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    Lzts3 leucine zipper, putative tumor suppressor family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 241638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lzts3provided by MGI
    Official Full Name
    leucine zipper, putative tumor suppressor family member 3provided by MGI
    Primary source
    MGI:MGI:2656976
    See related
    Ensembl:ENSMUSG00000037703 AllianceGenome:MGI:2656976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prosapip1
    Summary
    Predicted to enable PDZ domain binding activity. Predicted to be involved in protein homooligomerization; regulation of dendritic spine morphogenesis; and regulation of postsynapse assembly. Predicted to be located in postsynaptic density. Predicted to be active in dendritic spine and glutamatergic synapse. Is expressed in several structures, including central nervous system; face; limb; metanephros; and sensory organ. Orthologous to human LZTS3 (leucine zipper tumor suppressor family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 53.5), cortex adult (RPKM 37.3) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lzts3 in Genome Data Viewer
    Location:
    2 F1; 2 63.24 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130474685..130484764, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130632765..130642866, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene arginine vasopressin Neighboring gene U box domain containing 5 Neighboring gene FAST kinase domains 5 Neighboring gene STARR-positive B cell enhancer ABC_E5982 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130461487-130461688 Neighboring gene DDRGK domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10144 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward. Laguesse S, et al. Neuron, 2017 Sep 27. PMID 28890345, Free PMC Article
    2. The leucine zipper putative tumor suppressor 2 protein LZTS2 regulates kidney development. Peng Y, et al. J Biol Chem, 2011 Nov 18. PMID 21949185, Free PMC Article
    3. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
    4. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article
    5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that Prosapip1 in the NAc is a molecular transducer of structural and synaptic alterations that drive and/or maintain excessive alcohol use.
      Title: Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    leucine zipper putative tumor suppressor 3
    Names
    proSAP-interacting protein 1
    proline rich synapse associated protein interacting protein 1 (Prosapip1)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291027.1 → NP_001277956.1  leucine zipper putative tumor suppressor 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK148251, AK161711, BY258870, BY630564, BY636255, CO043440
      UniProtKB/Swiss-Prot
      A2AHG0
      Conserved Domains (1) summary
      pfam06818
      Location:448 → 643
      Fez1; Fez1

    2. NM_001291028.1 → NP_001277957.1  leucine zipper putative tumor suppressor 3 isoform c

      See identical proteins and their annotated locations for NP_001277957.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AK148251, AK161711, BY258870, BY630564, BY636255, CO043440, DN175861
      Consensus CDS
      CCDS71145.1
      UniProtKB/Swiss-Prot
      A2AHG0
      Conserved Domains (2) summary
      COG1196
      Location:231 → 426
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:351 → 550
      Fez1

    3. NM_197945.4 → NP_922936.3  leucine zipper putative tumor suppressor 3 isoform a

      See identical proteins and their annotated locations for NP_922936.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK148251, AK161711, BY258870, BY630564, BY636255, CO043440
      Consensus CDS
      CCDS50714.1
      UniProtKB/Swiss-Prot
      A2AHF9, A2AHG0, Q3TSY0, Q6PE51
      Related
      ENSMUSP00000037109.7, ENSMUST00000045761.7
      Conserved Domains (2) summary
      COG1196
      Location:346 → 539
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:465 → 664
      Fez1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130474685..130484764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251156.2 → XP_030107016.1  leucine zipper putative tumor suppressor 3 isoform X3

      Related
      ENSMUSP00000105889.2, ENSMUST00000110260.8
      Conserved Domains (2) summary
      COG1196
      Location:231 → 426
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:351 → 550
      Fez1

    2. XM_017318204.3 → XP_017173693.1  leucine zipper putative tumor suppressor 3 isoform X1

      UniProtKB/Swiss-Prot
      A2AHF9, A2AHG0, Q3TSY0, Q6PE51
      Related
      ENSMUSP00000086990.4, ENSMUST00000089561.10
      Conserved Domains (2) summary
      COG1196
      Location:346 → 539
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:465 → 664
      Fez1

    3. XM_030251155.2 → XP_030107015.1  leucine zipper putative tumor suppressor 3 isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:328 → 521
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:447 → 646
      Fez1

    4. XM_036161971.1 → XP_036017864.1  leucine zipper putative tumor suppressor 3 isoform X4

      Conserved Domains (2) summary
      TIGR02169
      Location:234 → 398
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam06818
      Location:334 → 530
      Fez1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AHG0.1 GenPept UniProtKB/Swiss-Prot:A2AHG0

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