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    BCAR3 BCAR3 adaptor protein, NSP family member [ Homo sapiens (human) ]

    Gene ID: 8412, updated on 10-Dec-2024

    Summary

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    Official Symbol
    BCAR3provided by HGNC
    Official Full Name
    BCAR3 adaptor protein, NSP family memberprovided by HGNC
    Primary source
    HGNC:HGNC:973
    See related
    Ensembl:ENSG00000137936 MIM:604704; AllianceGenome:HGNC:973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIG7; NSP2; AND-34; SH2D3B
    Summary
    Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
    Expression
    Ubiquitous expression in fat (RPKM 13.8), placenta (RPKM 6.5) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BCAR3 in Genome Data Viewer
    Location:
    1p22.1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (93561741..93848151, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (93407475..93693898, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (94027298..94313707, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene formin binding protein 1 like Neighboring gene RNA, 5S ribosomal pseudogene 53 Neighboring gene tRNA-Cys (anticodon GCA) 7-1 Neighboring gene Sharpr-MPRA regulatory region 13550 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:94018571-94019099 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:94038039-94039036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:94050266-94050778 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94054146-94054690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94054691-94055235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:94057721-94058221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:94075253-94075816 Neighboring gene BCAR3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94079051-94079704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94079705-94080357 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94081011-94081663 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94082971-94083623 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94101848-94102406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:94102407-94102965 Neighboring gene Sharpr-MPRA regulatory region 755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94104972-94105607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1333 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94109607-94110328 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:94127441-94128640 Neighboring gene Sharpr-MPRA regulatory region 8830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1084 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:94158555-94159754 Neighboring gene uncharacterized LOC102723480 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:94166702-94167901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1337 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1085 Neighboring gene Sharpr-MPRA regulatory region 5000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1341 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:94203124-94204323 Neighboring gene Sharpr-MPRA regulatory region 10321 Neighboring gene MPRA-validated peak324 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94261424-94262012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:94279629-94280169 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:94298677-94299315 Neighboring gene MPRA-validated peak325 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1087 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:94312484-94313274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1343 Neighboring gene tRNA-Arg (anticodon TCT) 1-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:94344769-94345584 Neighboring gene microRNA 760 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:94356477-94356625 Neighboring gene deoxynucleotidyltransferase terminal interacting protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1090 Neighboring gene glutamate-cysteine ligase modifier subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes. Guo J, et al. Breast Cancer Res, 2014 Dec 13. PMID 25499443, Free PMC Article
    2. Translation of an atypical human cDNA requires fidelity of apurine-pyrimidine repeat region and recoding. Petty AP, et al. Gene, 2008 May 15. PMID 18378409
    3. Mig-7 expression and vasculogenic mimicry in malignant ovarian tumors. Czekierdowski A, et al. Ginekol Pol, 2017. PMID 29192416
    4. MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma. Qu B, et al. Oncol Rep, 2018 Feb. PMID 29251318
    5. [MIG7 Regulates the Vasculogenic Mimicry Formation in Hepatocellular Carcinoma then Effects the Metastasis Potential of HCC]. Qu B, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2017 May. PMID 28616909

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircBCAR3 sponges miR-27a-3p and mediates ferroptosis in human B-prolymphocytic leukaemia cells via SLC7A11.
      Title: CircBCAR3 sponges miR-27a-3p and mediates ferroptosis in human B-prolymphocytic leukaemia cells via SLC7A11.
    2. Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes.
      Title: Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes.
    3. A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics.
      Title: A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics.
    4. MIG-7 mRNA expression may serve as an additional molecular marker of vasculogenic mimicry in ovarian malignancies.
      Title: Mig-7 expression and vasculogenic mimicry in malignant ovarian tumors.
    5. Study provides evidence that MIG7 expression in hepatocellular carcinoma (HCC) tissue is correlated positively with vasculogenic mimicry (VM) formation and MIG7 expression in different HCC cell lines is coincident with their VM formation, invasion and metastasis.
      Title: MIG7 is involved in vasculogenic mimicry formation rendering invasion and metastasis in hepatocellular carcinoma.
    6. this study indicates that the expression of Mig-7 in gliomas is positively correlated with vasculogenic mimicry formation and is related to the glioma pathological grade
      Title: Silencing of Mig-7 expression inhibits in-vitro invasiveness and vasculogenic mimicry of human glioma U87 Cells.
    7. MIG-7 serves as an independent unfavorable prognostic indicator in osteosarcoma patients and MIG-7 is an important mediator of osteosarcoma Vascular Mimicry formation.
      Title: Migration-inducing gene-7 independently predicts poor prognosis of human osteosarcoma and is associated with vasculogenic mimicry.
    8. The high expressions of Mig-7 and MMP-2 in gastric carcinoma tissues may have a synergistic promoting effect on VM formation. VM is closely associated with the invasion, metastasis and poor prognosis of gastric carcinoma.
      Title: [Expressions and clinical significance of vasculogenic mimicry and related protein Mig-7 and MMP-2 in gastric carcinoma].
    9. MIG7 expression in hepatocellular carcinoma tissue is high and correlated positively with vasculogenic mimicry formation, invasion and metastasis.
      Title: [MIG7 Regulates the Vasculogenic Mimicry Formation in Hepatocellular Carcinoma then Effects the Metastasis Potential of HCC].
    10. Silencing of Mig-7 gene inhibits vasculogenic mimicry formation and invasion of U251 cells possibly by suppressing MEK/ERK signaling, suggesting the important role of Mig-7 gene in vasculogenic mimicry formation and invasion of human glioma cells
      Title: [Mig-7 gene silencing inhibits vasculogenic mimicry formation and invasion of glioma U251 cells in vitro by suppressing MEK/ERK signaling].
    Submit: New GeneRIF Correction See all GeneRIFs (29)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0554

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endothelin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endothelin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lens morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    breast cancer anti-estrogen resistance protein 3
    Names
    BCAR3, NSP family adaptor protein
    SH2 domain-containing protein 3B
    breast cancer anti-estrogen resistance 3
    breast cancer antiestrogen resistance 3 protein
    dJ1033H22.2 (breast cancer anti-estrogen resistance 3)
    epididymis secretory sperm binding protein
    mig-7
    migration inducting gene-7
    novel SH2-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261408.2 → NP_001248337.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001248337.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AL049796, AL109613, BC028477, BQ015705
      Consensus CDS
      CCDS745.1
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06
      Related
      ENSP00000359264.1, ENST00000370244.5
      Conserved Domains (2) summary
      cd10337
      Location:147 → 282
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      smart00147
      Location:544 → 819
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    2. NM_001261409.1 → NP_001248338.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001248338.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AK027785, AK055442, BQ015705, DA745974
      Consensus CDS
      CCDS745.1
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06
      Related
      ENSP00000359263.1, ENST00000370243.1
      Conserved Domains (2) summary
      cd10337
      Location:147 → 282
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      smart00147
      Location:544 → 819
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    3. NM_001261410.2 → NP_001248339.1  breast cancer anti-estrogen resistance protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001248339.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL109613, AL833121, BQ015705
      Consensus CDS
      CCDS58010.1
      UniProtKB/TrEMBL
      B3KP06
      Related
      ENSP00000359267.3, ENST00000370247.7
      Conserved Domains (2) summary
      cd10337
      Location:56 → 191
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      smart00147
      Location:453 → 728
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    4. NM_001308251.1 → NP_001295180.1  breast cancer anti-estrogen resistance protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001295180.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a significantly shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK310970, AW470748, AY358996
      Consensus CDS
      CCDS76181.1
      UniProtKB/TrEMBL
      B4DWK2
      Related
      ENSP00000441343.1, ENST00000539242.5
      Conserved Domains (1) summary
      smart00147
      Location:220 → 495
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    5. NM_001412043.1 → NP_001398972.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL109613, AL359820
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06

    6. NM_001412044.1 → NP_001398973.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL109613, AL359820
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06

    7. NM_001412045.1 → NP_001398974.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL109613, AL359820
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06

    8. NM_001412046.1 → NP_001398975.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL109613, AL359820
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06

    9. NM_001412048.1 → NP_001398977.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL109613, AL359820
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06

    10. NM_001412049.1 → NP_001398978.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL109613, AL359820
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06

    11. NM_001412050.1 → NP_001398979.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06

    12. NM_001412051.1 → NP_001398980.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06

    13. NM_001412052.1 → NP_001398981.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06

    14. NM_001412054.1 → NP_001398983.1  breast cancer anti-estrogen resistance protein 3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL109613, AL359820
      UniProtKB/TrEMBL
      B3KP06

    15. NM_001412055.1 → NP_001398984.1  breast cancer anti-estrogen resistance protein 3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL109613, AL359820
      UniProtKB/TrEMBL
      B3KP06

    16. NM_001412056.1 → NP_001398985.1  breast cancer anti-estrogen resistance protein 3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL109613, AL359820
      UniProtKB/TrEMBL
      B3KP06

    17. NM_001412057.1 → NP_001398986.1  breast cancer anti-estrogen resistance protein 3 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820
      UniProtKB/TrEMBL
      B3KP06

    18. NM_001412058.1 → NP_001398987.1  breast cancer anti-estrogen resistance protein 3 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820
      UniProtKB/TrEMBL
      B3KNL6, B4DWK2

    19. NM_001412059.1 → NP_001398988.1  breast cancer anti-estrogen resistance protein 3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820
      UniProtKB/TrEMBL
      B3KP06

    20. NM_001412060.1 → NP_001398989.1  breast cancer anti-estrogen resistance protein 3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820
      UniProtKB/TrEMBL
      B3KP06

    21. NM_001412061.1 → NP_001398990.1  breast cancer anti-estrogen resistance protein 3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820
      UniProtKB/TrEMBL
      B3KP06

    22. NM_001412062.1 → NP_001398991.1  breast cancer anti-estrogen resistance protein 3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820
      UniProtKB/TrEMBL
      B3KP06

    23. NM_001412064.1 → NP_001398993.1  breast cancer anti-estrogen resistance protein 3 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820
      UniProtKB/TrEMBL
      B3KP06

    24. NM_001412065.1 → NP_001398994.1  breast cancer anti-estrogen resistance protein 3 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820

    25. NM_001412066.1 → NP_001398995.1  breast cancer anti-estrogen resistance protein 3 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820

    26. NM_001412067.1 → NP_001398996.1  breast cancer anti-estrogen resistance protein 3 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820

    27. NM_001412072.1 → NP_001399001.1  breast cancer anti-estrogen resistance protein 3 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820

    28. NM_001412073.1 → NP_001399002.1  breast cancer anti-estrogen resistance protein 3 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820
      UniProtKB/TrEMBL
      B3KP06

    29. NM_001412074.1 → NP_001399003.1  breast cancer anti-estrogen resistance protein 3 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AL109613
      UniProtKB/TrEMBL
      B3KP06

    30. NM_001412075.1 → NP_001399004.1  breast cancer anti-estrogen resistance protein 3 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL109613

    31. NM_001412076.1 → NP_001399005.1  breast cancer anti-estrogen resistance protein 3 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL109613
      UniProtKB/TrEMBL
      B3KP06

    32. NM_001412077.1 → NP_001399006.1  breast cancer anti-estrogen resistance protein 3 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL109613
      UniProtKB/TrEMBL
      B3KNL6, B4DWK2

    33. NM_003567.4 → NP_003558.1  breast cancer anti-estrogen resistance protein 3 isoform 1

      See identical proteins and their annotated locations for NP_003558.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AF124250, AL109613, BQ015705, CN337133
      Consensus CDS
      CCDS745.1
      UniProtKB/Swiss-Prot
      D3DT43, O75815, Q5TEW3, Q6UW40, Q9BR50
      UniProtKB/TrEMBL
      A0A384MTS3, B3KP06
      Related
      ENSP00000260502.6, ENST00000260502.11
      Conserved Domains (2) summary
      cd10337
      Location:147 → 282
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      smart00147
      Location:544 → 819
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    RNA

    1. NR_148965.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL512488
      Related
      ENST00000433544.1

    2. NR_171551.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL512488

    3. NR_178002.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796

    4. NR_178003.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL512488

    5. NR_178005.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796

    6. NR_178006.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL512488

    7. NR_178007.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796

    8. NR_178009.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796

    9. NR_178010.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL512488

    10. NR_178011.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL512488

    11. NR_178013.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL359820

    12. NR_178014.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796

    13. NR_178015.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796

    14. NR_178016.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL359820

    15. NR_178017.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL512488

    16. NR_178018.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL512488

    17. NR_178021.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL512488

    18. NR_178022.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL049796, AL512488

    19. NR_178023.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820

    20. NR_178024.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL109613, AL359820

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      93561741..93848151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      93407475..93693898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75815.1 GenPept UniProtKB/Swiss-Prot:O75815

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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