp Mol Pathol, 2008 Apr. PMID 18222421, Free PMC Article
    3. Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice. McQueen BE, et al. Infect Immun, 2021 Sep 16. PMID 34125599, Free PMC Article
    4. Role of triggering receptor expressed on myeloid cells-1/3 in Klebsiella-derived pneumosepsis. Hommes TJ, et al. Am J Respir Cell Mol Biol, 2015 Nov. PMID 25860078
    5. Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy. Tammaro A, et al. PLoS One, 2013. PMID 24358193, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice.
      Title: Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice.
    2. TREM-1/TREM-3 macrophage expression improved host defense against Klebsiella-derived pneumosepsis, whereas TREM-2 did not have a role.
      Title: Role of triggering receptor expressed on myeloid cells-1/3 in Klebsiella-derived pneumosepsis.
    3. Like TREM-1 and TREM-2, TREM-3 signals through DAP12.
      Title: Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables lipoteichoic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within chemokine production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokine production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytokine production involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytokine production involved in immune response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neutrophil chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neutrophil extravasation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neutrophil-mediated killing of gram-negative bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neutrophil-mediated killing of gram-negative bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    triggering receptor expressed on myeloid cells 3
    Names
    triggering receptor expressed on monocytes 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021407.3 → NP_067382.1  triggering receptor expressed on myeloid cells 3 precursor

      See identical proteins and their annotated locations for NP_067382.1

      Status: REVIEWED

      Source sequence(s)
      AC241601, AK079407, BY594056
      Consensus CDS
      CCDS28861.1
      UniProtKB/Swiss-Prot
      Q9JKE1
      Related
      ENSMUSP00000044478.6, ENSMUST00000048065.6
      Conserved Domains (1) summary
      cl11960
      Location:30 → 112
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      48554707..48565876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317592.3 → XP_017173081.1  triggering receptor expressed on myeloid cells 3 isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:3 → 70
      Ig; Immunoglobulin domain

    2. XM_006524731.3 → XP_006524794.1  triggering receptor expressed on myeloid cells 3 isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:3 → 70
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JKE1.1 GenPept UniProtKB/Swiss-Prot:Q9JKE1

    Gene LinkOut

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