SERP1 stress associated endoplasmic reticulum protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SERP1provided by HGNC
Official Full Name: stress associated endoplasmic reticulum protein 1provided by HGNC
Primary source: HGNC:HGNC:10759
See related: Ensembl:ENSG00000120742 MIM:617674; AllianceGenome:HGNC:10759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RAMP4
Summary: Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to act upstream of or within several processes, including positive regulation of organ growth; positive regulation of peptide hormone secretion; and positive regulation of translation. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thyroid (RPKM 68.2), prostate (RPKM 46.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q25.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (150541998..150546496, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (153293254..153297751, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (150259785..150264283, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircWDR33 alleviates human pulmonary microvascular endothelial cell injury in sepsis-associated acute lung injury by targeting miR-217-5p/SERP1 axis.
Title: CircWDR33 alleviates human pulmonary microvascular endothelial cell injury in sepsis-associated acute lung injury by targeting miR-217-5p/SERP1 axis.
Low expression of endoplasmic reticulum stress-related gene SERP1 is associated with poor prognosis and immune infiltration in skin cutaneous melanoma.
Title: Low expression of endoplasmic reticulum stress-related gene SERP1 is associated with poor prognosis and immune infiltration in skin cutaneous melanoma.
Let-7b-5p is involved in the response of endoplasmic reticulum stress in acute pulmonary embolism through upregulating the expression of stress-associated endoplasmic reticulum protein 1.
Title: Let-7b-5p is involved in the response of endoplasmic reticulum stress in acute pulmonary embolism through upregulating the expression of stress-associated endoplasmic reticulum protein 1.
SERP1 is an assembly regulator of gamma-secretase in metabolic stress conditions.
Title: SERP1 is an assembly regulator of γ-secretase in metabolic stress conditions.
This study reveals the important role of SERP1/Ysy6 and Atg8 in endoplasmic reticulum stress response and virulence in Candida albicans.
Title: Stress-associated endoplasmic reticulum protein 1 (SERP1) and Atg8 synergistically regulate unfolded protein response (UPR) that is independent on autophagy in Candida albicans.
Study demonstrated that SERP1 expression level was significantly upregulated in human pancreatic ductal adenocarcinoma (PDAC) tissues which positively associated with advanced clinical stage and shorter survival time (OS and DFS). Downregulated SERP1 expression promoted PDAC cell apoptosis and inhibited NF-kappaB activation probably by upregulating SRPRB expression.
Title: SERP1 is a novel marker of poor prognosis in pancreatic ductal adenocarcinoma patients via anti-apoptosis and regulating SRPRB/NF-κB axis.
expression of SFRP1 mRNA and protein correlates with the Gleason score, survival rate and response for endocrine therapy of prostate cancer.
Title: Diagnostic value of SFRP1 as a favorable predictive and prognostic biomarker in patients with prostate cancer.
SFRP1 DNA methylation, accumulates with age in normal-appearing kidney tissues and is associated with increased renal cancer risk.
Title: SFRP1 CpG island methylation locus is associated with renal cell cancer susceptibility and disease recurrence.
SERP1 is a novel cochaperone and regulator of ENaC expression.
Title: Regulation of ENaC biogenesis by the stress response protein SERP1.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat modulates SERP1 expression in neuron cells	PubMed
Vpr	vpr	The RNA and protein levels of stress-associated endoplasmic reticulum protein 1 (SERP1) decreases in Vpr-treated human neurons compared to the untreated control	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH48541 (e-PCR)
- UniSTS:54788

D3S2808E (e-PCR)
- UniSTS:150844

SHGC-56912 (e-PCR)
- UniSTS:22864

RH15894 (e-PCR)
- UniSTS:32593

D3S2837E (e-PCR)
- UniSTS:35414

G19910 (e-PCR)
- UniSTS:74436

A002B48 (e-PCR)
- UniSTS:74437

NoName (e-PCR)
- UniSTS:486603

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in muscle organ morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane organization	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of growth hormone secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of organ growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in post-embryonic development	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	TAS Traceable Author Statement more info	PubMed
involved_in protein modification process	TAS Traceable Author Statement more info	PubMed
involved_in skeletal system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
located_in ribosome	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: stress-associated endoplasmic reticulum protein 1

Names: ribosome associated membrane protein 4; ribosome-attached membrane protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.