Clint1 clathrin interactor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clint1provided by MGI
Official Full Name: clathrin interactor 1provided by MGI
Primary source: MGI:MGI:2144243
See related: Ensembl:ENSMUSG00000006169 AllianceGenome:MGI:2144243
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Enth; Epn4; C530049I24Rik; F630206G17Rik
Summary: Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in clathrin coat assembly and endocytosis. Predicted to be located in Golgi apparatus; clathrin-coated vesicle; and nucleoplasm. Predicted to be part of clathrin vesicle coat. Predicted to be active in endosome and plasma membrane. Is expressed in several structures, including craniocervical region bone; respiratory system cartilage; salivary gland primordium; sensory organ; and thoracic segment skeleton. Orthologous to human CLINT1 (clathrin interactor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 47.1), genital fat pad adult (RPKM 44.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.1; 11 27.45 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (45742797..45801452)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (45851944..45910625)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLLP recruits the clathrin adaptor EpsinR to sort the SNARE machinery of the endolysosomal pathway into the subapical compartment, which is a switch for polarized endocytosis.
Title: Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs.
EpsinR plays a role in antigen presentation, which provides insight into the mechanism of presentation pathway of endogenous MHC class II-restricted antigen.
Title: EpsinR, a target for pyrenocine B, role in endogenous MHC-II-restricted antigen presentation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236562

NoName (e-PCR)
- UniSTS:236564

42.MMHAP50FRF12.seq (e-PCR)
- UniSTS:124462

AW537616 (e-PCR)
- UniSTS:181329

RH134426 (e-PCR)
- UniSTS:217706

AI642036 (e-PCR)
- UniSTS:164460

G67081 (e-PCR)
- UniSTS:178290

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in clathrin coat assembly	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of clathrin vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated vesicle	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: clathrin interactor 1

Names: ENTH domain containing protein; enthoprotin; epsin 4; epsin-related protein; epsinR

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045520.5 → NP_001038985.2 clathrin interactor 1 isoform 1

See identical proteins and their annotated locations for NP_001038985.2

Status: VALIDATED

Source sequence(s)

AL645948

Consensus CDS

CCDS36130.1

UniProtKB/TrEMBL

Q3UPG6, Q5SUH7

Related

ENSMUSP00000104883.2, ENSMUST00000109260.3

Conserved Domains (2) summary

cd03571
Location:23 → 146

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...

pfam15279
Location:378 → 563

SOBP; Sine oculis-binding protein
NM_001346760.3 → NP_001333689.1 clathrin interactor 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL645948

Consensus CDS

CCDS83796.1

UniProtKB/TrEMBL

Q3UPG6, Q5SUH6

Related

ENSMUSP00000104884.4, ENSMUST00000109261.11
NM_001363484.2 → NP_001350413.1 clathrin interactor 1 isoform 3

Status: VALIDATED

Source sequence(s)

AL645948

UniProtKB/TrEMBL

Q3UPG6

Conserved Domains (3) summary

cd03571
Location:23 → 146

ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...

pfam09606
Location:467 → 587

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13634
Location:329 → 412

Nucleoporin_FG; Nucleoporin FG repeat region
NM_001404779.1 → NP_001391708.1 clathrin interactor 1 isoform 4

Status: VALIDATED

Source sequence(s)

AL645948
NM_001404780.1 → NP_001391709.1 clathrin interactor 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL645948
NM_001404781.1 → NP_001391710.1 clathrin interactor 1 isoform 6

Status: VALIDATED

Source sequence(s)

AL645948
NM_001404782.1 → NP_001391711.1 clathrin interactor 1 isoform 7

Status: VALIDATED

Source sequence(s)

AL645948
NM_001404784.1 → NP_001391713.1 clathrin interactor 1 isoform 8

Status: VALIDATED

Source sequence(s)

AL645948