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    FEI2 Leucine-rich repeat protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818130, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FEI2
    Official Full Name
    Leucine-rich repeat protein kinase family protein
    Primary source
    TAIR:AT2G35620
    Locus tag
    AT2G35620
    See related
    Araport:AT2G35620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FEI 2; T20F21.18; T20F21_18
    Summary
    Encodes a plasma membrane localized leucine-rich repeat receptor kinase that is involved in cell wall elongation. Loss of function mutations of FEI1 and FEI2 exhibit defects in root and hypocotyl cell elongation. Double mutants are defective in cell wall biosynthesis and have thick hypocotyls, and short, thick roots.
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    Genomic context

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    See FEI2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Sequence:
    Chromosome: 2; NC_003071.7 (14960851..14965497, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Eukaryotic aspartyl protease family protein Neighboring gene ARM repeat superfamily protein Neighboring gene ubiquitin 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defects in the cell wall and its deposition caused by loss-of-function of three RLKs alter root hydrotropism in Arabidopsis thaliana. Chang J, et al. Nat Commun, 2024 Mar 26. PMID 38531848, Free PMC Article
    2. The FEI2-SOS5 pathway and CELLULOSE SYNTHASE 5 are required for cellulose biosynthesis in the Arabidopsis seed coat and affect pectin mucilage structure. Harpaz-Saad S, et al. Plant Signal Behav, 2012 Feb. PMID 22353871, Free PMC Article
    3. Glycosylation of a Fasciclin-Like Arabinogalactan-Protein (SOS5) Mediates Root Growth and Seed Mucilage Adherence via a Cell Wall Receptor-Like Kinase (FEI1/FEI2) Pathway in Arabidopsis. Basu D, et al. PLoS One, 2016. PMID 26731606, Free PMC Article
    4. Highly Branched Xylan Made by IRREGULAR XYLEM14 and MUCILAGE-RELATED21 Links Mucilage to Arabidopsis Seeds. Voiniciuc C, et al. Plant Physiol, 2015 Dec. PMID 26482889, Free PMC Article
    5. Two leucine-rich repeat receptor kinases mediate signaling, linking cell wall biosynthesis and ACC synthase in Arabidopsis. Xu SL, et al. Plant Cell, 2008 Nov. PMID 19017745, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Arabidopsis proteins GALT2, GALT5, SOS5, FEI1 and FEI2 act in a single genetic signaling pathway.
      Title: Glycosylation of a Fasciclin-Like Arabinogalactan-Protein (SOS5) Mediates Root Growth and Seed Mucilage Adherence via a Cell Wall Receptor-Like Kinase (FEI1/FEI2) Pathway in Arabidopsis.
    2. we demonstrated that FEI2 and SOS5 regulate the production of the cellulosic rays deposited across the inner adherent-layer of seed mucilage.
      Title: The FEI2-SOS5 pathway and CELLULOSE SYNTHASE 5 are required for cellulose biosynthesis in the Arabidopsis seed coat and affect pectin mucilage structure.
    3. The protein kinases FEI1 and FEI2 help regulate cell expansion and cell wall biosynthesis through interaction with ACC synthase. [FEI2]
      Title: Two leucine-rich repeat receptor kinases mediate signaling, linking cell wall biosynthesis and ACC synthase in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001202755.2
    NM_001336565.1
    NM_001336566.1
    NM_129116.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mucilage biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mucilage biosynthetic process involved in seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mucilage biosynthetic process involved in seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plant-type cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat protein kinase family protein
    NP_001189684.1
    • FEI 2 (FEI2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT1G31420.2).
    NP_181105.2
    • FEI 2 (FEI2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT1G31420.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14960851..14965497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129116.5 → NP_181105.2  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LGL9, Q0WLU4, Q9ZQN5
      UniProtKB/TrEMBL
      A0A178VLP0, A0A5S9X477, A0A654EZ72
      Conserved Domains (3) summary
      PLN03150
      Location:59 → 257
      PLN03150; hypothetical protein; Provisional
      pfam08263
      Location:29 → 69
      LRRNT_2; Leucine rich repeat N-terminal domain
      cl21453
      Location:310 → 572
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001336565.1 → NP_001324113.1  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LGL9, Q0WLU4, Q9ZQN5
      UniProtKB/TrEMBL
      A0A178VLP0, A0A5S9X477, A0A654EZ72
      Conserved Domains (3) summary
      PLN03150
      Location:59 → 257
      PLN03150; hypothetical protein; Provisional
      pfam08263
      Location:29 → 69
      LRRNT_2; Leucine rich repeat N-terminal domain
      cl21453
      Location:310 → 572
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001202755.2 → NP_001189684.1  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LGL9, Q0WLU4, Q9ZQN5
      UniProtKB/TrEMBL
      A0A178VLP0, A0A5S9X477, A0A654EZ72
      Conserved Domains (3) summary
      PLN03150
      Location:59 → 257
      PLN03150; hypothetical protein; Provisional
      pfam08263
      Location:29 → 69
      LRRNT_2; Leucine rich repeat N-terminal domain
      cl21453
      Location:310 → 572
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001336566.1 → NP_001324112.1  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LGL9, Q0WLU4, Q9ZQN5
      UniProtKB/TrEMBL
      A0A178VLP0, A0A5S9X477, A0A654EZ72
      Conserved Domains (3) summary
      PLN03150
      Location:59 → 257
      PLN03150; hypothetical protein; Provisional
      pfam08263
      Location:29 → 69
      LRRNT_2; Leucine rich repeat N-terminal domain
      cl21453
      Location:310 → 572
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0LGL9.1

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