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    Klk9 kallikrein related-peptidase 9 [ Mus musculus (house mouse) ]

    Gene ID: 101533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klk9provided by MGI
    Official Full Name
    kallikrein related-peptidase 9provided by MGI
    Primary source
    MGI:MGI:1921082
    See related
    Ensembl:ENSMUSG00000047884 AllianceGenome:MGI:1921082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200016C12Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be active in extracellular space and secretory granule. Orthologous to human KLK9 (kallikrein related peptidase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in stomach adult (RPKM 11.6) and lung adult (RPKM 2.5) See more
    Orthologs
    human all
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    Genomic context

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    See Klk9 in Genome Data Viewer
    Location:
    7 B3; 7 28.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43441048..43446182)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43791625..43796758)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein related-peptidase 11 Neighboring gene kallikrein related-peptidase 10 Neighboring gene kallikrein related-peptidase 8 Neighboring gene kallikrein related-peptidase 7 (chymotryptic, stratum corneum)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains. Murakami K, et al. Protein Pept Lett, 2014. PMID 25666037
    2. Human tissue kallikreins: physiologic roles and applications in cancer. Borgoño CA, et al. Mol Cancer Res, 2004 May. PMID 15192120
    3. Organization and evolution of the glandular kallikrein locus in Mus musculus. Olsson AY, et al. Biochem Biophys Res Commun, 2002 Nov 29. PMID 12437987
    4. Taxon-specific evolution of glandular kallikrein genes and identification of a progenitor of prostate-specific antigen. Olsson AY, et al. Genomics, 2004 Jul. PMID 15203212
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130095, MGC130096

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kallikrein-9
    Names
    kallikrein 9
    kallikrein-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028660.3 → NP_082936.2  kallikrein-9 precursor

      See identical proteins and their annotated locations for NP_082936.2

      Status: VALIDATED

      Source sequence(s)
      AI414707, AI536290, BC109326, BX520246
      Consensus CDS
      CCDS39937.1
      UniProtKB/TrEMBL
      A0A0B6VSQ8, Q32M27
      Related
      ENSMUSP00000005891.6, ENSMUST00000005891.7
      Conserved Domains (1) summary
      cd00190
      Location:24 → 247
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43441048..43446182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540537.4 → XP_006540600.1  kallikrein-9 isoform X1

      See identical proteins and their annotated locations for XP_006540600.1

      UniProtKB/TrEMBL
      A0A0B6VSQ8, Q32M27
      Conserved Domains (1) summary
      cd00190
      Location:24 → 247
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. XM_030241942.2 → XP_030097802.1  kallikrein-9 isoform X2

      Conserved Domains (1) summary
      smart00020
      Location:16 → 156
      Tryp_SPc; Trypsin-like serine protease
    Nucleotide Protein Strain
    Heading Accession and Version

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