Mre11a MRE11A homolog A, double strand break repair nuclease [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mre11aprovided by MGI
Official Full Name: MRE11A homolog A, double strand break repair nucleaseprovided by MGI
Primary source: MGI:MGI:1100512
See related: Ensembl:ENSMUSG00000031928 AllianceGenome:MGI:1100512
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mre11; Mre11b
Summary: Enables nuclease activity. Involved in DNA strand resection involved in replication fork processing; chromosome organization; and double-strand break repair via homologous recombination. Acts upstream of or within several processes, including double-strand break repair; homologous chromosome pairing at meiosis; and mitotic DNA damage checkpoint signaling. Located in PML body. Part of Mre11 complex. Colocalizes with chromosome, telomeric region. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 5.2), liver E14 (RPKM 3.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A2; 9 4.33 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (14695971..14748421)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (14784654..14837125)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRE11 is essential for the long-term viability of undifferentiated spermatogonia.
Title: MRE11 is essential for the long-term viability of undifferentiated spermatogonia.
Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder.
Title: Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder.
A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation.
Title: A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation.
The DNA Damage Sensor MRE11 Regulates Efficient Replication of the Autonomous Parvovirus Minute Virus of Mice.
Title: The DNA Damage Sensor MRE11 Regulates Efficient Replication of the Autonomous Parvovirus Minute Virus of Mice.
RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.
Title: RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.
We propose that XLF and H2AX function in series to prevent replication stress induced by the MRE11-dependent resection of regressed arms at reversed replication forks.
Title: XLF and H2AX function in series to promote replication fork stability.
Nbn-Mre11 interaction is required for tumor suppression and genomic integrity.
Title: Nbn-Mre11 interaction is required for tumor suppression and genomic integrity.
MRE11 disease-associated splice mutation leads to low protein levels and cellular mislocalization.
Title: Reversible mislocalization of a disease-associated MRE11 splice variant product.
the essential role of Nbs1 is via its interaction with Mre11 and that most of the Nbs1 protein is dispensable for Mre11 complex functions and suggest that Mre11 and Rad50 directly activate ATM.
Title: The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.
Low MRE11 expression is associated with B-cell lymphomas.
Title: MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236059

U60318 (e-PCR)
- UniSTS:163453

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3'-5'-DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5'-DNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA endodeoxyribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA endodeoxyribonuclease activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA endodeoxyribonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info	PubMed
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA double-strand break processing	ISO Inferred from Sequence Orthology more info
involved_in DNA double-strand break processing	NAS Non-traceable Author Statement more info	PubMed
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
involved_in DNA strand resection involved in replication fork processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA strand resection involved in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in DNA strand resection involved in replication fork processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA strand resection involved in replication fork processing	NAS Non-traceable Author Statement more info	PubMed
involved_in R-loop processing	ISO Inferred from Sequence Orthology more info
involved_in R-loop processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via nonhomologous end joining	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homologous recombination	NAS Non-traceable Author Statement more info	PubMed
involved_in meiotic DNA double-strand break formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2 DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G2/M transition checkpoint	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic intra-S DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic intra-S DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomeric 3' overhang formation	IEA Inferred from Electronic Annotation more info
involved_in telomeric 3' overhang formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BRCA1-C complex	ISO Inferred from Sequence Orthology more info
part_of Mre11 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Mre11 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Mre11 complex	ISO Inferred from Sequence Orthology more info
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosomal region	NAS Non-traceable Author Statement more info	PubMed
colocalizes_with chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISS Inferred from Sequence or Structural Similarity more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: double-strand break repair protein MRE11

Names: MRE11 homolog 1; MRE11 homolog A; double-strand break repair protein MRE11A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; mmMRE11A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310728.2 → NP_001297657.1 double-strand break repair protein MRE11 isoform 2

See identical proteins and their annotated locations for NP_001297657.1

Status: VALIDATED

Source sequence(s)

AC136743, CT030247

Consensus CDS

CCDS80958.1

UniProtKB/TrEMBL

Q3UJN6

Related

ENSMUSP00000111295.4, ENSMUST00000115632.10

Conserved Domains (1) summary

cl27188
Location:10 → 375

Mre11_DNA_bind; Mre11 DNA-binding presumed domain
NM_001411891.1 → NP_001398820.1 double-strand break repair protein MRE11 isoform 1

Status: VALIDATED

Source sequence(s)

AC136743, CT030247

UniProtKB/Swiss-Prot

Q61216, Q62430

UniProtKB/TrEMBL

Q3URU4
NM_001411892.1 → NP_001398821.1 double-strand break repair protein MRE11 isoform 2

Status: VALIDATED

Source sequence(s)

AC136743, CT030247
NM_001411893.1 → NP_001398822.1 double-strand break repair protein MRE11 isoform 3

Status: VALIDATED

Source sequence(s)

AC136743, CT030247
NM_001411894.1 → NP_001398823.1 double-strand break repair protein MRE11 isoform 3

Status: VALIDATED

Source sequence(s)

AC136743, CT030247
NM_001411895.1 → NP_001398824.1 double-strand break repair protein MRE11 isoform 4

Status: VALIDATED

Source sequence(s)

AC136743, CT030247
NM_001411896.1 → NP_001398825.1 double-strand break repair protein MRE11 isoform 5

Status: VALIDATED

Source sequence(s)

AC136743, CT030247
NM_001411897.1 → NP_001398826.1 double-strand break repair protein MRE11 isoform 6

Status: VALIDATED

Source sequence(s)

AC136743, CT030247
NM_001411898.1 → NP_001398827.1 double-strand break repair protein MRE11 isoform 6

Status: VALIDATED

Source sequence(s)

AC136743, CT030247
NM_001411899.1 → NP_001398828.1 double-strand break repair protein MRE11 isoform 7

Status: VALIDATED

Source sequence(s)

AC136743, CT030247
NM_018736.4 → NP_061206.1 double-strand break repair protein MRE11 isoform 1

See identical proteins and their annotated locations for NP_061206.1

Status: VALIDATED

Source sequence(s)

AC136743, CT030247

Consensus CDS

CCDS22827.1

UniProtKB/Swiss-Prot

Q61216, Q62430

UniProtKB/TrEMBL

Q3UJN6, Q3URU4

Related

ENSMUSP00000034405.5, ENSMUST00000034405.11

Conserved Domains (1) summary

cl27188
Location:10 → 402

Mre11_DNA_bind; Mre11 DNA-binding presumed domain

RNA

NR_177972.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC136743, CT030247
NR_177973.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC136743, CT030247
NR_177974.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC136743, CT030247
NR_177975.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC136743, CT030247