PXN paxillin [Homo sapiens (human)] - Gene

Summary

Official Symbol: PXNprovided by HGNC
Official Full Name: paxillinprovided by HGNC
Primary source: HGNC:HGNC:9718
See related: Ensembl:ENSG00000089159 MIM:602505; AllianceGenome:HGNC:9718
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
Expression: Ubiquitous expression in placenta (RPKM 24.8), fat (RPKM 20.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.23

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (120210447..120265730, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (120197626..120252894, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (120648250..120703533, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions.
Title: Paxillin regulates androgen receptor expression associated with granulosa cell focal adhesions.
ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
Title: ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
Paxillin phase separation promotes focal adhesion assembly and integrin signaling.
Title: Paxillin phase separation promotes focal adhesion assembly and integrin signaling.
Effect of Paxillin Expression and Phosphorylation on Colorectal Cancer Prognosis and Metastasis.
Title: Effect of Paxillin Expression and Phosphorylation on Colorectal Cancer Prognosis and Metastasis.
Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.
Title: Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.
Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
Title: Paxillin/HDAC6 regulates microtubule acetylation to promote directional migration of keratinocytes driven by electric fields.
Extraciliary OFD1 Is Involved in Melanocyte Survival through Cell Adhesion to ECM via Paxillin.
Title: Extraciliary OFD1 Is Involved in Melanocyte Survival through Cell Adhesion to ECM via Paxillin.
Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.
Title: Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells.
An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.
Title: An ULK1/2-PXN mechanotransduction pathway suppresses breast cancer cell migration.
Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.
Title: Serum claudin-5, claudin-11, occludin, vinculin, paxillin, and beta-catenin levels in preschool children with autism spectrum disorder.

Submit: New GeneRIF Correction See all GeneRIFs (183)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells	PubMed
Nef	nef	The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion	PubMed
	nef	The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation	PubMed
Tat	tat	Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes	PubMed
	tat	HIV-1 Tat stimulates the phosphorylation of paxillin and its association with RAFTK, an effect linked to Tat-induced angiogenesis and AIDS-related Kaposi's sarcoma	PubMed
matrix	gag	HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH36430 (e-PCR)
- UniSTS:91426

D11S2560 (e-PCR)
- UniSTS:37928

D12S1721 (e-PCR), detects polymorphism
- UniSTS:16176

RH78308 (e-PCR)
- UniSTS:15201

G64568 (e-PCR)
- UniSTS:163952

D15S1477 (e-PCR)
- UniSTS:474482

STS-AA002185 (e-PCR)
- UniSTS:44485

A001T32 (e-PCR)
- UniSTS:51448

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neuropilin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables vinculin binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to reactive oxygen species	IEP Inferred from Expression Pattern more info	PubMed
involved_in endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth hormone receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal complex assembly	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	HDA more info	PubMed
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
part_of microtubule associated complex	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: paxillin

Names: testicular tissue protein Li 134

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029820.1 RefSeqGene

Range

5042..60325

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001080855.3 → NP_001074324.1 paxillin isoform 2

See identical proteins and their annotated locations for NP_001074324.1

Status: REVIEWED

Source sequence(s)

BC144410, BU500419, BX648777, DB472926

Consensus CDS

CCDS44997.1

UniProtKB/Swiss-Prot

B2RAI3, B7ZMB4, O14970, O14971, O60360, P49023, Q5HYA4

UniProtKB/TrEMBL

A0A140VJQ8, B3KVL0

Related

ENSP00000228307.7, ENST00000228307.11

Conserved Domains (5) summary

cd09338
Location:476 → 528

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:417 → 468

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:535 → 586

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:358 → 410

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
NM_001243756.2 → NP_001230685.1 paxillin isoform 3

See identical proteins and their annotated locations for NP_001230685.1

Status: REVIEWED

Source sequence(s)

AC004263

Consensus CDS

CCDS58281.1

UniProtKB/TrEMBL

B3KVL0

Related

ENSP00000267257.7, ENST00000267257.11

Conserved Domains (5) summary

cd09338
Location:490 → 542

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:431 → 482

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:549 → 600

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:372 → 424

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
NM_001385981.1 → NP_001372910.1 paxillin isoform 5

Status: REVIEWED

Source sequence(s)

AC004263

Consensus CDS

CCDS91759.1

UniProtKB/TrEMBL

A0A1B0GTU4

Related

ENSP00000489840.1, ENST00000637617.2

Conserved Domains (6) summary

cd09338
Location:966 → 1018

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:907 → 958

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:1025 → 1076

LIM4_Paxillin; The fourth LIM domain of Paxillin

PHA03247
Location:314 → 606

PHA03247; large tegument protein UL36; Provisional

cd09336
Location:848 → 900

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
NM_001385982.1 → NP_001372911.1 paxillin isoform 6

Status: REVIEWED

Source sequence(s)

AC004263

Conserved Domains (5) summary

cd09338
Location:874 → 926

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:815 → 866

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:933 → 984

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:756 → 808

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
NM_001385983.1 → NP_001372912.1 paxillin isoform 7

Status: REVIEWED

Source sequence(s)

AC004263

Conserved Domains (5) summary

cd09338
Location:872 → 924

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:813 → 864

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:931 → 982

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:754 → 806

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
NM_001385984.1 → NP_001372913.1 paxillin isoform 8

Status: REVIEWED

Source sequence(s)

AC004263

Conserved Domains (6) summary

cd09338
Location:785 → 837

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:726 → 777

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:844 → 895

LIM4_Paxillin; The fourth LIM domain of Paxillin

PHA03247
Location:314 → 553

PHA03247; large tegument protein UL36; Provisional

cd09336
Location:667 → 719

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
NM_001385985.1 → NP_001372914.1 paxillin isoform 9

Status: REVIEWED

Source sequence(s)

AC004263

Conserved Domains (6) summary

cd09338
Location:737 → 789

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:678 → 729

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:796 → 847

LIM4_Paxillin; The fourth LIM domain of Paxillin

PHA03247
Location:314 → 553

PHA03247; large tegument protein UL36; Provisional

cd09336
Location:619 → 671

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
NM_001385986.1 → NP_001372915.1 paxillin isoform 10

Status: REVIEWED

Source sequence(s)

AC004263

Conserved Domains (6) summary

cd09338
Location:625 → 677

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:566 → 617

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:684 → 735

LIM4_Paxillin; The fourth LIM domain of Paxillin

PHA03307
Location:91 → 459

PHA03307; transcriptional regulator ICP4; Provisional

cd09336
Location:507 → 559

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
NM_001385987.1 → NP_001372916.1 paxillin isoform 11

Status: REVIEWED

Source sequence(s)

AC004263

UniProtKB/TrEMBL

B3KVL0

Conserved Domains (5) summary

cd09338
Location:579 → 631

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:520 → 571

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:638 → 689

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:461 → 513

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
NM_001385988.1 → NP_001372917.1 paxillin isoform 12

Status: REVIEWED

Source sequence(s)

AC004263

UniProtKB/TrEMBL

B3KVL0

Conserved Domains (4) summary

cd09407
Location:465 → 516

LIM2_Paxillin; The second LIM domain of paxillin

cd09336
Location:406 → 458

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family

cl02475
Location:524 → 550

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001385989.1 → NP_001372918.1 paxillin isoform 13

Status: REVIEWED

Source sequence(s)

AC004263

UniProtKB/TrEMBL

B3KVL0

Conserved Domains (4) summary

cd09407
Location:415 → 466

LIM2_Paxillin; The second LIM domain of paxillin

cd09336
Location:356 → 408

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family

cl02475
Location:474 → 500

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001385990.1 → NP_001372919.1 paxillin isoform 14

Status: REVIEWED

Source sequence(s)

AC004263

Conserved Domains (4) summary

cd09407
Location:383 → 434

LIM2_Paxillin; The second LIM domain of paxillin

cd09336
Location:324 → 376

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family

cl02475
Location:442 → 468

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001410986.1 → NP_001397915.1 paxillin isoform 15

Status: REVIEWED

Source sequence(s)

AC004263

Consensus CDS

CCDS91758.1

UniProtKB/TrEMBL

B3KVL0, F5GZ78

Related

ENSP00000443887.1, ENST00000536957.5
NM_002859.4 → NP_002850.2 paxillin isoform 1

See identical proteins and their annotated locations for NP_002850.2

Status: REVIEWED

Source sequence(s)

BC136794, BC144410, BU500419, BX648777, DB472926

Consensus CDS

CCDS44996.1

UniProtKB/TrEMBL

B3KVL0

Related

ENSP00000391283.2, ENST00000424649.6

Conserved Domains (5) summary

cd09338
Location:442 → 494

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:383 → 434

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:501 → 552

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:324 → 376

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
NM_025157.5 → NP_079433.3 paxillin isoform 4

See identical proteins and their annotated locations for NP_079433.3

Status: REVIEWED

Source sequence(s)

AC004263, BC136794, BC144410, BU500419, BX648777, DA565031

Consensus CDS

CCDS44998.1

UniProtKB/Swiss-Prot

P49023

Related

ENSP00000395536.2, ENST00000458477.6

Conserved Domains (4) summary

cd09338
Location:309 → 361

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09336
Location:191 → 243

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

cl02475
Location:250 → 301

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam03535
Location:1 → 120

Paxillin; Paxillin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

120210447..120265730 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047429246.1 → XP_047285202.1 paxillin isoform X15

UniProtKB/TrEMBL

B3KVL0
XM_047429241.1 → XP_047285197.1 paxillin isoform X9

UniProtKB/TrEMBL

B3KVL0
XM_047429240.1 → XP_047285196.1 paxillin isoform X8

UniProtKB/TrEMBL

B3KVL0
XM_047429239.1 → XP_047285195.1 paxillin isoform X7
XM_006719532.3 → XP_006719595.1 paxillin isoform X2

Conserved Domains (5) summary

cd09338
Location:1014 → 1066

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:955 → 1006

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:1073 → 1124

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:896 → 948

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:54 → 253

Paxillin; Paxillin family
XM_011538622.2 → XP_011536924.1 paxillin isoform X3

See identical proteins and their annotated locations for XP_011536924.1

Conserved Domains (5) summary

cd09338
Location:881 → 933

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:822 → 873

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:940 → 991

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:763 → 815

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:1 → 120

Paxillin; Paxillin family
XM_047429236.1 → XP_047285192.1 paxillin isoform X1
XM_047429250.1 → XP_047285206.1 paxillin isoform X19

UniProtKB/TrEMBL

B3KVL0
XM_047429243.1 → XP_047285199.1 paxillin isoform X12

UniProtKB/TrEMBL

B3KVL0
XM_047429249.1 → XP_047285205.1 paxillin isoform X18

UniProtKB/TrEMBL

B3KVL0
XM_047429242.1 → XP_047285198.1 paxillin isoform X11

UniProtKB/TrEMBL

B3KVL0
XM_047429244.1 → XP_047285200.1 paxillin isoform X14

UniProtKB/TrEMBL

B3KVL0
XM_017019742.3 → XP_016875231.1 paxillin isoform X17

UniProtKB/TrEMBL

B3KVL0

Conserved Domains (5) summary

cd09338
Location:448 → 500

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:389 → 440

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:507 → 558

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:330 → 382

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:60 → 259

Paxillin; Paxillin family
XM_017019739.3 → XP_016875228.1 paxillin isoform X10

UniProtKB/TrEMBL

B3KVL0

Conserved Domains (5) summary

cd09338
Location:496 → 548

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:437 → 488

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:555 → 606

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:378 → 430

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:60 → 259

Paxillin; Paxillin family
XM_017019740.3 → XP_016875229.1 paxillin isoform X13

UniProtKB/TrEMBL

B3KVL0

Conserved Domains (5) summary

cd09338
Location:482 → 534

LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family

cd09407
Location:423 → 474

LIM2_Paxillin; The second LIM domain of paxillin

cd09411
Location:541 → 592

LIM4_Paxillin; The fourth LIM domain of Paxillin

cd09336
Location:364 → 416

LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family

pfam03535
Location:60 → 259

Paxillin; Paxillin family
XM_047429252.1 → XP_047285208.1 paxillin isoform X21
XM_047429253.1 → XP_047285209.1 paxillin isoform X22
XM_047429251.1 → XP_047285207.1 paxillin isoform X20
XM_047429238.1 → XP_047285194.1 paxillin isoform X6
XM_047429237.1 → XP_047285193.1 paxillin isoform X5
XM_047429248.1 → XP_047285204.1 paxillin isoform X16
XM_017019732.3 → XP_016875221.2 paxillin isoform X4