Mvb12b multivesicular body subunit 12B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mvb12bprovided by MGI
Official Full Name: multivesicular body subunit 12Bprovided by MGI
Primary source: MGI:MGI:1919793
See related: Ensembl:ENSMUSG00000038740 AllianceGenome:MGI:1919793
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam125b; 2610200O14Rik; 2610528K11Rik
Summary: Predicted to enable lipid binding activity. Predicted to be involved in regulation of epidermal growth factor receptor signaling pathway; viral budding; and virus maturation. Predicted to be located in several cellular components, including cytosol; early endosome; and nucleus. Predicted to be part of ESCRT I complex. Predicted to be active in late endosome. Is expressed in 2nd branchial arch; 3rd branchial pouch; cerebral cortex intermediate zone; and cortical plate. Orthologous to human MVB12B (multivesicular body subunit 12B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 7.7), CNS E14 (RPKM 6.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.51 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (33619965..33777958, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (33729953..33887946, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multivesicular body protein MVB12b is a target for TANK-binding kinase 1 phosphorylation, which is essential for the sorting of DNA into extracellular vesicles and stimulation of bystander cells.
Title: Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

30.MMHAP97FRB12.seq (e-PCR)
- UniSTS:123925

NoName (e-PCR)
- UniSTS:234367

D11S3575 (e-PCR)
- UniSTS:152814

Fam125b (e-PCR), detects polymorphism
- UniSTS:526075

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in viral budding	IBA Inferred from Biological aspect of Ancestor more info
involved_in viral budding	IEA Inferred from Electronic Annotation more info
involved_in viral budding	ISO Inferred from Sequence Orthology more info
involved_in virus maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in virus maturation	IEA Inferred from Electronic Annotation more info
involved_in virus maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of ESCRT I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESCRT I complex	IEA Inferred from Electronic Annotation more info
part_of ESCRT I complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: multivesicular body subunit 12B

Names: ESCRT-I complex subunit MVB12B; family with sequence similarity 125, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175184.4 → NP_780393.2 multivesicular body subunit 12B

See identical proteins and their annotated locations for NP_780393.2

Status: VALIDATED

Source sequence(s)

AL845360, BX649361

Consensus CDS

CCDS15946.1

UniProtKB/Swiss-Prot

A2ARF1, Q6KAU4, Q6PB42

Related

ENSMUSP00000048901.4, ENSMUST00000041555.10

Conserved Domains (1) summary

pfam10240
Location:46 → 297

DUF2464; Protein of unknown function (DUF2464)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

33619965..33777958 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498373.1 → XP_006498436.1 multivesicular body subunit 12B isoform X11

Conserved Domains (1) summary

pfam10240
Location:47 → 222

DUF2464; Multivesicular body subunit 12
XM_006498370.1 → XP_006498433.1 multivesicular body subunit 12B isoform X5

Conserved Domains (1) summary

pfam10240
Location:47 → 250

DUF2464; Multivesicular body subunit 12
XM_036162602.1 → XP_036018495.1 multivesicular body subunit 12B isoform X7

UniProtKB/TrEMBL

Q8C2W4

Conserved Domains (1) summary

pfam10240
Location:17 → 268

DUF2464; Multivesicular body subunit 12
XM_036162603.1 → XP_036018496.1 multivesicular body subunit 12B isoform X7

UniProtKB/TrEMBL

Q8C2W4

Conserved Domains (1) summary

pfam10240
Location:17 → 268

DUF2464; Multivesicular body subunit 12
XM_030252115.2 → XP_030107975.1 multivesicular body subunit 12B isoform X7

UniProtKB/TrEMBL

Q8C2W4

Conserved Domains (1) summary

pfam10240
Location:17 → 268

DUF2464; Multivesicular body subunit 12
XM_011239194.2 → XP_011237496.1 multivesicular body subunit 12B isoform X10

Conserved Domains (1) summary

pfam10240
Location:47 → 251

DUF2464; Multivesicular body subunit 12
XM_006498367.5 → XP_006498430.1 multivesicular body subunit 12B isoform X1

Conserved Domains (1) summary

pfam10240
Location:47 → 250

DUF2464; Multivesicular body subunit 12
XM_030252114.2 → XP_030107974.1 multivesicular body subunit 12B isoform X3

Conserved Domains (1) summary

pfam10240
Location:18 → 221

DUF2464; Multivesicular body subunit 12
XM_030252112.2 → XP_030107972.1 multivesicular body subunit 12B isoform X3

Conserved Domains (1) summary

pfam10240
Location:18 → 221

DUF2464; Multivesicular body subunit 12
XM_030252113.2 → XP_030107973.1 multivesicular body subunit 12B isoform X3

Conserved Domains (1) summary

pfam10240
Location:18 → 221

DUF2464; Multivesicular body subunit 12
XM_006498368.5 → XP_006498431.1 multivesicular body subunit 12B isoform X2

Conserved Domains (1) summary

pfam10240
Location:39 → 242

DUF2464; Multivesicular body subunit 12
XM_006498372.1 → XP_006498435.1 multivesicular body subunit 12B isoform X9

Conserved Domains (1) summary

pfam10240
Location:47 → 251

DUF2464; Multivesicular body subunit 12
XM_006498371.5 → XP_006498434.1 multivesicular body subunit 12B isoform X6

Conserved Domains (1) summary

pfam10240
Location:18 → 222

DUF2464; Multivesicular body subunit 12
XM_006498369.4 → XP_006498432.1 multivesicular body subunit 12B isoform X4

Conserved Domains (1) summary

pfam10240
Location:47 → 251

DUF2464; Multivesicular body subunit 12
XM_036162605.1 → XP_036018498.1 multivesicular body subunit 12B isoform X8

Conserved Domains (1) summary

pfam10240
Location:46 → 251

DUF2464; Multivesicular body subunit 12