Lama5 laminin, alpha 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lama5provided by MGI
Official Full Name: laminin, alpha 5provided by MGI
Primary source: MGI:MGI:105382
See related: Ensembl:ENSMUSG00000015647 AllianceGenome:MGI:105382
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: [a]5; mKIAA0533; laminin-511
Summary: Enables integrin binding activity. Involved in postsynapse organization. Acts upstream of or within several processes, including hair follicle development; morphogenesis of an epithelium; and trunk neural crest cell migration. Located in extracellular matrix. Part of laminin-10 complex. Is active in several cellular components, including collagen-containing extracellular matrix; glutamatergic synapse; and synaptic cleft. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; salivary gland primordium; and sensory organ. Used to study cystic kidney disease. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human LAMA5 (laminin subunit alpha 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 40.7), mammary gland adult (RPKM 30.3) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 102.7 cM

Exon count:: 79

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (179818166..179867652, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (180176373..180225904, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A dispensable role of mural cell-derived laminin-alpha5 in intracerebral hemorrhage.
Title: A dispensable role of mural cell-derived laminin-α5 in intracerebral hemorrhage.
LAMA5: A new pathogenic gene for non-syndromic cleft lip with or without cleft palate.
Title: LAMA5: A new pathogenic gene for non-syndromic cleft lip with or without cleft palate.
Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis.
Title: Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell Transdifferentiation and Pancreatic Cancer Initiation Via LAMA5/ITGA4 Axis.
A dispensable role of oligodendrocyte-derived laminin-alpha5 in brain homeostasis and intracerebral hemorrhage.
Title: A dispensable role of oligodendrocyte-derived laminin-α5 in brain homeostasis and intracerebral hemorrhage.
Endothelial and mural laminin-alpha5 contributes to neurovascular integrity maintenance.
Title: Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance.
A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects.
Title: A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects.
Laminin-511 and recombinant vitronectin supplementation enables human pluripotent stem cell culture and differentiation on conventional tissue culture polystyrene surfaces in xeno-free conditions.
Title: Laminin-511 and recombinant vitronectin supplementation enables human pluripotent stem cell culture and differentiation on conventional tissue culture polystyrene surfaces in xeno-free conditions.
Canonical Wnt signaling regulates branching morphogenesis of submandibular gland by modulating levels of lama5.
Title: Canonical Wnt signaling regulates branching morphogenesis of submandibular gland by modulating levels of lama5.
Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin alpha5.
Title: Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin α5.
Regulation and Function of Laminin A5 during Mouse and Human Decidualization.
Title: Regulation and Function of Laminin A5 during Mouse and Human Decidualization.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (3) 1 citation
Gene trapped (1) 1 citation
Targeted (10) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125816 (e-PCR)
- UniSTS:162562

D2Wsu85e (e-PCR), detects polymorphism
- UniSTS:142379

RH124758 (e-PCR)
- UniSTS:161580

AI853660 (e-PCR)
- UniSTS:178792

Lama5 (e-PCR), detects polymorphism
- UniSTS:143749

Lama5 (e-PCR), detects polymorphism
- UniSTS:143750

RH124685 (e-PCR)
- UniSTS:161507

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within morphogenesis of a polarized epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of embryonic development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal system morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within trunk neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix of synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix of synaptic cleft	IEP Inferred from Expression Pattern more info	PubMed
is_active_in extracellular matrix of synaptic cleft	IMP Inferred from Mutant Phenotype more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of laminin-10 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of laminin-10 complex	ISO Inferred from Sequence Orthology more info
part_of laminin-5 complex	IEA Inferred from Electronic Annotation more info
part_of laminin-5 complex	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: laminin subunit alpha-5

Names: laminin-10 subunit alpha; laminin-11 subunit alpha; laminin-15 subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081171.2 → NP_001074640.1 laminin subunit alpha-5 precursor

See identical proteins and their annotated locations for NP_001074640.1

Status: VALIDATED

Source sequence(s)

AI853660, AJ293593, AK158204, AL663027, CJ124774, CK021961, CN702366, DV646114

Consensus CDS

CCDS38375.1

UniProtKB/Swiss-Prot

A2ABW7, Q61001, Q9JHQ6

Related

ENSMUSP00000015791.6, ENSMUST00000015791.6

Conserved Domains (10) summary

smart00180
Location:2025 → 2069

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:1690 → 1819

LamB; Laminin B domain

smart00282
Location:3542 → 3669

LamG; Laminin G domain

cd00055
Location:682 → 724

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3337 → 3495

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00053
Location:1443 → 1491

Laminin_EGF; Laminin EGF domain

pfam00055
Location:59 → 303

Laminin_N; Laminin N-terminal (Domain VI)

pfam06008
Location:2190 → 2452

Laminin_I; Laminin Domain I

pfam06009
Location:2642 → 2764

Laminin_II; Laminin Domain II

cl02193
Location:2230 → 2316

VirB5_like; VirB5 protein family