SEC11A SEC11 homolog A, signal peptidase complex subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: SEC11Aprovided by HGNC
Official Full Name: SEC11 homolog A, signal peptidase complex subunitprovided by HGNC
Primary source: HGNC:HGNC:17718
See related: Ensembl:ENSG00000140612 MIM:618258; AllianceGenome:HGNC:17718
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik
Summary: This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Expression: Ubiquitous expression in thyroid (RPKM 67.9), fat (RPKM 55.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q25.2-q25.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (84669544..84716139, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (82421945..82500674, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (85212775..85259370, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs).
Title: CircSEC11A knockdown alleviates oxidative stress and apoptosis and promotes cell proliferation and angiogenesis by regulating miR-29a-3p/SEMA3A axis in OGD-induced human brain microvascular endothelial cells (HBMECs).
Clinical Significance of SEC11A Expression in Patients With Locally Advanced Gastric Cancer.
Title: Clinical Significance of SEC11A Expression in Patients With Locally Advanced Gastric Cancer.
MiR-873-5p modulates progression of tongue squamous cell carcinoma via targeting SEC11A.
Title: MiR-873-5p modulates progression of tongue squamous cell carcinoma via targeting SEC11A.
Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
Title: Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma.
Title: SPC18 Expression Is an Independent Prognostic Indicator of Patients with Esophageal Squamous Cell Carcinoma.
Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis.
Title: Long non-coding RNA DDX11-AS1 facilitates gastric cancer progression by regulating miR-873-5p/SPC18 axis.
These results indicate that SPC18 plays an important role in the progression of bladder cancer.
Title: SEC11A Expression Is Associated with Basal-Like Bladder Cancer and Predicts Patient Survival.
results suggest that SPC18 is involved in tumor progression, and is an independent prognostic classifier in patients with colorectal cancer
Title: Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression.
SPC18 contributes to malignant progression through promotion of TGF-alpha secretion in gastric cancer.
Title: Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in response to virus	TAS Traceable Author Statement more info
involved_in signal peptide processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
part_of signal peptidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of signal peptidase complex	IDA Inferred from Direct Assay more info	PubMed
part_of signal peptidase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: signal peptidase complex catalytic subunit SEC11A

Names: SEC11-like protein 1; SPase 18 kDa subunit; endopeptidase SP18; microsomal signal peptidase 18 kDa subunit; signal peptidase complex (18kD); signal peptidase complex 18

NP_001258847.1

EC 3.4.21.89

NP_001258848.1

EC 3.4.21.89

NP_001258849.1

EC 3.4.21.89

NP_001258850.1

EC 3.4.21.89

NP_001258851.1

EC 3.4.21.89

NP_055115.1

EC 3.4.21.89

XP_054233621.1

EC 3.4.21.89

XP_054233622.1

EC 3.4.21.89

XP_054233623.1

EC 3.4.21.89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271918.2 → NP_001258847.1 signal peptidase complex catalytic subunit SEC11A isoform 5

See identical proteins and their annotated locations for NP_001258847.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate exon in the 5' coding region which results in initiation at a downstream start site and an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (5) is longer than isoform 1.

Source sequence(s)

AK300693, BM985046, BP370483

Consensus CDS

CCDS61742.1

UniProtKB/Swiss-Prot

P0C7V7

Related

ENSP00000413121.3, ENST00000455959.7

Conserved Domains (1) summary

cl10465
Location:12 → 124

Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
NM_001271919.2 → NP_001258848.1 signal peptidase complex catalytic subunit SEC11A isoform 6

See identical proteins and their annotated locations for NP_001258848.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses an alternate in-frame exon and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (6) is longer than isoform 1.

Source sequence(s)

AI051931, CD356160, CF455691

UniProtKB/TrEMBL

H0YNA5

Related

ENSP00000453930.1, ENST00000558217.5

Conserved Domains (1) summary

cl10465
Location:38 → 103

Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
NM_001271920.2 → NP_001258849.1 signal peptidase complex catalytic subunit SEC11A isoform 4

See identical proteins and their annotated locations for NP_001258849.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses two alternate exons in the central coding region which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (4) is longer and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

BF920344, BG703137, BI545042, BM985046, BP370483

Consensus CDS

CCDS61744.1

UniProtKB/TrEMBL

H0YNG3

Related

ENSP00000452684.1, ENST00000560266.5

Conserved Domains (1) summary

cl10465
Location:38 → 122

Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
NM_001271921.2 → NP_001258850.1 signal peptidase complex catalytic subunit SEC11A isoform 1

See identical proteins and their annotated locations for NP_001258850.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1).

Source sequence(s)

AA151795, AF061737, BM763471, HY170714

Consensus CDS

CCDS73776.1

UniProtKB/TrEMBL

H0YKT4

Related

ENSP00000452932.1, ENST00000559729.5
NM_001271922.2 → NP_001258851.1 signal peptidase complex catalytic subunit SEC11A isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame exon and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC000359, BM763471, BM904189

Consensus CDS

CCDS61743.1

UniProtKB/Swiss-Prot

P67812

Related

ENSP00000452697.1, ENST00000558134.5

Conserved Domains (1) summary

cl10465
Location:38 → 122

Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
NM_014300.4 → NP_055115.1 signal peptidase complex catalytic subunit SEC11A isoform 2

See identical proteins and their annotated locations for NP_055115.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame exon in the central coding region, compared to variant 1. It encodes a longer protein (isoform 2) compared to isoform 1.

Source sequence(s)

BC014508, DC360846

Consensus CDS

CCDS45340.1

UniProtKB/Swiss-Prot

B2RAD7, B4DUL4, H0YK72, H0YK83, O75957, P21378, P67812, Q53FQ8

UniProtKB/TrEMBL

Q6IAM7

Related

ENSP00000268220.7, ENST00000268220.12

Conserved Domains (1) summary

cl10465
Location:38 → 150

Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

RNA

NR_073518.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AA151795, AF061737, BM763471, CT001736