Usp33 ubiquitin specific peptidase 33 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp33provided by MGI
Official Full Name: ubiquitin specific peptidase 33provided by MGI
Primary source: MGI:MGI:2159711
See related: Ensembl:ENSMUSG00000025437 AllianceGenome:MGI:2159711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vdu1; 9830169D19Rik
Summary: Predicted to enable several functions, including cysteine-type peptidase activity; small GTPase binding activity; and zinc ion binding activity. Involved in axon guidance and cell migration. Located in neuronal cell body. Is expressed in central nervous system and retina. Orthologous to human USP33 (ubiquitin specific peptidase 33). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 26.3), CNS E14 (RPKM 24.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H3; 3 77.15 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (152051797..152099254)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (152346184..152393617)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway.
Title: miR-206 alleviates LPS-induced inflammatory injury in cardiomyocytes via directly targeting USP33 to inhibit the JAK2/STAT3 signaling pathway.
Knockdown or chemical inhibition of p97 causes robust accumulation of USP33 due to inhibition of its degradation
Title: Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.
Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling
Title: Midline crossing and Slit responsiveness of commissural axons require USP33.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in centrosome duplication	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 33

Names: VHL-interacting deubiquitinating enzyme 1; Vhlh-interacting deubiquitinating enzyme 1; deubiquitinating enzyme 33; pVHL-interacting deubiquitinating enzyme 1; ubiquitin specific protease 33; ubiquitin thioesterase 33; ubiquitin thiolesterase 33; ubiquitin-specific-processing protease 33

NP_001070144.1

EC 3.4.19.12

NP_001239415.1

EC 3.4.19.12

NP_001342595.1

EC 3.4.19.12

NP_573510.2

EC 3.4.19.12

XP_030108303.1

EC 3.4.19.12

XP_030108304.1

EC 3.4.19.12

XP_036018806.1

EC 3.4.19.12

XP_036018807.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076676.2 → NP_001070144.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses two alternate in-frame splice junctions compared to variant 1, resulting in a shorter protein (isoform 2).

Source sequence(s)

AA210301, AK082943, AK087467

Consensus CDS

CCDS80064.1

UniProtKB/TrEMBL

A0A0H2UKB8, Q80TK2

Related

ENSMUSP00000026507.8, ENSMUST00000026507.13

Conserved Domains (6) summary

smart00695
Location:799 → 879

DUSP; Domain in ubiquitin-specific proteases

cd02674
Location:441 → 672

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:155 → 287

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:153 → 671

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:30 → 90

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl12116
Location:693 → 762

DUSP; DUSP domain
NM_001252486.1 → NP_001239415.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1, resulting in a shorter protein (isoform 3).

Source sequence(s)

AA210301, AK087467, AK143844, BC089315

Consensus CDS

CCDS57261.1

UniProtKB/TrEMBL

Q80TK2

Related

ENSMUSP00000113265.4, ENSMUST00000117492.9

Conserved Domains (6) summary

smart00695
Location:799 → 883

DUSP; Domain in ubiquitin-specific proteases

cd02674
Location:441 → 672

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl02553
Location:155 → 287

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:153 → 671

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:30 → 90

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl12116
Location:693 → 762

DUSP; DUSP domain
NM_001355666.1 → NP_001342595.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 4

Status: VALIDATED

Source sequence(s)

AA210301, AC122529

UniProtKB/TrEMBL

Q80TK2

Conserved Domains (3) summary

pfam00443
Location:154 → 679

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:30 → 90

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl12116
Location:701 → 764

DUSP; DUSP domain
NM_133247.3 → NP_573510.2 ubiquitin carboxyl-terminal hydrolase 33 isoform 1

See identical proteins and their annotated locations for NP_573510.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AA210301, AK087467, AK143844, BC089315

Consensus CDS

CCDS17918.1

UniProtKB/Swiss-Prot

Q3UP32, Q5FWK0, Q8K0I3, Q8R5K2, Q99K22

UniProtKB/TrEMBL

Q80TK2

Related

ENSMUSP00000142708.2, ENSMUST00000197748.5

Conserved Domains (4) summary

smart00695
Location:807 → 891

DUSP; Domain in ubiquitin-specific proteases

pfam00443
Location:154 → 679

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:30 → 90

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl12116
Location:701 → 770

DUSP; DUSP domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

152051797..152099254

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162913.1 → XP_036018806.1 ubiquitin carboxyl-terminal hydrolase 33 isoform X2

UniProtKB/TrEMBL

Q80TK2

Conserved Domains (3) summary

pfam00443
Location:154 → 679

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:30 → 90

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl12116
Location:701 → 770

DUSP; DUSP domain
XM_036162914.1 → XP_036018807.1 ubiquitin carboxyl-terminal hydrolase 33 isoform X3

UniProtKB/TrEMBL

Q80TK2

Conserved Domains (3) summary

pfam00443
Location:154 → 671

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:30 → 90

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl12116
Location:693 → 762

DUSP; DUSP domain
XM_030252444.2 → XP_030108304.1 ubiquitin carboxyl-terminal hydrolase 33 isoform X4

UniProtKB/TrEMBL

Q80TK2

Conserved Domains (3) summary

pfam00443
Location:154 → 671

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:30 → 90

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl12116
Location:693 → 756

DUSP; DUSP domain
XM_030252443.2 → XP_030108303.1 ubiquitin carboxyl-terminal hydrolase 33 isoform X1

UniProtKB/Swiss-Prot

Q3UP32, Q5FWK0, Q8K0I3, Q8R5K2, Q99K22

UniProtKB/TrEMBL

Q80TK2

Conserved Domains (4) summary

smart00695
Location:807 → 891

DUSP; Domain in ubiquitin-specific proteases

pfam00443
Location:154 → 679

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam02148
Location:30 → 90

zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

cl12116
Location:701 → 770

DUSP; DUSP domain