Nod1 nucleotide-binding oligomerization domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nod1provided by MGI
Official Full Name: nucleotide-binding oligomerization domain containing 1provided by MGI
Primary source: MGI:MGI:1341839
See related: Ensembl:ENSMUSG00000038058 AllianceGenome:MGI:1341839
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Card4; Nlrc1; mNod1; C230079P11; F830007N14Rik
Summary: Enables pattern recognition receptor activity and peptidoglycan binding activity. Involved in several processes, including nucleotide-binding activity oligomerization domain containing 1 signaling pathway; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of dendritic cell antigen processing and presentation. Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of cytokine production; and positive regulation of xenophagy. Located in phagocytic vesicle. Is expressed in several structures, including alimentary system; autopod; brain; olfactory epithelium; and urinary system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 28.6), spleen adult (RPKM 22.7) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.22 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (54900927..54949655, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (54923942..54972674, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NOD1 deficiency ameliorates the progression of diabetic retinopathy by modulating bone marrow-retina crosstalk.
Title: NOD1 deficiency ameliorates the progression of diabetic retinopathy by modulating bone marrow-retina crosstalk.
Microbial ligand-independent regulation of lymphopoiesis by NOD1.
Title: Microbial ligand-independent regulation of lymphopoiesis by NOD1.
NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice.
Title: NOD1 mediates interleukin-18 processing in epithelial cells responding to Helicobacter pylori infection in mice.
NOD1 mediated D. pteronyssinus-induced allergic airway inflammation through RIP2/NF-kappaB.
Title: NOD1 mediated D. pteronyssinus-induced allergic airway inflammation through RIP2/NF-κB.
High-fat diet activates splenic NOD1 and enhances neutrophil recruitment and neutrophil extracellular traps release in the spleen of ApoE-deficient mice.
Title: High-fat diet activates splenic NOD1 and enhances neutrophil recruitment and neutrophil extracellular traps release in the spleen of ApoE-deficient mice.
CTRP-3 Regulates NOD1-mediated Inflammation and NOD1 Expression in Adipocytes and Adipose Tissue.
Title: CTRP-3 Regulates NOD1-mediated Inflammation and NOD1 Expression in Adipocytes and Adipose Tissue.
Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells.
Title: Nod1 promotes colorectal carcinogenesis by regulating the immunosuppressive functions of tumor-infiltrating myeloid cells.
Nucleotide-Oligomerizing Domain-1 Activation Exaggerates Cigarette Smoke-Induced Chronic Obstructive Pulmonary-Like Disease in Mice.
Title: Nucleotide-Oligomerizing Domain-1 Activation Exaggerates Cigarette Smoke-Induced Chronic Obstructive Pulmonary-Like Disease in Mice.
NOD1 sensing of house dust mite-derived microbiota promotes allergic experimental asthma.
Title: NOD1 sensing of house dust mite-derived microbiota promotes allergic experimental asthma.
Innate Immune Nod1/RIP2 Signaling Is Essential for Cardiac Hypertrophy but Requires Mitochondrial Antiviral Signaling Protein for Signal Transductions and Energy Balance.
Title: Innate Immune Nod1/RIP2 Signaling Is Essential for Cardiac Hypertrophy but Requires Mitochondrial Antiviral Signaling Protein for Signal Transductions and Energy Balance.

Submit: New GeneRIF Correction See all GeneRIFs (112)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CARD domain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to muramyl dipeptide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to muramyl dipeptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-negative bacterium	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of bacterium	ISO Inferred from Sequence Orthology more info
involved_in detection of bacterium	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of macrophage cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendritic cell antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of xenophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of xenophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nucleotide-binding oligomerization domain-containing protein 1

Names: caspase recruitment domain 4; caspase recruitment domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171007.1 → NP_001164478.1 nucleotide-binding oligomerization domain-containing protein 1

See identical proteins and their annotated locations for NP_001164478.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC079183, AI645572, AK137585, AY160222

Consensus CDS

CCDS20160.1

UniProtKB/Swiss-Prot

Q8BHB0, Q8BUT6

UniProtKB/TrEMBL

Q540J8

Related

ENSMUSP00000130487.2, ENSMUST00000168172.4

Conserved Domains (6) summary

sd00033
Location:730 → 757

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain

pfam17776
Location:517 → 665

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:460 → 515

NOD2_WH; NOD2 winged helix domain

cl14633
Location:21 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl39015
Location:728 → 941

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_172729.3 → NP_766317.1 nucleotide-binding oligomerization domain-containing protein 1

See identical proteins and their annotated locations for NP_766317.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AI645572, AK137585, AY160222

Consensus CDS

CCDS20160.1

UniProtKB/Swiss-Prot

Q8BHB0, Q8BUT6

UniProtKB/TrEMBL

Q540J8

Related

ENSMUSP00000055747.9, ENSMUST00000060655.15

Conserved Domains (6) summary

sd00033
Location:730 → 757

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain

pfam17776
Location:517 → 665

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:460 → 515

NOD2_WH; NOD2 winged helix domain

cl14633
Location:21 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl39015
Location:728 → 941

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

54900927..54949655 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505278.5 → XP_006505341.1 nucleotide-binding oligomerization domain-containing protein 1 isoform X1

Conserved Domains (6) summary

sd00033
Location:730 → 754

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:197 → 367

NACHT; NACHT domain

pfam17776
Location:517 → 667

NLRC4_HD2; NLRC4 helical domain HD2

pfam17779
Location:460 → 515

NOD2_WH; NOD2 winged helix domain

cl14633
Location:21 → 104

DD; Death Domain Superfamily of protein-protein interaction domains

cl39015
Location:728 → 913

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...