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    St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 20449, updated on 27-Nov-2024

    Summary

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    Official Symbol
    St8sia1provided by MGI
    Official Full Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1provided by MGI
    Primary source
    MGI:MGI:106011
    See related
    Ensembl:ENSMUSG00000030283 AllianceGenome:MGI:106011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GD3S; Sia-T; Siat8; Siat8a; 9330109E03Rik
    Summary
    Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Acts upstream of or within cellular response to heat and positive regulation of epithelial cell proliferation. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 5.6), kidney adult (RPKM 5.0) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St8sia1 in Genome Data Viewer
    Location:
    6 G3; 6 74.78 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142767267..142935247, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142821541..142989528, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10416 Neighboring gene predicted gene, 53249 Neighboring gene cytidine monophospho-N-acetylneuraminic acid synthetase Neighboring gene predicted gene, 46981 Neighboring gene sulfotransferase family 6B, member 2 Neighboring gene predicted gene 7457 Neighboring gene STARR-seq mESC enhancer starr_17714 Neighboring gene STARR-seq mESC enhancer starr_17715 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:142866014-142866248 Neighboring gene STARR-seq mESC enhancer starr_17718 Neighboring gene predicted gene 7468 Neighboring gene STARR-seq mESC enhancer starr_17722 Neighboring gene C2 calcium-dependent domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E2807 Neighboring gene STARR-seq mESC enhancer starr_17724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:143063726-143063909 Neighboring gene predicted gene, 31108 Neighboring gene STARR-seq mESC enhancer starr_17725 Neighboring gene STARR-positive B cell enhancer ABC_E2808 Neighboring gene predicted gene, 38921

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GD3 synthase deletion alters retinal structure and impairs visual function in mice. Abreu CA, et al. J Neurochem, 2021 Aug. PMID 34081777
    2. Different response of the knockout mice lacking b-series gangliosides against botulinum and tetanus toxins. Kitamura M, et al. Biochim Biophys Acta, 2005 Jun 30. PMID 15919183
    3. Intracranial V. cholerae sialidase protects against excitotoxic neurodegeneration. Dhanushkodi A, et al. PLoS One, 2011. PMID 22195039, Free PMC Article
    4. Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration. Akkhawattanangkul Y, et al. Genes Brain Behav, 2017 Jun. PMID 28239983, Free PMC Article
    5. GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation. Handa Y, et al. Pain, 2005 Oct. PMID 16150545

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of biochemical features of ST8 alpha-N-acetyl-neuraminide alpha2,8-sialyltransferase (St8sia) 5 isoforms.
      Title: Analysis of biochemical features of ST8 α-N-acetyl-neuraminide α2,8-sialyltransferase (St8sia) 5 isoforms.
    2. Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression.
      Title: Caveolin-1 knockout mice have altered serum N-glycan profile and sialyltransferase tissue expression.
    3. Knockdown of lncRNA MIR44352HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/betacatenin signaling pathway.
      Title: Knockdown of lncRNA MIR4435‑2HG and ST8SIA1 expression inhibits the proliferation, invasion and migration of prostate cancer cells in vitro and in vivo by blocking the activation of the FAK/AKT/β‑catenin signaling pathway.
    4. Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia.
      Title: Ganglioside GD3 is up-regulated in microglia and regulates phagocytosis following global cerebral ischemia.
    5. GD3 synthase deletion alters retinal structure and impairs visual function in mice.
      Title: GD3 synthase deletion alters retinal structure and impairs visual function in mice.
    6. Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model.
      Title: Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model.
    7. Deletion of GD3 synthase attenuates bone loss that emerges with aging.
      Title: Deficiency of GD3 Synthase in Mice Resulting in the Attenuation of Bone Loss with Aging.
    8. Targeted deletion of GD3S protects substantia nigra degeneration and prevents motor deficits associated with MPTP-poisoning.
      Title: Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration.
    9. leptin/ObRb-mediated signals were enhanced in hypothalamus of GD3S KO mice due to increased a-series gangliosides, leading to the apparently similar features of energy expenditure between the KO and wild type mice
      Title: Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice.
    10. role of GD3 synthase in sciatic nerve and neuronal morphology during peripheral nerve regeneration
      Title: Mice lacking GD3 synthase display morphological abnormalities in the sciatic nerve and neuronal disturbances during peripheral nerve regeneration.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-N-acetylneuraminide alpha-2,8-sialyltransferase
    Names
    GD3 synthase
    SIAT8-A
    ST8Sia I
    ST8SiaI
    alpha-2, 8-sialyltransferase
    alpha-2,8-sialyltransferase 8A
    ganglioside GD3 synthase
    ganglioside GT3 synthase
    sialyltransferase 8 A
    sialyltransferase 8A
    sialyltransferase St8Sia I
    sialytransferase St8Sia I
    NP_035504.2
    XP_006506991.1
    XP_006506992.1
    XP_006506993.1
    XP_011239876.1
    XP_011239877.1
    XP_011239878.1
    XP_017176961.1
    XP_030111143.1
    XP_036021874.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011374.2 → NP_035504.2  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

      See identical proteins and their annotated locations for NP_035504.2

      Status: VALIDATED

      Source sequence(s)
      AC122483, BC024821
      Consensus CDS
      CCDS20689.1
      UniProtKB/Swiss-Prot
      Q64687, Q8K1C1
      UniProtKB/TrEMBL
      Q8BWI0
      Related
      ENSMUSP00000032421.4, ENSMUST00000032421.4
      Conserved Domains (1) summary
      pfam00777
      Location:91 → 343
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      142767267..142935247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241575.3 → XP_011239877.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

      See identical proteins and their annotated locations for XP_011239877.1

      UniProtKB/TrEMBL
      Q3V3B1, Q64468
      Conserved Domains (1) summary
      pfam00777
      Location:11 → 263
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_006506929.4 → XP_006506992.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006506992.1

      UniProtKB/TrEMBL
      Q3V3B1, Q64468
      Conserved Domains (1) summary
      pfam00777
      Location:11 → 263
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_006506930.5 → XP_006506993.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006506993.1

      UniProtKB/TrEMBL
      Q3V3B1, Q64468
      Conserved Domains (1) summary
      pfam00777
      Location:11 → 263
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_017321472.3 → XP_017176961.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X4

      Conserved Domains (1) summary
      pfam00777
      Location:20 → 200
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_030255283.1 → XP_030111143.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X4

      Conserved Domains (1) summary
      pfam00777
      Location:20 → 200
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. XM_006506928.4 → XP_006506991.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006506991.1

      UniProtKB/TrEMBL
      Q3V3B1, Q64468
      Conserved Domains (1) summary
      pfam00777
      Location:11 → 263
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. XM_011241574.2 → XP_011239876.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X1

      UniProtKB/TrEMBL
      Q64468
      Conserved Domains (1) summary
      pfam00777
      Location:20 → 272
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    8. XM_011241576.4 → XP_011239878.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X3

      Conserved Domains (1) summary
      pfam00777
      Location:91 → 198
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    9. XM_036165981.1 → XP_036021874.1  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X5

      Conserved Domains (1) summary
      pfam00777
      Location:91 → 194
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64687.2 GenPept UniProtKB/Swiss-Prot:Q64687

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