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    Zfp90 zinc finger protein 90 [ Mus musculus (house mouse) ]

    Gene ID: 22751, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp90provided by MGI
    Official Full Name
    zinc finger protein 90provided by MGI
    Primary source
    MGI:MGI:104786
    See related
    Ensembl:ENSMUSG00000031907 AllianceGenome:MGI:104786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NK10; Zfp64; Zfp83; KRAB17; mKIAA1954; 6430515L01Rik
    Summary
    Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; hemolymphoid system gland; lung; male reproductive system; and urinary system. Orthologous to human ZFP90 (ZFP90 zinc finger protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 6.3), CNS E14 (RPKM 6.0) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp90 in Genome Data Viewer
    Location:
    8 D3; 8 53.14 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107141929..107153575)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106415295..106426943)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39238 Neighboring gene STARR-positive B cell enhancer mm9_chr8:108935799-108936099 Neighboring gene predicted gene, 34026 Neighboring gene STARR-positive B cell enhancer ABC_E3802 Neighboring gene STARR-seq mESC enhancer starr_22555 Neighboring gene predicted gene, 51545 Neighboring gene STARR-seq mESC enhancer starr_22556 Neighboring gene STARR-seq mESC enhancer starr_22558 Neighboring gene STARR-seq mESC enhancer starr_22559 Neighboring gene cadherin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells. Liu T, et al. Cell Death Dis, 2018 Jun 7. PMID 29880802, Free PMC Article
    2. A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90. Yu CY, et al. Oncogene, 2020 Feb. PMID 31641208, Free PMC Article
    3. Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. Hata L, et al. J Mol Cell Cardiol, 2011 Jun. PMID 21284946
    4. Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains. Lange R, et al. DNA Cell Biol, 1995 Nov. PMID 7576184
    5. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zfp90 was highly expressed in hematopoietic stem cells.
      Title: The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells.
    2. Zfp90 functions as a negative regulator of NRSF and contributes to genetic remodeling during the development of cardiac dysfunction.
      Title: Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 90
    Names
    Nk10 expressed protein
    zfp-90
    zinc finger protein 83
    zinc finger protein 90 homolog
    zinc finger protein NK10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368328.1 → NP_001355257.1  zinc finger protein 90 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC134615, AC164096

    2. NM_001368329.1 → NP_001355258.1  zinc finger protein 90 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134615, AC164096
      Conserved Domains (2) summary
      COG5048
      Location:189 → 617
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:516 → 536
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001368330.1 → NP_001355259.1  zinc finger protein 90 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC134615, AC164096

    4. NM_001368331.1 → NP_001355260.1  zinc finger protein 90 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC134615, AC164096

    5. NM_011764.4 → NP_035894.1  zinc finger protein 90 isoform 2

      See identical proteins and their annotated locations for NP_035894.1

      Status: VALIDATED

      Source sequence(s)
      AC134615, AC164096
      Consensus CDS
      CCDS22635.1
      UniProtKB/Swiss-Prot
      Q3U4J5, Q543I6, Q61967
      Related
      ENSMUSP00000034382.8, ENSMUST00000034382.8
      Conserved Domains (5) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:197 → 625
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:524 → 544
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:536 → 561
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      107141929..107153575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530849.5 → XP_006530912.1  zinc finger protein 90 isoform X1

      See identical proteins and their annotated locations for XP_006530912.1

      Related
      ENSMUST00000211958.2
      Conserved Domains (2) summary
      COG5048
      Location:189 → 617
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:516 → 536
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61967.1 GenPept UniProtKB/Swiss-Prot:Q61967

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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