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    Asb7 ankyrin repeat and SOCS box-containing 7 [ Mus musculus (house mouse) ]

    Gene ID: 117589, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Asb7provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 7provided by MGI
    Primary source
    MGI:MGI:2152835
    See related
    Ensembl:ENSMUSG00000030509 AllianceGenome:MGI:2152835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asb-7; D030055C23Rik
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB7 (ankyrin repeat and SOCS box containing 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 1.5), whole brain E14.5 (RPKM 1.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asb7 in Genome Data Viewer
    Location:
    7 C; 7 36.03 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (66294220..66339601, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (66644565..66689879, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19085 Neighboring gene STARR-seq mESC enhancer starr_19088 Neighboring gene predicted gene, 53392 Neighboring gene predicted gene, 33570 Neighboring gene STARR-seq mESC enhancer starr_19090 Neighboring gene STARR-positive B cell enhancer ABC_E11356 Neighboring gene STARR-positive B cell enhancer ABC_E1735 Neighboring gene lines homolog 1 Neighboring gene STARR-seq mESC enhancer starr_19091 Neighboring gene ceramide synthase 3 Neighboring gene predicted gene, 33627 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ASB7 Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation. Liu Y, et al. Front Cell Dev Biol, 2020. PMID 33251222, Free PMC Article
    2. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 7
    Names
    ankyrin repeat and SOCS box-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080443.2 → NP_536691.2  ankyrin repeat and SOCS box protein 7

      See identical proteins and their annotated locations for NP_536691.2

      Status: VALIDATED

      Source sequence(s)
      AC115761, AC120791
      Consensus CDS
      CCDS21346.1
      UniProtKB/Swiss-Prot
      G3UVX4, Q91ZU0
      Related
      ENSMUSP00000122395.2, ENSMUST00000124899.8
      Conserved Domains (4) summary
      PTZ00322
      Location:219 → 272
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:21 → 241
      PHA02875; ankyrin repeat protein; Provisional
      cd03726
      Location:273 → 317
      SOCS_ASB7; SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      sd00045
      Location:81 → 114
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_003961.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC115761, AC120791
      Related
      ENSMUST00000131320.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      66294220..66339601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540568.5 → XP_006540631.1  ankyrin repeat and SOCS box protein 7 isoform X2

      See identical proteins and their annotated locations for XP_006540631.1

      UniProtKB/TrEMBL
      C0H5Y0
      Conserved Domains (4) summary
      PHA02876
      Location:4 → 200
      PHA02876; ankyrin repeat protein; Provisional
      cd03726
      Location:214 → 258
      SOCS_ASB7; SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      sd00045
      Location:22 → 55
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:26 → 121
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006540567.5 → XP_006540630.1  ankyrin repeat and SOCS box protein 7 isoform X1

      See identical proteins and their annotated locations for XP_006540630.1

      UniProtKB/Swiss-Prot
      G3UVX4, Q91ZU0
      Conserved Domains (4) summary
      PTZ00322
      Location:219 → 272
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      PHA02875
      Location:21 → 241
      PHA02875; ankyrin repeat protein; Provisional
      cd03726
      Location:273 → 317
      SOCS_ASB7; SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
      sd00045
      Location:81 → 114
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_004933996.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178236.3: Suppressed sequence

      Description
      NM_178236.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZU0.2 GenPept UniProtKB/Swiss-Prot:Q91ZU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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